1,5-二碘-3-甲基戊烷 | 51174-46-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机碘化物
• 中文名称: 1,5-二碘-3-甲基戊烷
• 英文名称: 3-methyl-1,5-diiodopentane
• 英文别名: 1,5-diiodo-3-methyl-pentane；1.5-Dijod-3-methyl-pentan；1,5-Diiodo-3-methylpentane
• CAS: 51174-46-0
• 化学式: C₆H₁₂I₂
• 分子量: 337.97
• InChiKey: JZQMFKNWCOSKMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903399090

反应信息

• 作为反应物：
  描述：

  1,5-二碘-3-甲基戊烷 在 magnesium 作用下， 以 1,4-二氧六环 、 乙醚 为溶剂， 反应 3.5h， 生成 5-methyl-8-hexadecyn-1-ol
  参考文献：
  名称：

  摘要：

  Difficulties in isolating and purifying antibiotic fatty acids from culture filtrates of Pseudozyma flocculosa, a biocontrol agent against powdery mildew, have been limiting factors in studying the properties and understanding the mode of action of the biocontrol agent. We report a new protocol for synthesizing (Z)-9-heptadecenoic and for the first time synthesis of (Z)-6-methyl-9-heptadecenoic acids, two antibiotic fatty acids produced by P. flocculosa. This allowed reproducible and quantifiable means of assaying biological activity of the molecules. In these bioassays, both molecules exhibited antifungal activity corresponding to their expected potency. These new developments should facilitate further studies aimed at deciphering the ecological properties of P. flocculosa.

  DOI：

  10.1023/a:1005464326573
• 作为产物：
  描述：

  3-甲基戊二酸酐 在 lithium aluminium tetrahydride 、 三溴化磷 、 sodium iodide 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 25.0h， 生成 1,5-二碘-3-甲基戊烷
  参考文献：
  名称：

  摘要：

  Difficulties in isolating and purifying antibiotic fatty acids from culture filtrates of Pseudozyma flocculosa, a biocontrol agent against powdery mildew, have been limiting factors in studying the properties and understanding the mode of action of the biocontrol agent. We report a new protocol for synthesizing (Z)-9-heptadecenoic and for the first time synthesis of (Z)-6-methyl-9-heptadecenoic acids, two antibiotic fatty acids produced by P. flocculosa. This allowed reproducible and quantifiable means of assaying biological activity of the molecules. In these bioassays, both molecules exhibited antifungal activity corresponding to their expected potency. These new developments should facilitate further studies aimed at deciphering the ecological properties of P. flocculosa.

  DOI：

  10.1023/a:1005464326573

文献信息

• MACROCYCLIC INHIBITORS OF JAK
  申请人：Jahangir Alam

  公开号：US20110071179A1

  公开（公告）日：2011-03-24

  The present invention relates to the use of novel macrocyclic compounds of Formula I, wherein the variables Q, Q 1 , Q 2 , Q 3 , and Q 4 are defined as described herein, which inhibit JAK and are useful for the treatment of auto-immune and inflammatory diseases.

  本发明涉及使用式I的新型大环化合物，其中变量Q、Q1、Q2、Q3和Q4如本文所述定义，这些化合物抑制JAK并且适用于治疗自身免疫和炎症性疾病。
• Total synthesis of (±)-seychellene
  作者：Narihiko Fukamiya、Michiharu Kato、Akira Yoshikoshi

  DOI：10.1039/p19730001843

  日期：——

  The total synthesis of (±)-seychellene (4,7,8-trimethyl-11-methylenetricyclo[5.3.1.03,8]undecane)(I) from2,3-di-methylcyclohex-2-en-1-one (XIV) is described. The ketone (XIV) was converted into 2-methyl-2-(3-methyl-5-iodopentyl)-3-methylenecyclohexan-1-one (XV), which gave 2-methyl-2-(3-methyl-5-iodopentyl)-3-bromo-methylcyclohexa-3,5-dien-1-one (XIX) with N-bromosuccinimide. Treatment of bromo-ketone

  由（2,3-di-methylcyclohex-2-en-1-one（（））合成（±）-seychellene（4,7,8-三甲基-11-亚甲基三环[5.3.1.0 3,8 ]十一烷）（I）（ XIV）被描述。将酮（XIV）转化为2-甲基-2-（3-甲基-5-碘戊基）-3-亚甲基环己-1--1-酮（XV），得到2-甲基-2-（3-甲基-5-碘代戊基）-3-溴代甲基环己-3,5-二烯-1-酮（XIX）与N-溴代琥珀酰亚胺。用氯化铬（II），然后用酸处理溴代酮（XIX），得到2,3-二甲基-2-（3-甲基-5-碘戊基）环己-3,5-二烯-1-酮（XXI）。从二烯酮（XXI）获得2，3-二甲基-2-（3-甲基-5-二甲基氨基戊基）环己基3,5-二烯-1-酮（XXII）并被氧化；裂解生成的N-氧化物，生成4,7,8-三甲基三环-[5.3.1.0 3,8] undec-9-en-11-one（VII
• NORBORNENE-TYPE POLYMERS HAVING QUATERNARY AMMONIUM FUNCTIONALITY
  申请人：Bell Andrew

  公开号：US20110143260A1

  公开（公告）日：2011-06-16

  Embodiments of the present disclosure encompass vinyl addition and ROMP polymers having at least one type of repeating unit that encompasses a comprise N + (CH 3 ) 3 OH − moiety. Other embodiments in accordance with the disclosure include alkali anion-exchange membranes (AAEMs) made from one of such polymers, anion fuel cells (AFCs) that encompass such AAEMs and components of such AFCs, other than the AAEM, that encompass one of such polymers.

  本公开的实施例涵盖具有至少一种重复单元的乙烯加成和ROMP聚合物，该重复单元包括一个包含N+（CH3）3OH−基团的组分。根据本公开的其他实施例，还包括由此类聚合物之一制成的碱性阴离子交换膜（AAEMs），包括这样的AAEM的阴离子燃料电池（AFCs）以及包括这样的聚合物之一的AFC的组件，除了AAEM。
• <b>Proximity Effects. XXXV. Stereospecific Synthesis and Acetolysis of <b><i>cis</i></b>- and <b><i>trans</i></b>-5-Methylcyclooctyl Tosylates</b>
  作者：Arthur C. Cope、David M. Gale

  DOI：10.1021/ja00906a006

  日期：1963.12
• US4070461A
  申请人：——

  公开号：US4070461A

  公开（公告）日：1978-01-24