ethyl 2-(2-bromo-4-methoxyphenyl)-2,3-dihydro-3,4-dihydroxy-6-methoxybenzofuran-3-carboxylate | 1312466-11-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: ethyl 2-(2-bromo-4-methoxyphenyl)-2,3-dihydro-3,4-dihydroxy-6-methoxybenzofuran-3-carboxylate
• CAS: 1312466-11-7
• 化学式: C₁₉H₁₉BrO₇
• 分子量: 439.26
• InChiKey: XXYWSLMVIITRRL-PKOBYXMFSA-N

反应信息

• 作为产物：
  描述：

  ethyl 2-(2-bromo-4-methoxyphenyl)-2,3,4,5,6,7-hexahydro-3-hydroxy-6,6-dimethoxy-4-oxobenzofuran-3-carboxylate 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 1.17h， 生成 ethyl 2-(2-bromo-4-methoxyphenyl)-2,3-dihydro-3,4-dihydroxy-6-methoxybenzofuran-3-carboxylate 、 ethyl 2-(2-bromo-4-methoxyphenyl)-2,3-dihydro-3,4-dihydroxy-6-methoxybenzofuran-3-carboxylate
  参考文献：
  名称：

  Asymmetric Total Syntheses of (−)-Variabilin and (−)-Glycinol

  摘要：

  Total syntheses of (-)-variabilin and (-)-glycinol have been accomplished, using the catalytic, asymmetric "Interrupted" Feist-Benary reaction (IFB) as the key transformation to introduce both stereogenic centers. A monoquinidine pyrimidinyl ether catalyst affords the IFB products In over 90% ee in both cases. Other key steps include an intramolecular Buohwald-Hartwig coupling and a nickel-catalyzed aryl tosylate reduction.

  DOI：

  10.1021/ol201332u