(1S,3aS,7aR)-1-hydroxymethyl-3a-hydroxy-7a-methyl-5-perhydroindenone | 178379-39-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,3aS,7aR)-1-hydroxymethyl-3a-hydroxy-7a-methyl-5-perhydroindenone
• 英文别名: (1S,3aS,7aR)-3a-hydroxy-1-(hydroxymethyl)-7a-methyl-1,2,3,4,6,7-hexahydroinden-5-one
• CAS: 178379-39-0
• 化学式: C₁₁H₁₈O₃
• 分子量: 198.262
• InChiKey: MPLOQOGFRRCHCT-IEBDPFPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1S,3aS,7aR)-1-hydroxymethyl-3a-hydroxy-7a-methyl-5-perhydroindenone 在 镍 、 2-碘酰基苯甲酸 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 、 环己烷 、 水 、 二甲基亚砜 为溶剂， 反应 5.5h， 生成 (1S,3aS,5S,7aR)-3a-hydroxy-5-phenyl-7a-methylperhydroindene-1-carboxaldehyde
  参考文献：
  名称：

  Synthesis and Inotropic Activity of 1-(O-Aminoalkyloximes) of Perhydroindene Derivatives as Simplified Digitalis-like Compounds Acting on the Na⁺,K⁺-ATPase

  摘要：

  A series of 5-substituted (3aS,7aR)-7a-methylperhydroinden-3a-ol derivatives bearing a 1(S)(omega-aminoalkoxy)iminoalkyl or -alkenyl substituent was synthesized, starting from the Hajos-Parrish ketol 47, as simplified analogues of very potent 17beta-aminoalkyloximes with digitalis skeleton, previously reported. The target compounds were evaluated in vitro for displacement of the specific [H-3]ouabain binding from the dog kidney Na+,K+-ATPase receptor. Some of them revealed IC50 values in the micromolar range. The most active compounds possess a cyclohexyl group in the 5(S) position and in position 1(S) the same aminoalkyloxime groups already reported for the digitoxigenin-like series in position 17beta. Although the ring conformation of these derivatives was comparable to that of uzarigenin, the binding affinities of the most active ones were 4/8-fold lower in comparison to that standard, Three compounds among those with the highest affinities were assayed in vitro for their inotropic activity on an electrically driven guinea pig left atrium and were found to be less potent than both digoxin, the most widely used inotropic agent, and the corresponding digitalis 17beta-aminoalkyloximes.

  DOI：

  10.1021/jm011001k
• 作为产物：
  描述：

  (+)-六氢-3a-羟基-7a-甲基-1H-茚-1,5(6H)-二酮 在 硼烷 、 potassium tert-butylate 、 草酸 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 水 、 乙腈 、 叔丁醇 为溶剂， 反应 51.0h， 生成 (1S,3aS,7aR)-1-hydroxymethyl-3a-hydroxy-7a-methyl-5-perhydroindenone
  参考文献：
  名称：

  Synthesis and Inotropic Activity of 1-(O-Aminoalkyloximes) of Perhydroindene Derivatives as Simplified Digitalis-like Compounds Acting on the Na⁺,K⁺-ATPase

  摘要：

  A series of 5-substituted (3aS,7aR)-7a-methylperhydroinden-3a-ol derivatives bearing a 1(S)(omega-aminoalkoxy)iminoalkyl or -alkenyl substituent was synthesized, starting from the Hajos-Parrish ketol 47, as simplified analogues of very potent 17beta-aminoalkyloximes with digitalis skeleton, previously reported. The target compounds were evaluated in vitro for displacement of the specific [H-3]ouabain binding from the dog kidney Na+,K+-ATPase receptor. Some of them revealed IC50 values in the micromolar range. The most active compounds possess a cyclohexyl group in the 5(S) position and in position 1(S) the same aminoalkyloxime groups already reported for the digitoxigenin-like series in position 17beta. Although the ring conformation of these derivatives was comparable to that of uzarigenin, the binding affinities of the most active ones were 4/8-fold lower in comparison to that standard, Three compounds among those with the highest affinities were assayed in vitro for their inotropic activity on an electrically driven guinea pig left atrium and were found to be less potent than both digoxin, the most widely used inotropic agent, and the corresponding digitalis 17beta-aminoalkyloximes.

