4-[3-(4-methoxyphenyl)-7-methyl-2H-chromen-2-yl]phenol | 189290-14-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 4-[3-(4-methoxyphenyl)-7-methyl-2H-chromen-2-yl]phenol
• CAS: 189290-14-0
• 化学式: C₂₃H₂₀O₃
• 分子量: 344.41
• InChiKey: NVNOPWSSEIIRTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2-氯乙基)哌啶盐酸盐 、 4-[3-(4-methoxyphenyl)-7-methyl-2H-chromen-2-yl]phenol 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 1-[2-[4-[3-(4-methoxyphenyl)-7-methyl-2H-chromen-2-yl]phenoxy]ethyl]piperidine
  参考文献：
  名称：

  Synthesis and post-coital contraceptive activity of a new series of substituted 2,3-diaryl-2H-1-benzopyrans

  摘要：

  A series of substituted 2,3-diaryl-2H-1-benzopyrans have been synthesized and screened for their post-coital contraceptive activity in rats. Most of the compounds showed 100% inhibition in a single day schedule at a dose level of 1.0 mg/kg. Compound 32 was found to be the most active with a minimum effective dose (MED) of 0.2 mg/kg in single day testing. Further, it also showed high antiestrogenic activity and is devoid of any agonistic activity.

  DOI：

  10.1016/s0223-5234(97)87540-x
• 作为产物：
  描述：

  1-(2-Hydroxy-4-methyl-phenyl)-2-(4-methoxy-phenyl)-ethanone 在 哌啶 、 sodium tetrahydroborate 作用下， 以 乙醇 、 苯 为溶剂， 生成 4-[3-(4-methoxyphenyl)-7-methyl-2H-chromen-2-yl]phenol
  参考文献：
  名称：

  Synthesis and post-coital contraceptive activity of a new series of substituted 2,3-diaryl-2H-1-benzopyrans

  摘要：

  A series of substituted 2,3-diaryl-2H-1-benzopyrans have been synthesized and screened for their post-coital contraceptive activity in rats. Most of the compounds showed 100% inhibition in a single day schedule at a dose level of 1.0 mg/kg. Compound 32 was found to be the most active with a minimum effective dose (MED) of 0.2 mg/kg in single day testing. Further, it also showed high antiestrogenic activity and is devoid of any agonistic activity.

  DOI：

  10.1016/s0223-5234(97)87540-x

文献信息

• Synthesis and post-coital contraceptive activity of a new series of substituted 2,3-diaryl-2H-1-benzopyrans
  作者：K Hajela、RS Kapil

  DOI：10.1016/s0223-5234(97)87540-x

  日期：1997.1

  A series of substituted 2,3-diaryl-2H-1-benzopyrans have been synthesized and screened for their post-coital contraceptive activity in rats. Most of the compounds showed 100% inhibition in a single day schedule at a dose level of 1.0 mg/kg. Compound 32 was found to be the most active with a minimum effective dose (MED) of 0.2 mg/kg in single day testing. Further, it also showed high antiestrogenic activity and is devoid of any agonistic activity.