2-(5-oxo-3-phenyl-4,5-dihydropyrazol-1-yl)-3-phenylquinazolin-4(3H)-one | 1427523-33-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(5-oxo-3-phenyl-4,5-dihydropyrazol-1-yl)-3-phenylquinazolin-4(3H)-one
• 英文别名: 2-(5-oxo-3-phenyl-4H-pyrazol-1-yl)-3-phenylquinazolin-4-one
• CAS: 1427523-33-8
• 化学式: C₂₃H₁₆N₄O₂
• 分子量: 380.406
• InChiKey: ISJWKONKAWPPKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  65.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(乙硫基)-3-苯基喹唑啉-4(3H)-酮 在 盐酸 、 hydrazine hydrate 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 13.0h， 生成 2-(5-oxo-3-phenyl-4,5-dihydropyrazol-1-yl)-3-phenylquinazolin-4(3H)-one
  参考文献：
  名称：

  Spectral Characterization of Novel 3-Phenyl-2-Substituted Quinazoline and Fused Quinazoline Derivatives

  摘要：

  3-phenyl-2-thioxo-quinazolin-4(3H)one 1 was utilized for the construction of some novel 2-substituted quinazolin-4(3H)one derivatives through the formation of 2-hydrazinyl quinazolinone, which was used as the key starting material for the synthesis of 2-heteryl quinazolines via the reaction with one carbon donors, -diketones and -ketoester. Infrared, H-1 NMR, and mass spectra of the synthesized compounds were discussed. Some of them showed promising anti-inflammatory activity. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

  DOI：

  10.1080/00397911.2011.642924

文献信息

• Spectral Characterization of Novel 3-Phenyl-2-Substituted Quinazoline and Fused Quinazoline Derivatives
  作者：Mahmoud R. Mahmoud、Wael S. I. Abou-Elmagd、Salwa S. Abdelwahab、El-Sayed A. Soliman

  DOI：10.1080/00397911.2011.642924

  日期：2013.6.3

  3-phenyl-2-thioxo-quinazolin-4(3H)one 1 was utilized for the construction of some novel 2-substituted quinazolin-4(3H)one derivatives through the formation of 2-hydrazinyl quinazolinone, which was used as the key starting material for the synthesis of 2-heteryl quinazolines via the reaction with one carbon donors, -diketones and -ketoester. Infrared, H-1 NMR, and mass spectra of the synthesized compounds were discussed. Some of them showed promising anti-inflammatory activity. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.