3-甲基-3-丁烯酸甲酯 | 25859-52-3

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 羧酸酯及其衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 3-甲基-3-丁烯酸甲酯
• 英文名称: methyl 3-methyl-3-butenoate
• 英文别名: 3-methyl-3-butenoic acid methyl ester；methyl isopropenyl acetate；3-methyl-but-3-enoic acid methyl ester；3-Methyl-but-3-ensaeure-methylester；Δ³-Isopentensaeuremethylester；β-Methylen-buttersaeuremethylester；3-Butenoic acid, 3-methyl-, methyl ester；methyl 3-methylbut-3-enoate
• CAS: 25859-52-3
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: TVTLCZHNZKWYBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-甲基-3-丁烯酸甲酯 在 platinum(IV) oxide 、 乙醚 作用下， 生成 异戊酸甲酯
  参考文献：
  名称：

  Wagner, Journal of the American Chemical Society, 1949, vol. 71, p. 3216

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基-3-丁烯-1-醇 在 jones reagent 作用下， 以 丙酮 为溶剂， 反应 1.0h， 生成 3-甲基-3-丁烯酸甲酯
  参考文献：
  名称：

  Lewis acid promoted decomposition of unsaturated .alpha.-diazo ketones. 1. An efficient approach to simple and annulated cyclopentenones

  摘要：

  DOI：

  10.1021/ja00398a021

文献信息

• NANOPARTICLES AND NANOPARTICLE COMPOSITIONS
  申请人：Zhao Yan

  公开号：US20130101516A1

  公开（公告）日：2013-04-25

  The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for example, to inhibit a virus or bacteria from binding to a host cell. The inhibition can be used in therapy for the flu, cancer, or AIDS. The CRM particles can be used, for example, to prepare metal nanoparticles or metal alloy nanoparticles, or they can be used in catalytic reactions.

  本发明提供了多价表面交联微胶粒（SCM）颗粒、交联反向微胶粒（CRM）颗粒，以及它们的制造和使用方法。例如，SCM颗粒可用于阻止病毒或细菌与宿主细胞结合。这种抑制作用可用于治疗流感、癌症或艾滋病。CRM颗粒可用于制备金属纳米颗粒或金属合金纳米颗粒，或用于催化反应。
• Dimethyl malonate/LHMDS system as a new protocol for generating methyl formate anion (−COOMe) in the condensed-phase
  作者：Valeria Di Bussolo、Salvatore Princiotto、Elisa Martinelli、Vittorio Bordoni、Paolo Crotti

  DOI：10.1016/j.tetlet.2016.02.090

  日期：2016.4

  The treatment of dimethyl malonate with LHMDS in anhydrous THF (condensed-phase) generates, in addition to the expected corresponding lithium enolate, methyl formate anion (or methoxycarbonyl anion, −COOMe) which can react with several electrophiles to give corresponding methoxycarbonyl derivatives by nucleophilic substitution reaction.

  用LHMDS在无水THF（凝聚相）丙二酸二甲酯的治疗产生，除了预期的相应的烯醇化锂，甲酸甲酯阴离子（或甲氧基羰基阴离子，- COOMe），它可以与多个亲电反应，得到通过亲核对应甲氧基羰基衍生物取代反应。
• Palladium-Catalyzed, Atmospheric Pressure Carbonylation of Allylic Halides under the Influence of Sodium Hydroxide or Alkoxides. A Facile Synthesis of β,γ-Unsaturated Acids
  作者：Tamon Okano、Nobuyuki Okabe、Jitsuo Kiji

  DOI：10.1246/bcsj.65.2589

  日期：1992.10

  The palladium-catalyzed, atmospheric-pressure carboxylation of allylic halides occurs readily in an aqueous sodium hydroxide/organic solvents two-phase system, giving β,γ-unsaturated acids. Phosphine complexes [PdCl2L2] (I, L = m-(Ph2P)C6H4SO3Na; II, L = Ph3P) or Na2[PdCl4] (III) can be used as the catalyst. Atmospheric-pressure alkoxycarbonylation is realized under the influence of a homogeneous alcoholic

  烯丙基卤化物在钯催化下的常压羧化反应在氢氧化钠水溶液/有机溶剂两相体系中很容易发生，得到 β,γ-不饱和酸。膦配合物 [PdCL2L2] (I, L = m-(Ph2P)C6H4SO3Na; II, L = Ph3P) 或 Na2[PdCl4] (III) 可用作催化剂。常压烷氧基羰基化是在均相醇钠醇溶液的影响下实现的。不含膦的钯配合物，如 [(π-烯丙基)PdCl]2 或 III，是首选的催化剂。β,γ-不饱和酯以高产率获得。
• Interrelationship between carboxyvinylketenes, methyleneketenes, vinylketenes, and hydroxyacetylenes
  作者：Curt. Wentrup、Primoz. Lorencak

  DOI：10.1021/ja00214a035

  日期：1988.3

  Carboxy(vinyl)ketenes, alkylideneketenes, and vinylketenes have been obtained selectively, sequentially, and isomerically pure for the first time by flash vacuum pyrolysis of 2,2-dimethyl-5-alkylidene-1,3-dioxane-4,6-diones (Meldrum's acid derivatives) under controlled conditions. Each of the ketenes was directly observed by IR spectroscopy and trapped with methanol or aniline. Highly unstable compounds

  通过快速真空热解 2,2-二甲基-5-亚烷基-1,3-二恶烷-4,6-二酮，首次选择性地、顺序地获得异构纯的羧基（乙烯基）烯酮、亚烷基烯酮和乙烯基烯酮（Meldrum 的酸衍生物）在受控条件下。每种乙烯酮通过红外光谱直接观察并用甲醇或苯胺捕获。高度不稳定的化合物被认为是亚烷基和乙烯基烯酮的羟基乙炔异构体，这是首次被观察到。
• METHOD FOR PRODUCING OPTICALLY ACTIVE 1,2-BIS(DIALKYLPHOSPHINO)BENZENE DERIVATIVE
  申请人：Tamura Ken

  公开号：US20130172597A1

  公开（公告）日：2013-07-04

  An industrially advantageous method for producing an optically active 1,2-bis(dialkylphosphino)benzene derivative of the present invention is provided. The method is characterized in that a phosphine-borane compound represented by the following general formula (1) is subjected to a deboronation reaction, followed by lithiation, then the reaction product is subjected to reaction with an alkyldihalogenophosphine represented by R a PX′ 2 , and thereafter the reaction product is subjected to reaction with a Grignard reagent represented by R b MgX″ to produce an optically active 1,2-bis(dialkylphosphino)benzene derivative (A). R 1 and R 2 respectively represent an alkyl group having 1 to 8 carbon atoms, and the number of carbon atoms is different between R 1 and R 2 . R a is either R 1 or R 2 and R b is the other of R 1 and R 2 . X, X′, and X″ each represent a halogen atom.

  本发明提供了一种在工业上具有优势的生产光学活性1,2-双(二烷基膦基)苯衍生物的方法。该方法的特征在于，将由下述一般式（1）表示的膦硼烷化合物进行脱硼反应，然后进行锂化反应，然后将反应产物与由RaPX′2表示的烷基二卤代膦烷发生反应，然后将反应产物与由RbMgX″表示的格氏试剂发生反应，以产生光学活性的1,2-双(二烷基膦基)苯衍生物（A）。R1和R2分别表示具有1至8个碳原子的烷基基团，且R1和R2之间的碳原子数不同。R为R1或R2中的一个，R为R1和R2中的另一个。X、X′和X″分别表示一个卤素原子。