4-(4,4,5,5-四甲基-[1,3,2]二噁硼烷-2-基)-喹啉 | 1035458-54-8

• 物质功能分类: 医药中间体 - 杂环化合物 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-(4,4,5,5-四甲基-[1,3,2]二噁硼烷-2-基)-喹啉
• 中文别名: 喹啉-4-硼酸频哪醇酯；4-喹啉硼酸频哪醇酯
• 英文名称: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline
• CAS: 1035458-54-8
• 化学式: C₁₅H₁₈BNO₂
• 分子量: 255.124
• InChiKey: LJFSIDNUMPTTAF-UHFFFAOYSA-N

物化性质

• 沸点：
  386.5±15.0 °C(Predicted)
• 密度：
  1.10

计算性质

• 辛醇/水分配系数(LogP)：
  2.53
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  2-8°C

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Quinoline-4-boronic acid pinacol ester
Synonyms: 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-quinoline

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Quinoline-4-boronic acid pinacol ester
CAS number: 1035458-54-8

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels, refrigerated.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C15H18BNO2
Molecular weight: 255.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-(4,4,5,5-四甲基-[1,3,2]二噁硼烷-2-基)-喹啉 在 N,N-二甲基乙酰胺 、 Cu(OTf)2(py)4 作用下， 以 乙腈 为溶剂， 反应 0.33h， 生成 4-[18F]fluoroquinoline
  参考文献：
  名称：

  消除杂环正电子发射断层扫描放射性配体的铜介导的 18F-氟化

  摘要：

  用氟 18 (18F) 标记的分子用于正电子发射断层扫描，以可视化、表征和测量体内的生物过程。尽管最近在将 18F 掺入芳烃方面取得了进展，但开发通用且有效的方法来标记药物发现计划所需的放射性配体仍然是一项重大任务。这个完整的描述描述了杂环正电子发射断层扫描 (PET) 放射性配体的放射合成方法，使用铜介导的 18F 氟化芳基硼试剂与 18F 氟化物作为模型反应。该方法基于一项研究，该研究检查了药物开发中常用的杂环的存在如何影响代表性芳基硼试剂的 18F-氟化效率，以及超过 50 种（杂）芳基硼酸酯的标记。这组数据允许将这种去风险策略应用于七种结构复杂的药物相关含杂环分子的成功放射合成。

  DOI：

  10.1021/jacs.7b03131
• 作为产物：
  描述：

  联硼酸频那醇酯 、 4-溴喹啉 在 C₅₄H₄₄NO₂PPdS 、 potassium acetate 作用下， 以 2-甲基四氢呋喃 为溶剂， 反应 24.0h， 生成 4-(4,4,5,5-四甲基-[1,3,2]二噁硼烷-2-基)-喹啉
  参考文献：
  名称：

  蒽光二聚体衍生的单膦配体：钯催化的偶联反应的合成应用。

  摘要：

  在这里，我们提出了一种空气稳定的二蒽基单膦配体（diAnthPhos），它可以由市售的蒽衍生物分两步制备。该配体对于钯催化的偶联反应表现出优异的效率。特别地，使用具有宽底物范围和低催化剂负载的diAnthPhos配体可以促进含杂环亲电试剂的宫浦硼化。通过对含杂芳基的底物进行一锅Miyaura硼化/ Suzuki偶联方案，进一步证明了新配体的宝贵合成效用。

  DOI：

  10.1021/acs.orglett.9b02414

文献信息

• IMIDAZOPYRIDAZINE AND IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF
  申请人：Incyte Corporation

  公开号：US20200199131A1

  公开（公告）日：2020-06-25

  Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

  揭示了公式（I）的化合物，使用这些化合物抑制ALK2活性的方法以及包含这些化合物的药物组合物。这些化合物在治疗、预防或改善与ALK2活性相关的疾病或障碍，如癌症方面具有用处。
• [EN] METALLO-BETA-LACTAMASE INHIBITORS<br/>[FR] INHIBITEURS DE MÉTALLO-BÊTA-LACTAMASES
  申请人：MERCK SHARP & DOHME

