2-(2-氯乙氧基)乙酸甲酯 | 83881-47-4

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 羧酸酯及其衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-(2-氯乙氧基)乙酸甲酯
• 中文别名: (2-氯乙氧基)-乙酸甲酯
• 英文名称: methyl 2-(2-chloroethoxy)acetate
• 英文别名: (2-Chloro-ethoxy)-acetic acid methyl ester
• CAS: 83881-47-4
• 化学式: C₅H₉ClO₃
• mdl: MFCD09030969
• 分子量: 152.578
• InChiKey: RDFIZBYHUOHTQI-UHFFFAOYSA-N

物化性质

• 沸点：
  98-99 °C(Press: 19 Torr)
• 密度：
  1.2081 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2918990090
• 包装等级：
  III
• 危险类别：
  8,6.1
• 危险性防范说明：
  P501,P270,P264,P280,P362+P364,P332+P313,P301+P310+P330,P302+P352+P312,P305+P351+P338+P310,P405
• 危险品运输编号：
  2922
• 危险性描述：
  H301,H312,H316,H318

制备方法与用途

2-(2-氯乙氧基)乙酸甲酯是一种有用的有机合成研究化学品，广泛应用于各种化学过程。

反应信息

• 作为反应物：
  描述：

  2-(2-氯乙氧基)乙酸甲酯 在 一水合肼 作用下， 生成 4-aminomorpholin-3-one
  参考文献：
  名称：

  Shavel et al., Journal of the American Pharmaceutical Association (1912), 1953, vol. 42, p. 402,405

  摘要：

  DOI：
• 作为产物：
  描述：

  5-chloro-2,3-dihydro-1,4-dioxin 、 甲醇 反应 1.5h， 生成 2-(2-氯乙氧基)乙酸甲酯
  参考文献：
  名称：

  Reactions of 2-Chlorodioxene with Alcohols, Phenols, and Acids

  摘要：

  DOI：

  10.1021/jo01069a034
• 作为试剂：
  描述：

  (-)-1-[(4-氯苯基)苯甲基]哌嗪 、 2-(2-氯乙氧基)乙酸甲酯 在 2-(2-氯乙氧基)乙酸甲酯 作用下， 以37.8的产率得到
  参考文献：
  名称：

  Enantjomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine

  摘要：

  本发明提供了一种治疗过敏症的方法，通过向患者投予右旋二氯盐2-[2-[4-[(4-氯苯基)苯甲基]-1-哌嗪基]乙氧基]乙酸的有效量。该治疗在左旋二氯盐2-[2-[4-[(4-氯苯基)苯甲基]-1-哌嗪基]乙氧基]乙酸的缺席下进行。

  公开号：

  US20070142400A1

文献信息

• Substituted [2-(1-piperazinyl)ethoxy]methyl compounds
  申请人：UCB, S.A.

  公开号：US06140501A1

  公开（公告）日：2000-10-31

  Novel substituted [2-(1-piperazinyl)ethoxy]methyl compounds. The present invention related to novel substituted [2-(1-piperazinyl)-ethoxy]methyl compounds of formula ##STR1## in which R.sub.1 represents a --CONH.sub.2, --CN, --COOH, --COOM or --COOR.sub.3 group, M being an alkali metal and R.sub.3 being an alkyl radical having from 1 to 4 carbon atoms; and R.sub.2 represents a hydrogen atom or a group --COR.sub.4 or --R.sub.5, where R.sub.4 is chosen from the groups --OR.sub.6 or --R.sub.7, in which R.sub.5 represents an allyl or alkylaryl radical, R.sub.6 represents a linear or branched alkyl radical having from 1 to 4 carbon atoms, a haloalkyl, alkylaryl, alkylnitroaryl or alkylhaloaryl radical, and R.sub.7 represents a haloalkyl radical, to a process for the preparation of these compounds, and to their use for the preparation of compounds which are themselves valuable intermediates for the preparation of 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid or 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]-acetic acid and/or pharmaceutically acceptable salts thereof.

