1-[(2-Fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazole-3-carboxylic acid | 1446353-53-2

分子结构分类

有机化合物 - 有机杂环化合物 - 唑类

中文名称

——

中文别名

——

英文名称

1-[(2-Fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazole-3-carboxylic acid

英文别名

——

1-[(2-Fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazole-3-carboxylic acid化学式

CAS

1446353-53-2

化学式

C₁₄H₁₀FN₃O₃

mdl

——

分子量

287.25

InChiKey

JCVATMXJJQBMCF-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

1.9
重原子数：

21
可旋转键数：

4
环数：

3.0
sp3杂化的碳原子比例：

0.07
拓扑面积：

81.2
氢给体数：

1
氢受体数：

6

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	ethyl 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboxylate	1354044-05-5	C₁₆H₁₄FN₃O₃	315.304

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	1-[(2-Fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazole-3-carbonitrile	1446353-66-7	C₁₄H₉FN₄O	268.25
——	1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide	1354044-23-7	C₁₄H₁₂FN₅O	285.281
——	2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol	1354041-90-9	C₁₇H₁₂FN₅O₂	337.313
——	2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(methylthio)pyrimidin-4-ol	1446358-68-4	C₁₈H₁₄FN₅O₂S	383.406
——	3-[5-(5-Bromo-4-chloropyrimidin-2-yl)-2-[(2-fluorophenyl)methyl]pyrazol-3-yl]-1,2-oxazole	1446358-80-0	C₁₇H₁₀BrClFN₅O	434.655
——	3-(3-(4-chloro-5-fluoropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole	1446358-48-0	C₁₇H₁₀ClF₂N₅O	373.749
——	4-Amino-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-5-ol	1446358-78-6	C₁₇H₁₃FN₆O₂	352.328
——	5-bromo-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-1H-pyrimidin-6-one	1354042-25-3	C₁₇H₁₁BrFN₅O₂	416.209
——	5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-pyrimidin-4-ol	1354041-91-0	C₁₇H₁₁F₂N₅O₂	355.303
——	3-(3-(4,6-dichloro-5-fluoropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole	1446359-43-8	C₁₇H₉Cl₂F₂N₅O	408.194
——	[5-Fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-4-yl]hydrazine	1446358-50-4	C₁₇H₁₃F₂N₇O	369.333
——	2-[1-[(2-Fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-5-methoxypyrimidin-4-amine	1354042-03-7	C₁₈H₁₅FN₆O₂	366.355
——	2-[5-Fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-4-yl]acetonitrile	1446359-60-9	C₁₉H₁₂F₂N₆O	378.341
——	4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride	1446359-92-7	C₁₇H₁₀Cl₂FN₅O₃S	454.269
——	2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(phenylthio)pyrimidin-4-ol	1446358-69-5	C₂₃H₁₆FN₅O₂S	445.477
——	5-Fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidine-4-carbonitrile	1446359-52-9	C₁₈H₁₀F₂N₆O	364.314
——	3-(3-(5-fluoro-4-methoxypyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole	1446358-49-1	C₁₈H₁₃F₂N₅O₂	369.33
——	2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(4-fluorophenylthio)pyrimidin-4-ol	1446358-64-0	C₂₃H₁₅F₂N₅O₂S	463.467
——	2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(pyridin-2-ylthio)pyrimidin-4-ol	1446358-67-3	C₂₂H₁₅FN₆O₂S	446.465
——	5-(4-chlorophenylthio)-2-( 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1 H-pyrazol-3-yl)pyrimidin-4-ol	1446358-65-1	C₂₃H₁₅ClFN₅O₂S	479.922
——	2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(4-(trifluoromethyl)phenylthio)pyrimidin-4-ol	1446358-66-2	C₂₄H₁₅F₄N₅O₂S	513.475
——	4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride	1446358-84-4	C₁₇H₁₀Cl₂FN₅O₂	406.203
——	2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-N,N-dimethyl-6-oxo-1H-pyrimidine-5-sulfonamide	1446358-71-9	C₁₉H₁₇FN₆O₄S	444.446
——	5-cyclopropylsulfonyl-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-1H-pyrimidin-6-one	1446359-36-9	C₂₀H₁₆FN₅O₄S	441.443
——	2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-5-(2,2,2-trifluoroethyl)-1H-pyrimidin-6-one	1446359-39-2	C₁₉H₁₃F₄N₅O₂	419.338
——	5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-4,6-diol	——	C₁₇H₁₁F₂N₅O₃	371.303
——	3-[5-(5-Bromo-4-phenylmethoxypyrimidin-2-yl)-2-[(2-fluorophenyl)methyl]pyrazol-3-yl]-1,2-oxazole	1446358-85-5	C₂₄H₁₇BrFN₅O₂	506.334
——	4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride	1446358-81-1	C₁₉H₁₇FN₆O₄S	444.446
——	2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-5-thiophen-3-yl-1H-pyrimidin-6-one	1446358-88-8	C₂₁H₁₄FN₅O₂S	419.439
——	2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-5-(1,3-oxazol-2-yl)-1H-pyrimidin-6-one	1446358-94-6	C₂₀H₁₃FN₆O₃	404.36
——	2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-5-(1,3-thiazol-2-yl)-1H-pyrimidin-6-one	1446358-92-4	C₂₀H₁₃FN₆O₂S	420.427
——	[4-Amino-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]pyrimidin-5-yl] 1-methylcyclopropane-1-carboxylate	1446358-79-7	C₂₂H₁₉FN₆O₃	434.43
——	2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-5-pyridin-2-yl-1H-pyrimidin-6-one	1446358-90-2	C₂₂H₁₅FN₆O₂	414.399
——	6-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-5-(trifluoromethyl)pyrimidin-4(3H)-one	1446358-51-5	C₁₈H₁₀F₅N₅O₂	423.302
——	2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-5-morpholin-4-ylsulfonyl-1H-pyrimidin-6-one	1354042-94-6	C₂₁H₁₉FN₆O₅S	486.483
——	N-benzyl-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-N-methyl-6-oxo-1H-pyrimidine-5-sulfonamide	1446358-73-1	C₂₅H₂₁FN₆O₄S	520.544
——	2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-5-pyrrolidin-1-ylsulfonyl-1H-pyrimidin-6-one	1446358-72-0	C₂₁H₁₉FN₆O₄S	470.484
——	3-[5-[5-Bromo-4-[(4-methoxyphenyl)methoxy]pyrimidin-2-yl]-2-[(2-fluorophenyl)methyl]pyrazol-3-yl]-1,2-oxazole	1446358-86-6	C₂₅H₁₉BrFN₅O₃	536.36
——	3-(3-(4-chloro-5-fluoro-6-methoxypyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole	1446359-44-9	C₁₈H₁₂ClF₂N₅O₂	403.775
——	N-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-N-methyl-6-oxo-1H-pyrimidine-5-sulfonamide	1446358-74-2	C₂₁H₁₉FN₆O₄S	470.484
——	2-[1-[(2-Fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)pyrazol-3-yl]-N-methyl-6-oxo-N-phenyl-1H-pyrimidine-5-sulfonamide	1446358-70-8	C₂₄H₁₉FN₆O₄S	506.517
——	4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride	1446358-82-2	C₂₁H₁₉FN₆O₄S	470.484
——	4-chloro-2