美商陆酸 | 54928-05-1

• 物质功能分类: 生物化工
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 美商陆酸
• 英文名称: phytolaccagenic acid
• 英文别名: (2S,4aR,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-hydroxy-9-(hydroxymethyl)-2-methoxycarbonyl-2,6a,6b,9,12a-pentamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
• CAS: 54928-05-1
• 化学式: C₃₁H₄₈O₆
• 分子量: 516.719
• InChiKey: YAGYBNOEVSEGSL-HGDAMUQJSA-N

物化性质

• 熔点：
  295～299℃
• 沸点：
  623.4±55.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  美商陆酸 在 吡啶 作用下， 以 乙醚 为溶剂， 反应 4.0h， 生成 (2S,4aR,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-10-Acetoxy-9-acetoxymethyl-2,6a,6b,9,12a-pentamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-2,4a-dicarboxylic acid dimethyl ester
  参考文献：
  名称：

  来自商陆的齐墩果烷衍生物的其他三萜类化合物和 13C NMR 光谱

  摘要：

  摘要 除了五种已知的三萜类化合物，即acinosolic acid、phytolaccagenin、phytolaccagenic acid、esculentic acid 和 jaligonic acid，三种新的齐墩果烷衍生物，命名为phytolaccagenin A、acinosolic acid A 和acinosolic acid B，已从脱脂浆果中分离并表征。商陆。新化合物已被鉴定为 3β-acetoxy-3β-methyloleanate-12-en-2β,23α-diol-28β-oic acid, 3β-acetoxy-28β-methyloleanate-12-en-2β-ol-30β-oic acid和 2β-acetoxy-28β-methyloleanate-12-en-3β-ol-30β-oic 酸，分别。

  DOI：

  10.1016/0031-9422(84)83036-8
• 作为产物：
  描述：

  3-O-β-D-glucopyranosylphytolaccagenic acid 28-O-β-D-glucopyranosyl ester 、 水 、 盐酸 生成 美商陆酸
  参考文献：
  名称：

  BANDARA, B. M. RATNAYAKE;JAYASINGHE, LALITH;KARUNARATNE, VERANJA;WANNIGAM+, PHYTOCHEMISTRY, 28,(1989) N0, C. 2783-2785

  摘要：

  DOI：

文献信息

• Polynucleotide binding complexes comprising sterols and saponin
  申请人：Nordic Vaccine Technology A/S

  公开号：EP2011517A1

  公开（公告）日：2009-01-07

  The present invention pertains to complexes comprising sterols and saponins. The complexes are capable of binding a genetic determinant including a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contacting group and/or a targeting ligand, and/or a saccharide moiety. The complexes may further comprise an immunogenic determinant and/or an antigenic determinant and/or a medicament and/or a diagnostic compound. The complexes may in even further embodiments be encapsulated by an encapsulation agent including a biodegradable microsphere. The present invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and/or surgery, methods of cosmetic treatment, and diagnostic methods practised on the human or animal body.

  本发明涉及由甾醇和皂甙组成的复合物。这些复合物能够结合包括多核苷酸在内的遗传决定因子。复合物可进一步包含亲脂分子，可选择包含接触基团和/或靶向配体的亲脂分子和/或糖分子。复合物可进一步包括免疫原决定簇和/或抗原决定簇和/或药物和/或诊断化合物。在更进一步的实施方案中，复合物可被包括生物可降解微球在内的封装剂封装。本发明还涉及通过治疗和/或手术对个体进行治疗的药物组合物和方法、美容治疗方法以及对人体或动物体进行诊断的方法。
• Preparation of novel gels for the purification of non-polar extractives
  申请人：Her Majesty in Right of Canada as Represented by the Minister of Agriculture and Agri-Food Canada

