2-肼基-3-苯基喹唑啉-4-酮 | 731-52-2

分子结构分类

有机化合物 - 有机杂环化合物 - 二氮杂萘

中文名称

2-肼基-3-苯基喹唑啉-4-酮

中文别名

——

英文名称

2-hydrazino-3-phenyl-3H-quinazolin-4-one

英文别名

2-hydrazino-3-phenylquinazolin-4(3H)-one；2-hydrazinyl-3-phenylquinazolin-4(3H)-one；2-hydrazinyl-3-phenylquinazolin-4-one

CAS

731-52-2

化学式

C₁₄H₁₂N₄O

mdl

MFCD00614682

分子量

252.275

InChiKey

VNBHFDXTDVKBRK-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

1.2
重原子数：

19
可旋转键数：

2
环数：

3.0
sp3杂化的碳原子比例：

0.0
拓扑面积：

70.7
氢给体数：

2
氢受体数：

3

SDS

SDS：a97890468aaff65f4415eb3dbe228256

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上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
3-苯基-2,4(1H,3H)-喹唑啉二酮	3-phenyl-2,4-(1H,3H)-quinazolinedione	603-23-6	C₁₄H₁₀N₂O₂	238.246
2-氯-3-苯基喹唑啉-4(3H-)-酮	2-chloro-3-phenylquinazolin-4(3H)-one	727-62-8	C₁₄H₉ClN₂O	256.691
3-苯基-2-硫代-2,3-二氢-4(1H)-喹唑啉酮	3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one	18741-24-7	C₁₄H₁₀N₂OS	254.312
2-甲硫基-3-苯基喹唑啉-4-酮	2-methylmercapto-3-phenyl-4(3H)-quinazolinone	73987-32-3	C₁₅H₁₂N₂OS	268.339
2-(乙硫基)-3-苯基喹唑啉-4(3H)-酮	2-ethylthio-3-phenyl-4-oxo-3,4-dihydroquinazoline	29745-27-5	C₁₆H₁₄N₂OS	282.366
——	2-(1-oxo-1-phenylethylthio)-3-phenylquinazolin-4(3H)-one	18741-33-8	C₂₂H₁₆N₂O₂S	372.447
——	2-{[2-(4-chlorophenyl)-2-oxoethyl]thio}-3-phenylquinazolin-4(3H)-one	307325-55-9	C₂₂H₁₅ClN₂O₂S	406.892
——	2-{[2-(4-bromophenyl)-2-oxoethyl]thio}-3-phenylquinazolin-4(3H)-one	30531-14-7	C₂₂H₁₅BrN₂O₂S	451.343