  新型取代[2-(1-哌嗪基)乙氧基]甲基化合物。本发明涉及一种新型取代[2-(1-哌嗪基)-乙氧基]甲基化合物，其化学式为##STR1##其中R.sub.1代表--CONH.sub.2，--CN，--COOH，--COOM或--COOR.sub.3基团，M为碱金属，R.sub.3为具有1至4个碳原子的烷基基团；R.sub.2代表氢原子或--COR.sub.4或--R.sub.5基团，其中R.sub.4选自--OR.sub.6或--R.sub.7基团，其中R.sub.5代表烯丙基或烷基芳基基团，R.sub.6代表具有1至4个碳原子的直链或支链烷基基团，卤代烷基，烷基芳基，烷基硝基芳基或烷基卤代芳基基团，R.sub.7代表卤代烷基基团，一种用于制备这些化合物的方法，以及它们用于制备2-[2-[4-[(4-氯苯基)苯甲基]-1-哌嗪基]乙氧基]-乙酸或2-[2-[4-[双(4-氟苯基)甲基]-1-哌嗪基]乙氧基]-乙酸和/或其药学上可接受的盐的化合物的用途。
• Process for the preparation of {2-[4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy} acetic acid and novel intermediates therefor
  申请人：——

  公开号：US20030092911A1

  公开（公告）日：2003-05-15

  The invention refers to a novel process for the preparation of cetirizine of formula (I) as well as to novel {2-[4-(&agr;-phenyl-p-chloro-benzyl)piperazin-1-yl]ethoxy}acetamides of formula II, wherein R 1 and R 2 represent, independently, a C 1-4 alkyl group optionally substituted by a phenyl group, a C 2-4 alkenyl group or a cyclohexyl group, or R 1 and R 2 form together with the adjacent nitrogen atom a morpholino group. According to the novel process, an acetamide of formula (II) is hydrolized, if desired in the presence of a phase transfer catalyst, to obtain cetirizine.

  该发明涉及一种新型制备化学式（I）的右美沙芬的方法，以及一种新型化学式II的{2-[4-(&agr;-苯基-p-氯苄基)哌嗪-1-基]乙氧}乙酰胺，其中R1和R2分别独立表示C1-4烷基，可选择地被苯基取代，C2-4烯基或环己基，或者R1和R2与相邻的氮原子一起形成吗啡基团。根据这种新型方法，化学式（II）的乙酰胺在需要时在相转移催化剂的存在下水解，以获得右美沙芬。
• Piperidine derivative, method for preparation thereof, and a
  申请人：Hokuriku Pharmaceutical Co., Ltd.

  公开号：US05153207A1

  公开（公告）日：1992-10-06

  A piperidine derivative represented by the following general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R.sub.3 represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an --A--O--B-- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

  以下是通用公式（I）所代表的哌啶衍生物：##STR1## 其中R.sub.1和R.sub.2相同或不同，每个独立代表氢原子、卤素原子、低碳基团或低碳氧基团；R.sub.3代表氢原子或低碳基团；X代表氧原子或硫原子；Y代表1至7个碳原子的烷基基团，该基团可以选择性地用低碳基团取代，或者Y代表--A--O--B--基团，其中A和B相同或不同，每个独立代表1至3个碳原子的烷基基团，该基团可以选择性地用低碳基团取代。还公开了公式（I）化合物的药理学可接受盐、包含公式（I）化合物的抗组胺和抗过敏剂、包含公式（I）化合物的药物组合物，以及通过给予公式（I）化合物治疗过敏性疾病的方法。
• 14B(R) isomers of novel tetracyclic compounds having anti-allergic and
  申请人：Sankyo Company, Limited

  公开号：US05476848A1

  公开（公告）日：1995-12-19

  An optically active compound of formula (I): ##STR1## in which R.sup.3 represents groups of formula --A--COOR.sup.4, wherein A represents alkylene groups having 3 or 5 carbon atoms and R.sup.4 represents hydrogen or an alkyl group having 1 to 4 carbon atoms; or a pharmaceutically acceptable salt thereof.

  式(I)的光学活性化合物：##STR1## 其中R.sup.3代表式--A--COOR.sup.4的基团，其中A代表具有3或5个碳原子的烷基基团，R.sup.4代表氢或具有1至4个碳原子的烷基基团；或其药用可接受盐。
• Tetracyclic compounds having anti-allergic and anti-asthmatic activities
  申请人：Sankyo Company, Limited

  公开号：US05362725A1

  公开（公告）日：1994-11-08

  Compounds of formula (I): ##STR1## in which: Q is nitrogen or .dbd.CH--; R.sup.1 and R.sup.2 are hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl or halogen; and R.sup.3 is a substituted alkyl groups or a pharmaceutically acceptable salt thereof have valuable anti-allergic and anti-asthmatic activities. The compounds are prepared by reacting a corresponding compound where R.sup.3 is replaced by a hydrogen atom with a compound to introduce the group R.sup.3.

  式(I)的化合物：##STR1##其中：Q是氮或.dbd.CH--; R.sup.1和R.sup.2是氢、烷基、烷氧基、羟基、三氟甲基或卤素；R.sup.3是取代烷基基团或其药用可接受盐，具有有价值的抗过敏和抗哮喘活性。通过将R.sup.3被氢原子取代的相应化合物与引入基团R.sup.3的化合物反应制备这些化合物。