  公开号：US20030150805A1

  公开（公告）日：2003-08-14

  A process is described for the preparation f electrostatically-linked, aliphatic- or alicyclic-substituted anionic or cationic polysaccharide gels from readily available macroporous ionic polysaccharide chromatographic media, such as diethylaminoethyl (DEAE), quaternary aminoethyl (QAE) and sulfopropyl (SP) substituted polysaccharide gels. These novel gels are used for the isolation, recovery and purification of non-polar extractives using one or more extracting solvents from the group of lower alcohols, ketones, and water. The non-polar extractives may be alk(n)lyresorcinols, steroid, triterpenoid, cardiac glycosides and saponins, steryl ferulates and other phenolic acid conjugates, flavonoids, lipids, alcohol-soluble antimicrobials, prolamines or other alcohol-soluble proteolipid complexes.

  本发明描述了一种从现成的大孔离子多糖色谱介质（如二乙基氨基乙基（DEAE）、季铵乙基（QAE）和磺丙基（SP）取代的多糖凝胶）制备静电连接的脂肪族或脂环族取代的阴离子或阳离子多糖凝胶的工艺。这些新型凝胶可用于分离、回收和纯化非极性萃取物，使用的萃取溶剂可以是低级醇、酮和水中的一种或多种。非极性萃取物可以是烷基（n）赖氨酸间苯二酚、甾体、三萜类、强心苷和皂苷、甾基阿魏酸和其他酚酸共轭物、黄酮类、脂类、醇溶性抗菌剂、丙胺或其他醇溶性蛋白脂复合物。
• Method of protecting plants from bacterial and fungal diseases
  申请人：Dutcheshen M. Joseph

  公开号：US20050261129A1

  公开（公告）日：2005-11-24

  Improved methods and compositions for protecting plants or seeds from plant diseases are provided. The compositions comprise (and preferably consist essentially of) saponin, such as triterpene type saponins extracted from quinoa or quillaja. Compositions according to the invention may comprise (or consist essentially of) a quantity of a sapogenin compound, preferably a sapogenins selected from the group consisting of oleanolic acid, hederagenin, phytolaccinic acid, and quillaic acid. The methods comprise contacting the portion of the plant (e.g., foliage, shoot, etc.) to be treated with a disease-inhibiting or protective amount of the composition. The compositions can also be used to treat plant seeds or tubers prior to planting thereof, as well as soil adjacent a growing plant. The inventive compositions are particularly useful for the treatment, control and/or prevention of bacterial diseases. The saponins of the invention can be applied as liquids or dry particulates, and are especially suited for the treatment of tomato and potato plants and their respective seeds.

  提供了保护植物或种子免受植物病害的改进方法和组合物。这些组合物包括（最好基本上包括）皂苷，例如从藜麦或藜芦中提取的三萜类皂苷。根据本发明的组合物可以包括（或主要包括）一定量的苷元化合物，最好是选自齐墩果酸、赤皂苷、植物鞣酸和紫苏酸组成的组的苷元。这些方法包括将待处理的植物部分（如叶片、嫩枝等）与一定量的抑制病害或保护性组合物接触。本发明的组合物还可用于植物种子或块茎种植前的处理，以及生长植物附近土壤的处理。本发明的组合物尤其适用于治疗、控制和/或预防细菌性疾病。本发明的皂苷可以液体或干燥颗粒的形式使用，尤其适用于番茄和马铃薯植物及其种子的处理。
• THE PREPARATION OF NOVEL GELS FOR THE PURIFICATION OF NON-POLAR EXTRACTIVES
  申请人：Her Majesty in Right of Canada, represented by The Minister of Agriculture and Agri-Food Canada

  公开号：EP1047496A1

  公开（公告）日：2000-11-02
• PROCESS FOR RECOVERY AND PURIFICATION OF SAPONINS AND SAPOGENINS FROM QUINOA (CHENOPODIUM QUINOA)
  申请人：Her Majesty The Queen in Right of Canada, as represented by The Minister of Agriculture and Agri-Food Canada

  公开号：EP1071441A1

  公开（公告）日：2001-01-31