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(2R,3R)-3,4-diethylmethylenedioxy-2-methyl-butan-1-ol | 153185-63-8

中文名称
——
中文别名
——
英文名称
(2R,3R)-3,4-diethylmethylenedioxy-2-methyl-butan-1-ol
英文别名
(2R)-2-[(4R)-2,2-diethyl-1,3-dioxolan-4-yl]propan-1-ol
(2R,3R)-3,4-diethylmethylenedioxy-2-methyl-butan-1-ol化学式
CAS
153185-63-8
化学式
C10H20O3
mdl
——
分子量
188.267
InChiKey
JAUYUYAMTPNHDO-BDAKNGLRSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    253.0±15.0 °C(Predicted)
  • 密度:
    0.970±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    1.6
  • 重原子数:
    13
  • 可旋转键数:
    4
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    1.0
  • 拓扑面积:
    38.7
  • 氢给体数:
    1
  • 氢受体数:
    3

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Total synthesis of (+)-tautomycin
    作者:Satoshi Shimizu、Sei-ichi Nakamura、Masahisa Nakada、Masakatsu Shibasaki
    DOI:10.1016/0040-4020(96)00811-3
    日期:1996.10
    A convergent stereocontrolled total synthesis of (+)-tautomycin (1), a specific inhibitor of protein serine/threonine phosphatases, has been achieved through an esterification of the C1.–C7. fragment A′ 7 4 with the C1–C26 fragment B′ 7 6 by a modified Yamaguchi method and an aldol reaction of the C17–C26 fragment C 5 with the C1–C16 fragment D 6 using LDA as key steps. The fragments 5 and 6 have been
    会聚立体控制(+)的总合成- tautomycin(1),蛋白质的特异性抑制剂丝氨酸/苏氨酸磷酸酶,已经通过C的酯化实现1. -C 7片段A' 7 4与C 1 - ç 26片段B' 7 6通过改进的山口方法和C的醛醇缩合反应17 -C 26片段C 5与C 1 -C 16片段d 6使用LDA作为关键步骤。片段5和6 分别以立体声控制的方式构造。
  • Synthesis of the tetraene fragment of calyculins having natural configurations
    作者:Fumiaki Yokokawa、Yasumasa Hamada、Takayuki Shioiri
    DOI:10.1016/0040-4039(93)88104-q
    日期:1993.10
    Synthesis of the tetraene fragment 2, the C1–C12 portion, of calyculins (1f) has been accomplished by use of the Stille coupling of the vinyl iodide (C6-C12) unit 4 with the nitrile (C1–C5) unit 3 followed by converting to the vinyl iodide function according to the Barton's procedure.
    四烯片段的合成2中,C 1 -C 12部分,calyculins(的1 f)曾通过使用的Stille的乙烯基碘的(C联接完成6 -C 12)单元4与腈(C 1 - C 5)单元3,然后按照巴顿法将其转化为碘乙烯官能团。
  • Synthetic studies on tautomycin synthesis of Segment B
    作者:Katsunori Tsuboi、Yoshiyasu Ichikawa、Atsushi Naganawa、Minoru Isobe、Makoto Ubukata、Kiyoshi Isono
    DOI:10.1016/s0040-4020(97)00228-7
    日期:1997.4
    The synthesis of Segment B corresponding to the C26–C17 portion of tautomycin was accomplished by coupling reaction between the epoxide (Sub-segment B-1) and the dithiane (Sub-segment B-2). The degradation product of tautomycin corresponding to the C26–C19 portion was also synthesized from Sub-segment B-1.
    对应于互变霉素C26-C17部分的B部分的合成是通过环氧化物(B-1部分)和二噻吩(B-2部分)之间的偶合反应完成的。还从子段B-1合成了对应于C26–C19部分的互变霉素的降解产物。
  • Efficient Synthesis of Okadaic Acid. 2. Synthesis of the C1−C14 Domain and Completion of the Total Synthesis
    作者:Steven F. Sabes、Rebecca A. Urbanek、Craig J. Forsyth
    DOI:10.1021/ja973286p
    日期:1998.3.1
    the full details of the preparation of a synthetic intermediate representing carbons 1−14 (C1−C14) of the marine natural product okadaic acid (1), the coupling of this fragment with the previously prepared C15−C38 domain, and the completion of an efficient total synthesis of 1. The C1−C14 intermediate was prepared in 11 steps and ∼20% overall yield from a functionalized δ-valerolactone derivative representing
    这里描述了代表海洋天然产物冈田酸 (1) 的碳 1-14 (C1-C14) 的合成中间体的制备的全部细节,该片段与先前制备的 C15-C38 结构域的偶联,以及完成了 1 的有效全合成。 C1-C14 中间体分 11 个步骤制备,总产率约为 20%,来自代表 C3-C8 of 1 的功能化 δ-戊内酯衍生物。 1,7-二氧杂螺[5.5] undec-4-ene 系统,然后使用顺式-(S)-乳酸pivalidene 烯醇化物掺入完整的C1-C2 α-羟基、α-甲基羧酸酯部分。完整的 C1-C14 中间体在另外五个步骤中被转化为 1。通过 C14 醛和 C15 β-酮膦酸酯部分将 C1-C14 片段与 1 的 C15-C38 结构域偶联提供了 1 的完整碳骨架,在 C16 处带有酮,在 C19 处带有混合甲基缩醛。减少 C16 酮...
  • Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. Tandem Substituted Tetrahydrofuran Formation and Stereoselective Reduction: Synthesis of the C17-C22 Subunit of Ionomycin
    作者:Y. Guindon、C. Yoakim、V. Gorys、W. W. Ogilvie、D. Delorme、J. Renaud、G. Robinson、J.-F. Lavallee、A. Slassi
    DOI:10.1021/jo00084a040
    日期:1994.3
    The tandem iodoetherification reaction and stereoselective reduction of acyclic radicals has been used in the stereocontrolled synthesis of substituted tetrahydrofurans. Such a tetrahydrofuran intermediate is regioselectively cleaved using Me(2)BBr to reveal the acyclic array 2 which represents the C-17-C-22 subunit of ionomycin. In experiments that provide for a better understanding of hydrogen transfer reactions involving acyclic radicals, a significant improvement in the stereoselectivity is observed when the two substituents at the stereogenic center alpha to the radical are imbedded in a cycle (''cycle effect''). A mechanistic rationale is discussed.
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