ipecoside | 15401-60-2

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: ipecoside
• 英文别名: methyl (2S,3R,4S)-4-[[(1R)-2-acetyl-6,7-dihydroxy-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-3-ethenyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carboxylate
• CAS: 15401-60-2
• 化学式: C₂₇H₃₅NO₁₂
• 分子量: 565.574
• InChiKey: QISXROCIXKXUPS-OWVLCBNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  196
• 氢给体数：
  6
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 ipecoside 以 甲醇 、 乙醚 为溶剂， 以77.4%的产率得到6,7-Di-O-methylipecoside
  参考文献：
  名称：

  Hoefle, Gerhard; Nagakura, Naotaka; Zenk, Meinhart H., Chemische Berichte, 1980, vol. 113, # 2, p. 566 - 576

  摘要：

  DOI：
• 作为产物：
  描述：

  重氮甲烷 、 Ipecosidic acid 以 甲醇 、 乙醚 为溶剂， 以1.5 mg的产率得到6,7-Di-O-methylipecoside
  参考文献：
  名称：

  来自 Cephaelis ipecacuanha 的六种四氢异喹啉-单萜葡萄糖苷

  摘要：

  摘要 从生药“吐根”中分离得到六种新型四氢异喹啉-单萜苷、6-O-甲基-异戊二烯苷、异异氰酸酯、去甲基黄芩苷、新异松苷、7-O-甲基-异异戊二烯苷和3,4-异异戊二烯糖苷。连同伊佩考苷、阿兰糖苷、鼠尾草苷和 7-脱氢木糖苷。通过光谱和化学方法确定了新糖苷的结构。还讨论了这些糖苷的生物发生。

  DOI：

  10.1016/s0031-9422(00)98265-7

文献信息

• Tetrahydroisoquinoline-monoterpene glucosides from Alangium lamarckii and Cephaelis ipecacuanha
  作者：Atsuko Itoh、Takao Tanahashi、Naotaka Nagakura、Hidekazu Nayeshiro

  DOI：10.1016/s0031-9422(00)97080-8

  日期：1994.5

  Abstract From the dried fruits of Alangium lamarckii, a novel tetrahydroisoquinoline-monoterpene glucoside, 3-O-demethyl-2-O-methylalangiside, was isolated along with alangiside. Re-examination of the constituents of the roots of Cephaelis ipecacuanha led to the isolation and identification of this same compound, as well as alangiside and that of another new glucoside, 7-O-methylipecoside. The structures

  摘要 从海棠果干果中分离得到一种新型四氢异喹啉-单萜葡萄糖苷3-O-demethyl-2-O-methylalangiside。对 Cephaelis ipecacuanha 根成分的重新检查导致分离和鉴定了相同的化合物，以及阿兰糖苷和另一种新的葡萄糖苷 7-O-甲基岩脂苷。这两种新糖苷的结构是通过光谱和化学方法确定的。
• Method of collecting materials exuded from plant roots
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP1400166A1

  公开（公告）日：2004-03-24

  A method of collecting materials exuded from plant roots is provided by growing the plant roots in a growing medium that is surrounded by a membrane such that moisture is released into the growing medium from the membrane whilst materials exuded from the plant roots are retained within the growing medium by the membrane, wherein the membrane is a hydrophobic porous membrane or a hydrophilic non-porous membrane.

  提供了一种收集植物根部渗出物质的方法，该方法是将植物根部种植在生长介质中，生长介质被一层膜包围，水分从膜释放到生长介质中，而植物根部渗出的物质被膜保留在生长介质中，其中膜是疏水多孔膜或亲水无孔膜。
• Method for extracting and refining alkaloids from ipecac
  申请人：CHENGDU HERBPURIFY CO., LTD.

  公开号：US10258661B2

  公开（公告）日：2019-04-16

  Provided is a method for extracting and refining alkaloids from ipecac, comprising: (1) grinding ipecac, adding acidic methanol/ethanol solution for extraction, obtaining an extraction solution A, concentrating under a reduced pressure, and obtaining a concentrated solution B; (2) using reversed-phase polymer filler J for adsorption, and performing desorption by washing with water, collecting a washing solution C, eluting with an alcoholic solution E and collecting a desorption solution D; (3) injecting the washing solution C and the desorption solution D into a preparative high performance liquid chromatograph for separation and purification respectively, to collect a solution G, and a solution H and a solution I respectively; and (4) concentrating the solutions G, H and I, which are then subjected to reversed-phase polymer filler K for adsorption respectively; eluting them respectively after adsorption with an alcoholic solution F; concentrating obtained eluates to dryness; and then performing vacuum drying.

  本发明提供了一种提取和精制依帕可生物碱的方法，包括(1) 研磨依帕酸，加入酸性甲醇/乙醇溶液进行提取，得到提取液A，减压浓缩，得到浓缩液B； (2) 使用反相聚合物填料J进行吸附，用水洗涤进行解吸，收集洗涤液C，用乙醇溶液E洗脱，收集解吸液D；(3) 将洗涤溶液 C 和解吸溶液 D 分别注入制备型高效液相色谱仪进行分离和纯化，分别收集溶液 G、溶液 H 和溶液 I；以及 (4) 将溶液 G、H 和 I 浓缩，然后分别用反相聚合物填料 K 进行吸附，吸附后分别用酒精溶液 F 进行洗脱，将获得的洗脱液浓缩至干，然后进行真空干燥。
• METHOD FOR MODIFYING ROOT GROWTH
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP1199923B1

  公开（公告）日：2005-03-16
• METHOD FOR EXTRACTING AND REFINING ALKALOIDS FROM IPECAC
  申请人：CHENGDU HERBPURIFY CO., LTD.

  公开号：US20170368126A1

  公开（公告）日：2017-12-28

  Provided is a method for extracting and refining alkaloids from ipecac, comprising: (1) grinding ipecac, adding acidic methanol/ethanol solution for extraction, obtaining an extraction solution A, concentrating under a reduced pressure, and obtaining a concentrated solution B; (2) using reversed-phase polymer filler J for adsorption, and performing desorption by washing with water, collecting a washing solution C, eluting with an alcoholic solution E and collecting a desorption solution D; (3) injecting the washing solution C and the desorption solution D into a preparative high performance liquid chromatograph for separation and purification respectively, to collect a solution G, and a solution H and a solution I respectively; and (4) concentrating the solutions G, H and I, which are then subjected to reversed-phase polymer filler K for adsorption respectively; eluting them respectively after adsorption with an alcoholic solution F; concentrating obtained eluates to dryness; and then performing vacuum drying.