2-乙基丁酸钠 | 2452-14-4

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-乙基丁酸钠
• 中文别名: 萘-1,3-二胺
• 英文名称: sodium 2-ethylbutanoate
• 英文别名: 2-ethylbutyric acid sodium salt；sodium 2-ethylbutyrate；sodium diethylacetate；sodium salt of 2-ethylbutyric acid；sodium;2-ethylbutanoate
• CAS: 2452-14-4
• 化学式: C₆H₁₁O₂*Na
• 分子量: 138.142
• InChiKey: BLSRNVDCHVKXSO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.82
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-乙基丁酸钠 在 正丁基锂 、 氯化亚砜 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 10.75h， 生成 2,2-diethyl-5-chlorovaleric acid chloride
  参考文献：
  名称：

  METHOD OF PRODUCING ACID HALIDE AND ACID HALIDE

  摘要：

  生产酸卤化物的方法，包括：将由以下式（III）表示的化合物与一种碱性化合物和由以下式（IV）表示的化合物反应，以得到由以下式（II）表示的化合物；然后将由式（II）表示的化合物与酸卤化剂反应，得到由以下式（I）表示的化合物。

  公开号：

  US20120053365A1
• 作为试剂：
  描述：

  2-乙基丁醛 在 氧气 、 2-乙基丁酸钠 作用下， 生成 2-乙基丁酸
  参考文献：
  名称：

  DE732720

  摘要：

  公开号：

文献信息

• Reactivity and selectivity in the inhibition of elastase by 3-oxo-β-sultams and in their hydrolysis
  作者：Wing-Yin Tsang、Naveed Ahmed、Karl Hemming、Michael I. Page

  DOI：10.1039/b713899g

  日期：——

  leaving group, whereas the enzyme reaction occurs at the acyl centre. Increasing selectivity between these two reactive centres was explored by examining the effect of substituents on the reactivity of 3-oxo-beta-sultam towards hydrolysis and enzyme inhibition. The inhibition activity against porcine pancreatic elastase has a much higher sensitivity to substituent variation than does the rate of alkaline

  3-氧代-β-sultams都是β-sultams和β-内酰胺，并且是一类新的时间依赖性弹性蛋白酶抑制剂。抑制作用涉及活性位点丝氨酸的酰化，形成具有瞬时稳定性的共价酶抑制剂加合物，该活性位丝氨酸是由3-氧代-β-杜鹃花的羰基中心处的取代，CN裂变和磺酰胺的排出而引起的。铅化合物N-苄基-4,4-二甲基-3-氧代-β-苏丹酰胺1是一种有效的猪胰弹性蛋白酶抑制剂，其二级速率常数为768 M（-1）s（-1）在pH值为6的情况下，还具有很高的化学反应活性，在相同pH值的水中水解仅需6分钟即可达到半衰期。有趣的是，在磺酰基中心发生3-氧代-β-杜鹃花的水解，发生SN裂变并驱逐酰胺离去基团，而酶反应发生在酰基中心。通过检查取代基对3-氧代-β-苏丹草对水解和酶抑制的反应性的影响，探索了这两个反应中心之间选择性的提高。对猪胰弹性蛋白酶的抑制活性比碱性水解速率对取代基变化的敏感性高得多。对于抑制作用，在
• [EN] PROCESS FOR THE PREPARATION OF CEFOTAXIME SODIUM<br/>[FR] PROCEDE DE PREPARATION DE CEFOTAXIME SODIQUE
  申请人：ORCHID CHEMICALS & PHARM LTD

  公开号：WO2004063203A1

  公开（公告）日：2004-07-29

  An improved process for the preparation of the sterile cefotaxime sodium of formula (I), from the compound of formula (II).

  一种改进的方法，用于从公式(II)的化合物制备公式(I)的无菌头孢噻肟钠。
• Process for the preparation of reactive penicillanic acid and
  申请人：Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.

  公开号：US04171303A1

  公开（公告）日：1979-10-16

  This invention relates to a process for the preparation of acid amides having the formula (I) or their salts ##STR1## wherein R.sup.1 is hydrogen or an easily removable ester-forming or salt-forming group, preferably a trialkylamino, trialkylsilyl, trichloroethyl, acetoxymethyl, phenacyl, substituted phenacyl, substituted phenyl or benzyl group, R.sup.2 is hydrogen, alkyl group, alkenyl group, alkyl group having an aryl or heterocyclic (preferably furyl or thienyl)-substituent, an aryl group having an alkyl substituent (preferably xylyl), or an aryl, aralkyl or heterocyclic group, (preferably a phenyl, thienyl, or furyl group) which can have one or more substituents, R.sup.3 is hydrogen, or substituted or unsubstituted aryl, alkyl, cycloalkyl or aralkyl group, and X is a group of one of the formulae ##STR2## according to the invention an amine of the formula (II), ##STR3## wherein R.sup.4 is an easily removable ester-forming group, preferably a trialkylamino, trialkylsilyl, trichloroethyl, acetoxymethyl, phenacyl, substituted phenacyl, substituted phenyl or benzyl group, or a salt formed preferably with an alkali metal or a trialkylamine, is acylated with an ester of the formula (III), ##STR4## wherein R.sup.5 is a substituted or unsubstituted aryl, alkyl, cycloalkyl or aralkyl group, and, if desired, substituents R.sup.4 and/or R.sup.5 of the obtained product can be split off, and/or, if desired, the obtained product is converted into its salt or a salt is converted into the free acid.