  公开号：WO2016206101A1

  公开（公告）日：2016-12-29

  The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

  本发明涉及一种属于金属β-内酰胺酶抑制剂的I式化合物，以及这种化合物的合成和将其与β-内酰胺类抗生素一起用于克服耐药性的用途。
• Spectroscopic Studies of the Chan–Lam Amination: A Mechanism-Inspired Solution to Boronic Ester Reactivity
  作者：Julien C. Vantourout、Haralampos N. Miras、Albert Isidro-Llobet、Stephen Sproules、Allan J. B. Watson

  DOI：10.1021/jacs.6b12800

  日期：2017.4.5

  of amine and organoboron reactivity issues, and the origin of competing oxidation/protodeboronation side reactions. Identification of key mechanistic events has allowed the development of a simple solution to these issues: manipulating Cu(I) → Cu(II) oxidation and exploiting three synergistic roles of boric acid has allowed the development of a general catalytic Chan-Lam amination, overcoming long-standing

  我们报告了对 Chan-Lam 胺化反应的调查。光谱学、计算模型和晶体学的结合已经确定了关键中间体的结构，并允许呈现完整的机制描述，包括非循环抑制过程、胺和有机硼反应性问题的来源，以及竞争氧化的起源/原脱硼副反应。关键机制事件的识别使得开发出解决这些问题的简单方法：操纵 Cu(I) → Cu(II) 氧化和利用硼酸的三种协同作用，开发了通用催化 Chan-Lam 胺化，克服了这种有价值的转化长期存在且未解决的胺和有机硼限制。
• Modular Dual-Tasked C–H Methylation via the Catellani Strategy
  作者：Qianwen Gao、Yong Shang、Fuzhen Song、Jinxiang Ye、Ze-Shui Liu、Lisha Li、Hong-Gang Cheng、Qianghui Zhou

  DOI：10.1021/jacs.9b07857

  日期：2019.10.9

  We report a dual-tasked methylation based on cooperative palladium/norbornene catalysis. Readily available (hetero)aryl halides (39 iodides and 4 bromides) and inexpensive MeOTs or trimethylphosphate are utilized as the substrates and meth-ylating reagent, respectively. Six types of ipso terminations can modularly couple with this ortho C-H methylation to consti-tute a versatile methylation toolbox

  我们报告了基于协同钯/降冰片烯催化的双任务甲基化。容易获得的（杂）芳基卤化物（39 个碘化物和 4 个溴化物）和廉价的 MeOT 或磷酸三甲酯分别用作底物和甲基化试剂。六种类型的 ipso 末端可以与这种邻位 CH 甲基化模块化耦合，构成一个通用的甲基化工具箱，用于制备多样化的甲基化芳烃。该工具箱具有廉价的甲基来源、出色的官能团耐受性、简单的反应程序和可扩展性。重要的是，通过切换到相应的试剂 CD3OT 或 13CH3OT，它可以顺利地扩展到同位素标记的甲基化。此外，该工具箱可用于具有完全立体保留的生物相关底物的后期修饰。
• Synthesis and Utility of Dihydropyridine Boronic Esters
  作者：Santanu Panda、Aaron Coffin、Q. Nhu Nguyen、Dean J. Tantillo、Joseph M. Ready

  DOI：10.1002/anie.201510027

  日期：2016.2.5

  When activated by an acylating agent, pyridine boronic esters react with organometallic reagents to form a dihydropyridine boronic ester. This intermediate allows access to a number of valuable substituted pyridine, dihydropyridine, and piperidine products.

  当被酰化剂活化时，吡啶硼酸酯与有机金属试剂反应形成二氢吡啶硼酸酯。该中间体允许获得许多有价值的取代吡啶，二氢吡啶和哌啶产物。