(Z)-1-(2,4-Dimethoxy-phenyl)-3-hydroxy-but-2-en-1-one | 126308-19-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: (Z)-1-(2,4-Dimethoxy-phenyl)-3-hydroxy-but-2-en-1-one
• CAS: 126308-19-8
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: VQFUZSFYAKYVIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.35
• 重原子数：
  16.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  55.76
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (Z)-1-(2,4-Dimethoxy-phenyl)-3-hydroxy-but-2-en-1-one 在 双氧水 作用下， 以 溶剂黄146 、 二甲基亚砜 为溶剂， 反应 4.5h， 生成 (5,8-dichloro-3-methyl-1,1-dioxo-4H-1λ6,4-benzothiazin-2-yl)-(2,4-dimethoxyphenyl)methanone
  参考文献：
  名称：

  Gupta, Archana; Saraswat, Vandana; Gupta, Sunil Kumar, Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 85, # 1-4, p. 101 - 106

  摘要：

  DOI：

文献信息

• An Efficient Synthesis and Antimicrobial Studies of Bioactive 4H-1,4-Benzothiazine and Their Sulfone Derivatives
  作者：Naveen Gautam、Yogesh Dixit、Rahul Dixit、Sudesh Kumar Gupta、Dinesh Chand Gautam

  DOI：10.1080/10426507.2012.740703

  日期：2013.8.1

  4H-1,4-benzothiazines were prepared by condensation followed by oxidative cyclization of substituted 2-aminobenzenethiols with -diketones in dimethylsulfoxide. On refluxing with 30% hydrogen peroxide in glacial acetic acid, 4H-1,4-benzothiazines yielded 4H-1,4-benzothiazine-1,1-dioxides. Structural evaluation has been done by spectral and elemental analysis. All the synthesized compounds were evaluated for their antibacterial and antifungal activity and all these have shown moderate to high activity against the test microbes. Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional text, figures and tables.
• Gupta, Vandana; Gupta, R. R., Journal fur praktische Chemie (Leipzig 1954), 1991, vol. 333, # 1, p. 153 - 156
  作者：Gupta, Vandana、Gupta, R. R.

  DOI：——

  日期：——