申请人:Aronex Pharmaceuticals, Inc.
公开号:US05994321A1
公开(公告)日:1999-11-30
A series of guanine analogs and physiological salts thereof, which are useful as virus inhibitors and as antiviral agents in the treatment of viral disease, having the basic structures of: ##STR1## wherein B is H, CH.sub.3 or NH.sub.2 ; C is NH.sub.2 or SCH.sub.3 ; D is N or CH; E is O, S or Se; and G is selected from a group consisting of alkanes, alkenes, ethers, esters, hydrocarbons, amines and heterocyclic compounds, is herein disclosed. In I and III, A is O, S or Se while in II, A is NH.sub.2, OH, NHOH, OCH.sub.3 or SCH.sub.3. In I and II, F is 0, S or Se, while in III, F is F is 0, S, Se or NH. These compounds may be formulated with a physiological carrier, and used either alone or in combination with, for example, acyclovir or ganciclovir or another therapeutic agent, for the treatment of conditions resulting from viral infections.
一系列
鸟嘌呤类似物及其生理盐,可用作病毒
抑制剂和抗病毒剂,用于治疗病毒性疾病,具有以下基本结构:##STR1## 其中B为H、CH.sub.3或NH.sub.2;C为NH.sub.2或SCH.sub.3;D为N或CH;E为O、S或Se;G选自
烷烃、烯烃、醚、酯、碳氢化合物、胺和
杂环化合物组成的一组。在I和III中,A为O、S或Se,而在II中,A为NH.sub.2、OH、NHOH、OCH.sub.3或SCH.sub.3。在I和II中,F为O、S或Se,而在III中,F为O、S、Se或NH。这些化合物可以与生理载体配制,并单独使用或与
阿昔洛韦或甘
氟韦等其他治疗剂联合使用,用于治疗病毒感染引起的疾病。