奈达铂杂质 | 41349-15-9

• 物质功能分类: 有机原料 - 有机金属类化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 奈达铂杂质
• 英文名称: cis-diammineoxalatoplatinum(II)
• 英文别名: (SP-4-2)-diammineoxalatoplatinum(II)；cis-diammine(oxalato)platinum(II)；oxalatodiammineplatinum(II)；cis-diamminooxalatoplatinum(II)；cis-(Oxalatodiammine)platinum(II)；azane;oxalate;platinum(2+)
• CAS: 41349-15-9
• 化学式: C₂H₆N₂O₄Pt
• 分子量: 317.161
• InChiKey: PMYNWPKKFGOGDB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.19
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  奈达铂杂质 在 氯 作用下， 以 水 为溶剂， 生成 {Pt(a2C2O4)Cl2}
  参考文献：
  名称：

  Goremykin, V. I.; Gladyshevskaya, K. A., 1940, vol. 28, p. 625 - 628

  摘要：

  DOI：
• 作为产物：
  描述：

  potassium amminetrichloroplatinate 在 NH₄-oxalate 作用下， 以 not given 为溶剂， 生成 奈达铂杂质
  参考文献：
  名称：

  Cossa, A., Gazzetta Chimica Italiana, 1890, vol. 20, p. 725 - 753

  摘要：

  DOI：

文献信息

• [EN] MONOMALEIMIDE-FUNCTIONALIZED PLATINUM COMPOUNDS FOR CANCER THERAPY<br/>[FR] COMPOSÉS DE PLATINE À FONCTION MONOMALÉIMIDE POUR LE TRAITEMENT DU CANCER
  申请人：UNIV WIEN MED

  公开号：WO2017097986A1

  公开（公告）日：2017-06-15

  The present invention relates to novel monomaleimide-functionalized platinum compounds of formula (I), including in particular novel monomaleimide-functionalized oxaliplatin and carboplatin derivatives, as well as their use as medicaments, particularly for the treatment or prevention of cancer.

  本发明涉及一种新型单马来酰亚胺官能化铂化合物，其化学式为(I)，其中包括新型单马来酰亚胺官能化奥沙利铂和卡铂衍生物，以及它们作为药物的用途，特别是用于治疗或预防癌症。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Pt: MVol.D, 12, page 63 - 66
  作者：

  DOI：——

  日期：——
• Synthesis and characterization of Pt(II) complexes with amine and carboxylato ligands. Crystal structure of (1,1-cyclobutanedicarboxylato)di(ethylamine)platinum(II)·H2O
  作者：Fernande D Rochon、Letitia M Gruia

  DOI：10.1016/s0020-1693(00)00171-7

  日期：2000.8

  Two methods for the synthesis of compounds of the type cis-PtA(2)X(2) (A(2) = bidentate amine or two monodentate amines and X-2 = bidentate or two monodentate carboxylato ligands) were evaluated. The compounds were characterized by multinuclear NMR and IR spectroscopies. The Pt-195 NMR chemical shifts were in the range -1615 to -1976 ppm, the higher field values corresponding to the complexes containing bidentate ligands. The coupling constants (3)J(Pt-195-H-1) are approximately 35 Hz, while the (2)J(Pt-195-(HN)-H-1) are about 70 Hz. One coupling constant (2)J(Pt-195-C-13) (53 Hz) was also measured. The crystal structure of the compound, cis-Pt(1,1-cyclobutanedicarboxylato)(C2H5NH2)(2). H2O belongs to the P2(1)/n space group with a = 9.468(5), b = 9.365(4), c = 16.473(7) Angstrom, beta = 105.08(3)degrees, Z = 4 and R-1 = 0.0576. The Pt-N bond distances are 1.992(5) and 2.020(5) Angstrom, while the Pt-O bonds are 2.000(4) and 2.015(4) Angstrom. The molecules are held together by intermolecular H-bonds involving the lattice water molecules and the two free carbonyl O atoms and between the amino H atoms and the Pt-bonded C-O groups. (C) 2000 Elsevier Science S.A. All rights reserved.
• Cossa, A., 1891, vol. 41, p. 3 - 23
  作者：Cossa, A.

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Pt: MVol.D, 191, page 419 - 421
  作者：

  DOI：——

  日期：——