(+)-Totarol | 411239-21-9

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (+)-Totarol
• 英文别名: 4b,8,8-trimethyl-1-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthren-2-ol
• CAS: 411239-21-9
• 化学式: C₂₀H₃₀O
• 分子量: 286.5
• InChiKey: ZRVDANDJSTYELM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Novel lipophilic fluorescent dyes and a process for their production
  申请人：RADIANT COLOR N.V.

  公开号：EP2166040A1

  公开（公告）日：2010-03-24

  The present invention provides lipophilic fluorescent chromophores which are suitable for use as tracer dye in lipophilic liquids, for example in leak detection applications. The lipophilic fluorescent chromophores have been provided in different shades like green, greenish-yellow, yellow, orange and red. The use of fluorescent dyes is preferred as they have a much better visibility than their conventional countertypes, especially when exposed to ultraviolet light or also better to broad spectrum lamps. The presented chromophores contains at least one substituent at least part of which extends from the planar aromatic chromophore part, the ratio of the number of atoms (no H-atoms) in the molecule forming part of non planar substituents to the number of atoms (no H-atoms) forming part of the planar aromatic chromophore structure being at least 0.75.

  本发明提供了适用于在亲脂性液体中用作示踪染料的亲脂性荧光色素，例如在泄漏检测应用中。这些亲脂性荧光色素具有不同的颜色，如绿色、绿黄色、黄色、橙色和红色。荧光染料的使用更受青睐，因为它们在紫外光下或广谱灯光下的可见性比传统对应物要好得多。所述的色素包含至少一个取代基，其中至少部分从平面芳香色素部分延伸出来，分子中非平面取代基的原子数（不包括氢原子）与平面芳香色素结构中的原子数（不包括氢原子）的比率至少为0.75。
• METHODS, COMPOSITIONS AND KITS FOR PROMOTING MOTOR NEURON SURVIVAL AND TREATING AND DIAGNOSING NEURODEGENERATIVE DISORDERS
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20160082015A1

  公开（公告）日：2016-03-24

  Methods, compositions, and kits for promoting motor neuron survival and for treatment and diagnosis of neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS) and Spinal muscular atrophy (SMA) are described herein.

  本文描述了促进运动神经元存活以及治疗和诊断神经退行性疾病，如肌萎缩侧索硬化症（ALS）和脊髓性肌萎缩症（SMA）的方法、组合物和试剂盒。
• Method for the preperation of (+)-totarol
  申请人：Cognis IP Management GmbH

  公开号：EP2143703A1

  公开（公告）日：2010-01-13

  The present invention pertains to a simple route to prepare (+)-Totarol from (-)-Sclareol. As intermediate a compound according to formula (I) is used. Compound (I) is reacted with potassium-tert-butylate, suspended in tert-butanol under a oxygen free atmosphere at the boiling temperature of the mixture; then isopropyl iodide is added and the reaction product (II) is separated; As second step the compound (II) is suspended in acetonitrile and then reacted in an oxygen free atmosphere with a blend of LiBr and CuBr2, heated to reflux to form (+)-Totarol.

  本发明涉及一种从 (-)-Sclareol 制备 (+)-Totarol 的简单方法。作为中间体使用的是符合式 (I) 的化合物。 在混合物的沸腾温度下，在无氧气氛中将化合物（I）与悬浮在叔丁醇中的叔丁酸钾反应，然后加入碘化异丙酯，分离反应产物（II）； 第二步，将化合物（II）悬浮在乙腈中，然后在无氧环境下与 LiBr 和 CuBr2 的混合物反应，加热至回流，生成 (+)-Totarol 。
• Method for the preparation of (+)-totarol
  申请人：Cognis IP Management GmbH

  公开号：EP2143703B1

  公开（公告）日：2011-05-18
• MITTEL ENTHALTEND MIKROPARTIKEL ZUR REINIGUNG UND ZUM SCHUTZ VON TECHNISCHEN OBERFLÄCHEN
  申请人：Aimecs GmbH

  公开号：EP3032949B1

  公开（公告）日：2021-03-03

表征谱图