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	benzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone	3318-07-8	C₂₁H₁₆N₄O	340.384
——	2-(N'-4-chlorobenzylidenehydrazino)-3-phenyl-3H-quinazolin-4-one	66679-85-4	C₂₁H₁₅ClN₄O	374.829
——	4-Chlorobenzaldehyde (4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)hydrazone	——	C₂₁H₁₅ClN₄O	374.8
——	4-bromobenzaldehyde N-(3-phenyl-4-oxoquinazolin-2-yl)-hydrazone	304446-57-9	C₂₁H₁₅BrN₄O	419.28
——	2-thiophenealdehyde N-(3-phenyl-4-oxoquinazolin-2-yl)hydrazone	305850-34-4	C₁₉H₁₄N₄OS	346.412
——	2-(N'-4-methoxybenzylidenehydrazino)-3-phenyl-3H-quinazolin-4-one	86842-51-5	C₂₂H₁₈N₄O₂	370.411
——	2-furaldehyde N-(3-phenyl-4-oxoquinazolin-2-yl)hydrazone	1100765-58-9	C₁₉H₁₄N₄O₂	330.346
——	1-naphthaldehyde N-(3-phenyl-4-oxoquinazolin-2-yl)hydrazone	719281-98-8	C₂₅H₁₈N₄O	390.444
——	4-dimethylaminobenzaldehyde N-(3-phenyl-4-oxoquinazolin-2-yl)-hydrazone	322413-58-1	C₂₃H₂₁N₅O	383.453
——	2-(4-oxo-3-phenyl-3,4-dihydro-quinazolin-2-yl)-N'-phenyl-hydrazinecarbothioamide	67443-03-2	C₂₁H₁₇N₅OS	387.465
——	2-(N'-4-nitrobenzylidenehydrazino)-3-phenyl-3H-quinazolin-4-one	305850-37-7	C₂₁H₁₅N₅O₃	385.382
——	3-(phenyl)-2-[4-(4-methylphenyl)-thiosemicarbazone]-quinazolin-4-one	175688-59-2	C₂₂H₁₉N₅OS	401.492
——	3-(phenyl)-2-[4-(4-methoxyphenyl)-thiosemicarbazone]-quinazolin-4-one	1146963-27-0	C₂₂H₁₉N₅O₂S	417.491
——	2-(2-(3,4-dimethoxybenzylidene)hydrazinyl)-3-phenylquinazolin-4(3H)-one	304446-56-8	C₂₃H₂₀N₄O₃	400.437
3-苯基-2,4(1H,3H)-喹唑啉二酮	3-phenyl-2,4-(1H,3H)-quinazolinedione	603-23-6	C₁₄H₁₀N₂O₂	238.246
——	2-{N'-[5-Methyl-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-hydrazino}-3-phenyl-3H-quinazolin-4-one	——	C₂₃H₁₇N₅O₂	395.42
——	2-(5-oxo-3-phenyl-4,5-dihydropyrazol-1-yl)-3-phenylquinazolin-4(3H)-one	1427523-33-8	C₂₃H₁₆N₄O₂	380.406
——	(E)-2-((E)-(1-allyl-2-oxoindolin-3-ylidene)hydrazono)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one	1196151-02-6	C₂₅H₁₉N₅O₂	421.458
——	4-phenyl-1,2,4-triazolo<4,3-a>quinazolin-5(4H)-one	67811-46-5	C₁₅H₁₀N₄O	262.271
——	tetrazolo<1,5-a>-3-phenylquinazoline-4(3H)-one	59342-38-0	C₁₄H₉N₅O	263.258
——	4-phenyl-[1,2,4]triazolo[4,3-a]quinazoline-1,5(2H,4H)-dione	67629-33-8	C₁₅H₁₀N₄O₂	278.27
——	4-phenyl-5-oxo-1-thioxo-1,2,4,5-tetrahydro-s-triazolo<4,3-a>-quinazoline	67442-90-4	C₁₅H₁₀N₄OS	294.337
——	1-methyl-4-phenyl-1,2,4-triazolo<4,3-a>quinazolin-5(4H)-one	68357-48-2	C₁₆H₁₂N₄O	276.297
——	1-Chloromethyl-4-phenyl-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one	86662-62-6	C₁₆H₁₁ClN₄O	310.743
——	2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylquinazolin-4(3H)-one	121662-02-0	C₁₉H₁₆N₄O	316.362
——	1,4-diphenyl-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-one	86848-87-5	C₂₁H₁₄N₄O	338.368
——	1-Benzylsulfanyl-4-phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one	76462-03-8	C₂₂H₁₆N₄OS	384.461
——	(5-oxo-4-phenyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)-acetic acid ethyl ester	67476-03-3	C₁₉H₁₆N₄O₃	348.361
——	1-ethoxycarbonylmethylthio-4-phenyl-1,2,4-triazolo<4,3-a>quinazolin-5(4H)-one	86842-60-6	C₁₉H₁₆N₄O₃S	380.427
——	5-amino-1-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carbonitrile	1260163-48-1	C₁₈H₁₂N₆O	328.333
——	1-(4-methoxyphenyl)-4-phenyl-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-one	86842-55-9	C₂₂H₁₆N₄O₂	368.395
——	(E)-2-((E)-(5-methyl-2-oxoindolin-3-ylidene)hydrazono)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one	115781-73-2	C₂₃H₁₇N₅O₂	395.42
——	4-phenyl-1-o-tolyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one	1146963-29-2	C₂₂H₁₆N₄O	352.395
——	1-(2-chlorophenyl)-4-phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one	1146963-30-5	C₂₁H₁₃ClN₄O	372.813
——	2-(3-methyl-5-phenyl-1H-pyrazol-1-yl)-3-phenylquinazolin-4(3H)-one	1427523-31-6	C₂₄H₁₈N₄O	378.433

反应信息

作为反应物：

描述：

2-肼基-3-苯基喹唑啉-4-酮在一水合肼作用下，以异丙醇、正丁醇为溶剂，反应 16.0h，生成 3-氨基-2-肼基喹唑啉-4-酮

参考文献：

名称：

Kottke; Kuhmstedt; Grafe, Pharmazie, 1990, vol. 45, # 1, p. 30 - 33

摘要：

DOI：