methyl (2E)-3-(6-(6-amino-9-(3-(isopropylamino)propyl)-9H-purin-8-ylthio)benzo[d][1,3]dioxol-5-yl)acrylate | 1428730-66-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: methyl (2E)-3-(6-(6-amino-9-(3-(isopropylamino)propyl)-9H-purin-8-ylthio)benzo[d][1,3]dioxol-5-yl)acrylate
• CAS: 1428730-66-8
• 化学式: C₂₂H₂₆N₆O₄S
• 分子量: 470.552
• InChiKey: LDFQYWAQPKGWMN-AATRIKPKSA-N

反应信息

• 作为产物：
  描述：

  6-氨基-8-[(6-碘-1,3-苯并二茂-5-基)硫基]-N-异丙基-9H-嘌呤-9-丙胺 、 丙烯酸甲酯（MA） 在 N,N-二异丙基乙胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 24.0h， 以35%的产率得到methyl (2E)-3-(6-(6-amino-9-(3-(isopropylamino)propyl)-9H-purin-8-ylthio)benzo[d][1,3]dioxol-5-yl)acrylate
  参考文献：
  名称：

  Preparation of a Diverse Purine-Scaffold Library via One-Step Palladium Catalyzed Cross-Coupling

  摘要：

  In our ongoing efforts to prepare Hsp90 inhibitors, various cross-coupling reactions (Suzuki, Stille, Heck, and Sonogashira) were used to construct a diverse library of substituted purines in a single step from PU-H71 (1). We show that these reactions, particularly Suzuki coupling, are highly efficient, do not require protection of the pendant amine, and due to the wide variety of commercially available substrates, allow for the rapid development of a diverse purine library. The products derived from these reactions will enable us to explore the chemical space occupied by the key 6'-iodine of PU-H71 through molecules with diverse physical and chemical properties with the potential to be useful for diseases in which Hsp90 is implicated.

  DOI：

  10.3987/com-12-12613