propene-1c,2,3-tricarboxylic acid triethyl ester | 5349-99-5

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: propene-1c,2,3-tricarboxylic acid triethyl ester
• 英文别名: Propen-1c,2,3-tricarbonsaeure-triaethylester；triethyl aconitate；cis-Aconitsaeure-triaethylester；triethyl (Z)-prop-1-ene-1,2,3-tricarboxylate
• CAS: 5349-99-5；68077-28-1
• 化学式: C₁₂H₁₈O₆
• 分子量: 258.271
• InChiKey: IDDWGDKSBYYEPL-CLFYSBASSA-N

物化性质

• 沸点：
  124-126 °C(Press: 0.7 Torr)
• 密度：
  1.120±0.06 g/cm3(Predicted)
• 介电常数：
  29.4（25℃）

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  propene-1c,2,3-tricarboxylic acid triethyl ester 、 水 、 甲酸乙酯 在 四氯化钛 N-甲基吗啉 、 碳酸氢钠 作用下， 以 四氢呋喃 、 四氯化碳 、 二氯甲烷 为溶剂， 生成 Diethyl-2-oxo-2H-pyran-4,5-dicarboxylat
  参考文献：
  名称：

  2- or 2,3-substituted 5,6,11,12-tetrathiotetracene and

  摘要：

  公式为 ##STR1## 的2-或2,3-取代的5,6,11,12-四硒代四苯并并[4,5]二茂烷或四硫代四苯并并[4,5]二茂烷，其中X为S或Se，R为烷氧基，羟基烷氧基，芳基氧基，环烷氧基，芳基烷氧基，-OH，-NH.sub.2，-Cl，-Br或取代氨基，Y为氢或-COR。这些化合物可以作为侧链结合到聚合物上。聚合物和这些化合物与电子受体结合形成电荷转移复合物，可以用作电导层。

  公开号：

  US04617151A1

文献信息

• Extracts of Curcuma and Methods of Use Thereof
  申请人：Alberte Randall S.

  公开号：US20100098788A1

  公开（公告）日：2010-04-22

  The present invention relates in part to turmeric extracts that are useful for treating or preventing neurodegenerative disorders. Another aspect of the invention relates in part to turmeric extracts that are useful for treating or preventing inflammatory disorders. In some embodiments, the extracts comprise at least one compound selected from the group consisting of 25 to 500 μg bamosamine, 25 to 750 μg echinaxanthol, 100 to 3,000 μg bisdemethoxycurcumin, 50 to 500 μg daphniyunnine E and 500 to 75,000 μg curcumin per 100 mg of extract. Another aspect of the invention relates to pharmaceutical compositions comprising the aforementioned extracts. Another aspect of the invention relates to methods of treating or preventing neurodegenerative disorders comprising administering to a subject in need thereof an effective amount of the aforementioned extracts or compositions. Another aspect of the invention relates to methods of making the aforementioned extracts.
• Multi-API Loading Prodrugs
  申请人：Zeidan Tarek A.

  公开号：US20120202823A1

  公开（公告）日：2012-08-09

  The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam- amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.
• BIORENEWABLE ELASTOMER GEL AND USES THEREOF
  申请人：Momentive Performance Materials Inc.

  公开号：US20220195178A1

  公开（公告）日：2022-06-23

  The present disclosure provides elastomer compositions and methods of preparing such compositions. The crosslinked polyester elastomer compositions can be formulated into various personal care formulations.
• [EN] EXTRACTS OF CURCUMA AND METHODS OF USE THEREOF<br/>[FR] EXTRAITS DE CURCUMA ET LEURS PROCÉDÉS D'UTILISATION
  申请人：HERBALSCIENCE GROUP LLC

  公开号：WO2010045577A2

  公开（公告）日：2010-04-22

  The present invention relates in part to turmeric extracts that are useful for treating or preventing neurodegenerative disorders. Another aspect of the invention relates in part to turmeric extracts that are useful for treating or preventing inflammatory disorders. In some embodiments, the extracts comprise at least one compound selected from the group consisting of 25 to 500 μg bamosamine, 25 to 750 μg echinaxanthol, 100 to 3,000 μg bisdemethoxycurcumin, 50 to 500 μg daphniyunnine E and 500 to 75,000 μg curcumin per 100 mg of extract. Another aspect of the invention relates to pharmaceutical compositions comprising the aforementioned extracts. Another aspect of the invention relates to methods of treating or preventing neurodegenerative disorders comprising administering to a subject in need thereof an effective amount of the aforementioned extracts or compositions. Another aspect of the invention relates to methods of making the aforementioned extracts.
• [EN] BIORENEWABLE ELASTOMER GEL AND USES THEREOF<br/>[FR] GEL ÉLASTOMÈRE BIORENOUVELABLE ET SES UTILISATIONS
  申请人：[en]MOMENTIVE PERFORMANCE MATERIALS INC.

  公开号：WO2022140617A1

  公开（公告）日：2022-06-30

  The present disclosure provides elastomer compositions and methods of preparing such compositions. The crosslinked polyester elastomer compositions can be formulated into various personal care products.