  本发明涉及一种制备酸酰胺化合物(I)或其盐的方法，其中R1为氢或易于去除的酯基或盐基，优选为三烷基胺基、三烷基硅基、三氯乙基、乙酰氧甲基、苯乙酰基、取代苯乙酰基、取代苯基或苄基；R2为氢、烷基、烯基、带有芳基或杂环基(优选为呋喃基或噻吩基)的烷基、带有烷基取代基(优选为二甲苯基)的芳基、芳基、芳基烷基或杂环基(优选为苯基、噻吩基或呋喃基)；R3为氢、取代或未取代的芳基、烷基、环烷基或芳基烷基；X为以下公式之一的基团之一：其中本发明的方法为将以下式(II)的胺基化合物：其中R4为易于去除的酯基，优选为三烷基胺基、三烷基硅基、三氯乙基、乙酰氧甲基、苯乙酰基、取代苯乙酰基、取代苯基或苄基，或与碱金属或三烷基胺形成的盐，与以下式(III)的酯化合物酰化：其中R5为取代或未取代的芳基、烷基、环烷基或芳基烷基，所得产物的R4和/或R5取代基可被分离，或如有需要，所得产物可转化为其盐或将盐转化为游离酸。
• A process for preparing alpha-lithio derivatives and a process for preparing carboxylic acids using them
  申请人：STERWIN AG.

  公开号：EP0033233A1

  公开（公告）日：1981-08-05

  The present invention relates to a process for preparing a-lithio derivatives of the general formula: wherein R' and R", which may be the same or different, each represent a hydrogen atom, an alkyl, alkoxyalkyl, dialkylaminoalkyl, aralkyl, alkoxy or dialkylamino group, or a monocyclic aryl ring optionally substituted by one or more alkyl, alkoxy, dialkylamino or monocyclic aryl groups and M represents an alkali metal atom, and to their use. In the process of the invention an acid of the general formula: wherein R' and R" are as defined above or a salt thereof is reacted with lithium and a dialkylamine in the presence of an aromatic polynuclear hydrocarbon or an unsaturated hydrocarbon comprising an aliphatic or alicyclic chain containing a double bond conjugated either with a second double bond in the chain or with an aromatic moiety. The reactants are brought together so that there is substantially no lithium dialkylamide formed before the acid is introduced. The thus formed derivatives can be reacted with a compound A-X where A is an alkyl or alkenyl group and X is halogen or -O-SO2-R3 where R' is alkyl or aryl to form an acid of the general formula: where R' and R" are as defined above.

  本发明涉及一种制备通式为 a-硫代衍生物的工艺： 其中R'和R "可以相同或不同，各自代表氢原子、烷基、烷氧基烷基、二烷基氨基烷基、芳基、烷氧基或二烷基氨基基团，或任选被一个或多个烷基、烷氧基、二烷基氨基或单环芳基取代的单环芳基环，M代表碱金属原子，以及它们的用途。在本发明的工艺中，通式为 其中 R' 和 R "如上定义或其盐与锂和二烷基胺在芳香族多核烃类或不饱和烃类的存在下反应。将反应物混合在一起，以便在引入酸之前基本上不形成二烷基酰胺锂。 由此形成的衍生物可与化合物 A-X 反应，其中 A 为烷基或烯基，X 为卤素或-O-SO2-R3，其中 R' 为烷基或芳基，形成通式如下的酸： 其中 R' 和 R" 如上定义。
• INTERLAYER FILM FOR LAMINATED GLASS, AND LAMINATED GLASS
  申请人：SEKISUI CHEMICAL CO., LTD.

  公开号：EP3909929A1

  公开（公告）日：2021-11-17

  An interlayer film for laminated glass of the present invention comprises a thermoplastic resin, a carboxylic acid, and an alkali (alkaline earth) metal, wherein, when a molar concentration per unit volume of the alkali (alkaline earth) metal in the interlayer film for laminated glass, measured by ICP atomic emission spectrophotometry is A (mol/m3); a molar concentration per unit volume of the carboxylic acid in the interlayer film for laminated glass, measured by GC-MS is B (mol/m3); a molar concentration per unit volume of the carboxylic acid in the interlayer film for laminated glass, measured by GC-MS after a hydrochloric acid aqueous solution is added to the interlayer film for laminated glass to be left at 23°C for 12 hours is Y; and a molar concentration per unit volume of the carboxylic acid, obtained by subtracting the molar concentration B from the concentration Y is D (mol/m3), the molar concentration A is more than 0.35 mol/m3 and less than 1.00 mol/m3, and a carboxylic acid isolation ratio (1) represented by (1 - D/A) × 100 is 40% or less.

  本发明的夹层玻璃用中间膜由热塑性树脂、羧酸和碱（碱土）金属组成，其中，当通过 ICP 原子发射分光光度法测量夹层玻璃用中间膜中碱（碱土）金属的摩尔浓度单位体积为 A（mol/m3）时；通过 GC-MS 测量夹层玻璃用中间膜中羧酸的摩尔浓度单位体积为 B（mol/m3）时；将盐酸水溶液加入夹层玻璃用中间膜并在 23°C 下放置 12 小时后，用 GC-MS 测得的夹层玻璃用中间膜中羧酸的摩尔浓度为 Y；从浓度 Y 中减去摩尔浓度 B 得到的羧酸的摩尔浓度为 D（mol/m3），摩尔浓度 A 大于 0.35摩尔/立方米且小于1.00摩尔/立方米，羧酸分离率（1）由（1-D/A）×100表示，等于或小于40%。