  DOI：

  10.1021/jm011001k

文献信息

• 1,5-disubstituted 7A-methylperhydroinden-3A-ol derivatives, useful in
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：US05705531A1

  公开（公告）日：1998-01-06

  1,5-Disubstituted 5a-methylperhydroinden-3a-ol derivatives of formula (I): ##STR1## where either the symbol - - - - represents a single bond, the group A is in cis configuration with respect to the 3a-hydroxy, 7a-methyl and 1-L groups, and A is (CH.dbd.CH).sub.m (CH.sub.2).sub.n OR, (CH.dbd.CH).sub.m (CH.sub.2).sub.n NR.sup.1 R.sup.2, (CH.dbd.CH).sub.m (CH.sub.2).sub.p B, OH, O(CH.sub.2).sub.q OR, O(CH.sub.2).sub.q NR.sup.1 R.sup.2 or O(CH.sub.2).sub.r B; q is an integer from 2 to 5; r is an integer from 1 to 2; or the symbol - - - - represents a double bond, A is oxygen, CH(CH.dbd.CH).sub.s (CH.sub.2).sub.n OR, CH(CH.dbd.CH).sub.s (CH.sub.2).sub.n NR.sup.1 R.sup.2 or CH(CH.dbd.CH).sub.s (CH.sub.2).sub.p B; and L is \x9bCH.dbd.C(R.sup.3)!.sub.s CH.dbd.NR.sup.4 or \x9bCH.dbd.C(R.sup.3)!.sub.s CH.sub.2 NHR.sup.4, in the E configuration, are useful for treating cardiovascular disorders such as heart failure and hypertension.

  式(I)的1,5-二取代5a-甲基过氢化吲哚-3a-醇衍生物：##STR1## 其中符号- - - -表示单键，基团A与3a-羟基、7a-甲基和1-L基团的顺式构型相关，A为(CH.dbd.CH).sub.m (CH.sub.2).sub.n或(CH.dbd.CH).sub.m (CH.sub.2).sub.n NR.sup.1 R.sup.2，(CH.dbd.CH).sub.m (CH.sub.2).sub.p B，OH，O(CH.sub.2).sub.q或O(CH.sub.2).sub.q NR.sup.1 R.sup.2或O(CH.sub.2).sub.r B; q为2至5的整数; r为1至2的整数; 或符号- - - -表示双键，A为氧、CH(CH.dbd.CH).sub.s (CH.sub.2).sub.n或CH(CH.dbd.CH).sub.s (CH.sub.2).sub.n NR.sup.1 R.sup.2或CH(CH.dbd.CH).sub.s (CH.sub.2).sub.p B; L为\x9bCH.dbd.C(R.sup.3)!.sub.s CH.dbd.NR.sup.4或\x9bCH.dbd.C(R.sup.3)!.sub.s CH.sub.2 NHR.sup.4，以E构型存在，可用于治疗心血管疾病，如心力衰竭和高血压。
• Medarde, Manuel; Caballero, Esther; Tome, Fernando, Anales de Quimica, 1995, vol. 91, # 1-2, p. 89 - 94
  作者：Medarde, Manuel、Caballero, Esther、Tome, Fernando、Melero, Concepcion P.、Boya, Melchor、Feliciano, Arturo San

  DOI：——

  日期：——
• 1,5-Disubstituted 7a-methylperhydroinden-3a-ol derivatives, active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0710646B1

  公开（公告）日：1998-12-16
• US5705531A
  申请人：——

  公开号：US5705531A

  公开（公告）日：1998-01-06
• Synthesis and Inotropic Activity of 1-(<i>O</i>-Aminoalkyloximes) of Perhydroindene Derivatives as Simplified Digitalis-like Compounds Acting on the Na⁺,K⁺-ATPase
  作者：Alberto Cerri、Nicoletta Almirante、Paolo Barassi、Alessandra Benicchio、Sergio De Munari、Giuseppe Marazzi、Isabella Molinari、Fulvio Serra、Piero Melloni

  DOI：10.1021/jm011001k

  日期：2002.1.1

  A series of 5-substituted (3aS,7aR)-7a-methylperhydroinden-3a-ol derivatives bearing a 1(S)(omega-aminoalkoxy)iminoalkyl or -alkenyl substituent was synthesized, starting from the Hajos-Parrish ketol 47, as simplified analogues of very potent 17beta-aminoalkyloximes with digitalis skeleton, previously reported. The target compounds were evaluated in vitro for displacement of the specific [H-3]ouabain binding from the dog kidney Na+,K+-ATPase receptor. Some of them revealed IC50 values in the micromolar range. The most active compounds possess a cyclohexyl group in the 5(S) position and in position 1(S) the same aminoalkyloxime groups already reported for the digitoxigenin-like series in position 17beta. Although the ring conformation of these derivatives was comparable to that of uzarigenin, the binding affinities of the most active ones were 4/8-fold lower in comparison to that standard, Three compounds among those with the highest affinities were assayed in vitro for their inotropic activity on an electrically driven guinea pig left atrium and were found to be less potent than both digoxin, the most widely used inotropic agent, and the corresponding digitalis 17beta-aminoalkyloximes.