3-deoxy-1,2:5,6-di-O-isopropylidene-3-C-methyl-3-C-vinyl-α-D-allofuranose | 103516-20-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-deoxy-1,2:5,6-di-O-isopropylidene-3-C-methyl-3-C-vinyl-α-D-allofuranose
• 英文别名: (3aR,5S,6R,6aR)-5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-ethenyl-2,2,6-trimethyl-5,6a-dihydro-3aH-furo[2,3-d][1,3]dioxole
• CAS: 103516-20-7
• 化学式: C₁₅H₂₄O₅
• 分子量: 284.353
• InChiKey: PTWIULRMQJSWHQ-BJIWRROBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-deoxy-1,2:5,6-di-O-isopropylidene-3-C-methyl-3-C-vinyl-α-D-allofuranose 在 吡啶 、 4-二甲氨基吡啶 、 sodium periodate 、 Amberlite IR-120 (H+) 、 sodium hydride 、 二异丁基氢化铝 、 臭氧 、 溶剂黄146 、 三乙胺 、 三苯基膦 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 甲苯 、 苯 为溶剂， 反应 122.5h， 生成 (2R,3R,4S,5R)-3-<(E)-3-(benzyloxy)-1-propenyl>-5-<<(2,2-dimethylpropionyl)oxy>methyl>-4-hydroxy-2-methoxy-3-methyltetrahydrofuran
  参考文献：
  名称：

  Total synthesis of (+)-asteltoxin1

  摘要：

  DOI：

  10.1016/s0040-4020(01)82015-9
• 作为产物：
  描述：

  1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 在 palladium on activated charcoal 、 4 A molecular sieve 、 二异丁基氢化铝 、 丙酸 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 、 苯甲腈 、 甲苯 、 苯 为溶剂， 反应 15.5h， 生成 3-deoxy-1,2:5,6-di-O-isopropylidene-3-C-methyl-3-C-vinyl-α-D-allofuranose
  参考文献：
  名称：

  Ortho ester Claisen rearrangements of three 3-C-(hydroxymethyl)methylene derivatives of hexofuranose: stereoselective introduction of a quaternary center on C-3 of D-ribo-, L-lyxo-, and D-arabino-hexofuranoses

  摘要：

  DOI：

  10.1021/jo00383a005

文献信息

• INTRODUCTION OF<i>gem</i>-DILKYL GROUP TO HEXOFURANOSE BY ORTHO ESTER CLAISEN REARRANGEMENT
  作者：Kin-ichi Tadano、Yoko Idogaki、Hirohiko Yamada、Tetsuo Suami

  DOI：10.1246/cl.1985.1925

  日期：1985.12.5

  The ortho ester Claisen rearrangement of D-ribo- or L-lyxo- hexofuranose derivative which possesses an allyl alcohol functionality on C-3, proceeds stereoselectively to give a 3-C-dialkylated product. The stereochemistry of a newly introduced quaternary center of the product was unambiguously established by a chemical modification.

  在 C-3 上具有烯丙醇官能团的 D-核糖或 L-lyxo-己呋喃糖衍生物的原酸酯克莱森重排立体选择性地进行，得到 3-C-二烷基化产物。产品新引入的四元​​中心的立体化学是通过化学修饰明确建立的。
• Stereoselective synthesis of the bis(tetrahydrofuran) moiety (C-1 to C-9) of (+)-asteltoxin, a novel mycotoxin from aspergillus stellatus
  作者：Kin-ichi Tadano、Hirohiko Yamada、Yoko Idogaki、Seiichiro Ogawa、Tetsuo Suami

  DOI：10.1016/s0040-4039(00)80175-6

  日期：——

  The bis(tetrahydrofuran) moiety of (+)-asteltoxin which possesses six asymmetric carbons has been synthesized stereoselectively. The synthesis was started from a highly functionalized tetrahydrofuran prepared from D-glucose.

  立体选择性地合成了具有六个不对称碳的（+）-asteltoxin的双（四氢呋喃）部分。从由D-葡萄糖制备的高度官能化的四氢呋喃开始合成。
• A total synthesis of (+)-eremantholide A
  作者：Ken-ichi Takao、Hiroshi Ochiai、Takahiko Hashizuka、Hirokazu Koshimura、Kin-ichi Tadano、Seiichiro Ogawa

  DOI：10.1016/0040-4039(95)00066-l

  日期：1995.2

  Stereoselective and enantiospecific total synthesis of (+)-eremantholide A (1) is described. The present total synthesis features 1) regio- and stereoselective radical carbocyclization of D-glurose-derived gamma-lactone 7, and 2) a nine-membered ring formation by the coupling reaction of bicyclic triflate 18 and known furanone 19 followed by a vinylogous aldol reaction.
• Novel Total Synthesis of (+)-Eremantholide A
  作者：Ken-ichi Takao、Hiroshi Ochiai、Ken-ichi Yoshida、Takahiko Hashizuka、Hirokazu Koshimura、Kin-ichi Tadano、Seiichiro Ogawa

  DOI：10.1021/jo00130a017

  日期：1995.12

  Stereoselective total synthesis of (+)-eremantholide A (1), a cytotoxic furanoheliangolide sesquiterpene, was accomplished in an enantiospecific fashion. The total synthesis featured the following three key synthetic strategies. (1) Intramolecular cyclization of carbon-radicals derived from xanthates 19a or 19b proceeded regio- and stereoselectively in an exclusive 5-exo-dig mode to provide bicyclic lactones 20a or 20b. Further functional group manipulations of 20a and 20b efficiently afforded a highly substituted 3,7-dioxabicyclo[3.3.0]octan-2-one derivative 34, which served as a synthetic equivalent to the A/B ring system in 1. (2) Alkylation of the enolate of 3(2H)-furanone 36 with triflate 35 was thoroughly investigated to maximize formation of the C-alkylated diastereomers, either 10R-isomer 37 or 10S-isomer 38. It was found that choice of the base, solvent, and/or additive was critical to the diastereoselectivity. Furthermore, the 10R-isomer 50 was also prepared in increased yield and improved diastereoselectivity by coupling 36 with A/B ring equivalent 49. (3) In a later stage of the total synthesis, construction of the strained 11-oxabicyclo-[6.2.1]undeca-2,10-dien-9-one system (the C/D ring) was accomplished by means of an intramolecular vinylogous aldol reaction of aldehyde 52, prepared from 10R-isomer 40, followed by base-catalyzed beta-elimination of the corresponding mesylates 54. On the other hand, by employing analogous reaction conditions, the 10S-isomer 56 was transformed into unnatural (-)-10-epi-eremantholide A (61).
• Synthesis and Application of 3,3-Spirocyclopropane Derivatives Obtained from 1,2:5,6-Di-<i>O</i>-Isopropylidene-α-D-Glucofuranose
  作者：M. K. Gurjar、B. V. N. B. S. Sharma、B. Venkateswara Rao

  DOI：10.1080/07328309808001887

  日期：1998.9.1

  3,3-Spirocyclopropane derivatives (5 and 7) were prepared by three different methods of cyclopropanation starting from 1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose (2). Subsequent radical induced cyclopropane ring opening reaction stereospecifically provided the 3-C-allyl derivative (9). However, activation of the cyclopropyl ring through the aldehyde (10) followed by hydrogenation gave a quaternary chiral derivative (11) which was elaborated to the versatile intermediate (1) by using Bamford-Stevens reaction.