Adenosine-5'-carboxylic acid | 3415-09-6

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: Adenosine-5'-carboxylic acid
• 英文别名: 5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxylic acid
• CAS: 3415-09-6
• 化学式: C₁₀H₁₁N₅O₅
• 分子量: 281.23
• InChiKey: IBYWUFHJUDTSOC-UHFFFAOYSA-N

物化性质

• 熔点：
  198-200 °C
• 沸点：
  756.3±70.0 °C(Predicted)
• 密度：
  2.24±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于二甲基亚砜、水

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  157
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• WGK Germany：
  3
• 海关编码：
  2934999090
• 危险性防范说明：
  P264,P280,P302+P352,P337+P313,P305+P351+P338,P362+P364,P332+P313
• 危险性描述：
  H315,H319
• 储存条件：
  存储于室温环境，置于惰性气体中并避免光照。

文献信息

• Combination therapies for treating methylthioadenosine phosphorylase deficient cells
  申请人：——

  公开号：US20040043959A1

  公开（公告）日：2004-03-04

  The present invention is directed to combination therapies for treating cell proliferative disorders associated with methylthioadenosine phosphorylase (MTAP) deficient cells in a mammal. The combination therapies selectively kill MTAP-deficient cells by administering an inhibitor of de novo inosinate synthesis and administering an anti-toxicity agent, wherein the inhibitors of de novo inosinate synthesis are inhibitors of glycinamide ribonucleotide formyltransferase (“GARFT”) and/or aminoinidazolecarboximide ribonucleotide formyltransferase (“AICARFT”), and the anti-toxicity agent is an MTAP substrate (e.g. methylthioadenosine or “MTA”), a precursor of MTA, an analog of an MTA precursor or a prodrug of an MTAP substrate.

  本发明涉及用于治疗哺乳动物中与甲基硫腺苷磷酸化酶（MTAP）缺乏细胞相关的细胞增殖性疾病的联合疗法。该联合疗法通过给予新生核苷酸合成抑制剂和给予抗毒性剂，选择性地杀死MTAP缺乏细胞，其中，新生核苷酸合成抑制剂是甘氨酰核苷酸甲酰转移酶（“GARFT”）和/或氨基咪唑羧酰核苷酸甲酰转移酶（“AICARFT”）的抑制剂，抗毒性剂是MTAP底物（例如，甲基硫腺苷或“MTA”），MTA的前体，MTA前体的类似物或MTAP底物的前药。
• PHOTOLUMINESCENT MOLECULAR COMPLEX AND METHOD FOR DETERMINING OF THE CONCENTRATION OF SAID MOLECULAR COMPLEX
  申请人：Uri Asko

  公开号：US20140057284A1

  公开（公告）日：2014-02-27

  The invention concerns novel molecular complexes with photoluminescent probes whose specific association with purine-binding proteins leads to increased emission of long lifetime luminescence, and the application of the probes for monitoring activity of protein kinases (PKs) and other purine-binding proteins, screening of compounds as inhibitors of PKs and characterization of inhibitors targeted to the kinase, and methods of manufacturing of such probes. The invention concerns also the use of the improved method for monitoring activity of protein kinases in living cells, characterization of inhibitors of protein kinases, analysis of protein kinase-based disease biomarkers and other tasks of biological and medical importance.

  本发明涉及新型分子复合物，其中包含光致发光探针，其与嘌呤结合蛋白的特定结合导致发射长寿命荧光的增加，以及探针在监测蛋白激酶（PKs）和其他嘌呤结合蛋白的活性、筛选PKs抑制剂化合物和定向于激酶的抑制剂的表征以及制造这种探针的方法。本发明还涉及改进的方法用于监测活细胞中的蛋白激酶活性，表征蛋白激酶抑制剂，分析基于蛋白激酶的疾病生物标志物和其他生物和医学重要任务的使用。
• A photoluminescent probe
  申请人：University of Tartu

  公开号：EP2482072A1

  公开（公告）日：2012-08-01

  The invention relates to organic long lifetime photoluminescent probes that contain no metal complexes and whose specific association with purine-binding proteins leads to increased emission of long wavelength luminescence with long lifetime (in microsecond region). This enables the time-gated discrimination of the signal over fluorescence present in the biological samples, either autofluorescence of cells or emission from other fluorophores. The invention concerns also the use of the improved method for monitoring activity of protein kinases in living cells, characterization of inhibitors of protein kinases, analysis of protein kinase-based disease biomarkers and other tasks of biological and medical importance.

  本发明涉及不含金属络合物的有机长寿命光致发光探针，其与嘌呤结合蛋白的特异性结合可增加长寿命（微秒级）长波长发光的发射。这样就能对生物样品中存在的荧光（细胞的自发荧光或其他荧光团发出的荧光）进行时间分辨。本发明还涉及将改进的方法用于监测活细胞中蛋白激酶的活性、表征蛋白激酶抑制剂、分析基于蛋白激酶的疾病生物标志物以及其他具有生物学和医学重要性的任务。
• Methods for modulating taste receptors
  申请人：MARS, INCORPORATED

  公开号：US11185100B2

  公开（公告）日：2021-11-30

  Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, and/or enhances the activity of the umami receptor. Such compounds can be used in flavor compositions to enhance the umami taste and/or palatability of food products.

  本文描述了存在于鲜味受体结构域中的氨基酸，其中氨基酸与至少一种核苷酸衍生物和/或至少一种跨膜化合物相互作用，从而增强、调节、增加和/或提高鲜味受体的活性。此类化合物可用于调味组合物，以增强食品的鲜味和/或适口性。
• A PHOTOLUMINESCENT PROBE
  申请人：University of Tartu

  公开号：EP2482072B1

  公开（公告）日：2016-07-06