6-[2-(dimethylamino)ethoxy]-2-dodecyl-1-hydroxy-4-quinolone | 1217894-23-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[2-(dimethylamino)ethoxy]-2-dodecyl-1-hydroxy-4-quinolone
• 英文别名: 6-(2-Dimethylaminoethyloxy)-2-dodecyl-1-hydroxy-quinolin-4-one；6-[2-(dimethylamino)ethoxy]-2-dodecyl-1-hydroxyquinolin-4-one
• CAS: 1217894-23-9
• 化学式: C₂₅H₄₀N₂O₃
• 分子量: 416.604
• InChiKey: MBBLOWDYRWFJJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  30
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  53
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-溴十一烷 在 正丁基锂 、 palladium 10% on activated carbon 、 四丁基氟化铵 、 氢气 、 sodium hydride 、 溶剂黄146 、 二异丙胺 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二苯醚 、 乙醇 、 正己烷 、 二氯甲烷 、 水 、 二甲基亚砜 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， -78.0~260.0 ℃ 、100.0 kPa 条件下， 反应 57.3h， 生成 6-[2-(dimethylamino)ethoxy]-2-dodecyl-1-hydroxy-4-quinolone
  参考文献：
  名称：

  Synthesis of Novel 1-Hydroxyquinolones with High Anti-Toxoplasma Activity

  摘要：

  All for the treatment of malaria and toxoplasmosis the novel hydroxyquinolones 2-5 were prepared by reaction of aniline and hydroxyaniline, respectively and the beta-ketoesters 10a-c. As products the quinolones 8 and 15, respectively were obtained. Benzylation, oxidation and hydrogenation then led to the desired substances. Compound 2 has a similar anti-malaria activity as the approved drug Atovaquone.

  DOI：

  10.3987/com-10-s(e)9

文献信息

• Synthesis of Novel 1-Hydroxyquinolones with High Anti-Toxoplasma Activity
  作者：Lutz F. Tietze、Ling Ma

  DOI：10.3987/com-10-s(e)9

  日期：——

  All for the treatment of malaria and toxoplasmosis the novel hydroxyquinolones 2-5 were prepared by reaction of aniline and hydroxyaniline, respectively and the beta-ketoesters 10a-c. As products the quinolones 8 and 15, respectively were obtained. Benzylation, oxidation and hydrogenation then led to the desired substances. Compound 2 has a similar anti-malaria activity as the approved drug Atovaquone.