A modulator of PDE1A and/or PDE1C can be used as a medicament, in particular in the prevention or treatment of synucleinopathies, such as multiple system atrophy, dementia with Lewy bodies, Parkinson's disease, pure autonomic failure, rapid eye movement sleep behavior disorder, inherited synucleinopathies caused by mutations or multiplications of the SNCA gene, or synucleinopathies caused by mutations in other genes including, but not limited to, GBA, LRRK2 and PARK2.
PDE1A 和/或 PDE1C 的调节剂可用作药物,特别是用于预防或治疗突触核蛋白病,如多发性系统萎缩症、路易体痴呆症、帕
金森病、纯自律神经衰竭、快速眼动睡眠行为障碍、由 SNCA
基因突变或增殖引起的遗传性突触核蛋白病,或由其他
基因突变引起的突触核蛋白病,包括但不限于 GBA、LRRK2 和 PARK2。