5,7,2',4'-Tetrabenzyloxy-5'-methoxy-isoflavon | 67978-84-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 5,7,2',4'-Tetrabenzyloxy-5'-methoxy-isoflavon
• 英文别名: 5,7-bis-benzyloxy-3-(2,4-bis-benzyloxy-5-methoxy-phenyl)-chromen-4-one；3-[5-Methoxy-2,4-bis(phenylmethoxy)phenyl]-5,7-bis(phenylmethoxy)chromen-4-one；3-[5-methoxy-2,4-bis(phenylmethoxy)phenyl]-5,7-bis(phenylmethoxy)chromen-4-one
• CAS: 67978-84-1
• 化学式: C₄₄H₃₆O₇
• 分子量: 676.766
• InChiKey: RTIISCUODRQPBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  51
• 可旋转键数：
  14
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5,7,2',4'-Tetrabenzyloxy-5'-methoxy-isoflavon 在 palladium on activated charcoal 邻四氯苯醌 、 氢气 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 10.0h， 生成 desmoxyphyllin A
  参考文献：
  名称：

  Facile synthesis of polyhydroxycoumaronochromones with quinones: synthesis of alkylpolyhydroxy- and alkoxycoumaronochromones from 2′-hydroxyisoflavones

  摘要：

  4 ' ,5,7-Trihydroxy- or 8-alkyl-4 ' .5,7-trihvclroxycoumaronochromones were synthesized by oxidative cyclization of the corresponding 2 ' -hydroxyisoflavones with o-chloranil under mild conditions. By contrast, alkoxycoumaronochromones were synthesized by oxidative cyclization of the corresponding 2 ' -hydroxyisoflavones with DDQ. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01234-5
• 作为产物：
  描述：

  Acetic acid 3,5-bis-benzyloxy-2-[2-(2,4-bis-benzyloxy-5-methoxy-phenyl)-3,3-dimethoxy-propionyl]-phenyl ester 在 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 2.0h， 生成 5,7,2',4'-Tetrabenzyloxy-5'-methoxy-isoflavon
  参考文献：
  名称：

  Facile synthesis of polyhydroxycoumaronochromones with quinones: synthesis of alkylpolyhydroxy- and alkoxycoumaronochromones from 2′-hydroxyisoflavones

  摘要：

  4 ' ,5,7-Trihydroxy- or 8-alkyl-4 ' .5,7-trihvclroxycoumaronochromones were synthesized by oxidative cyclization of the corresponding 2 ' -hydroxyisoflavones with o-chloranil under mild conditions. By contrast, alkoxycoumaronochromones were synthesized by oxidative cyclization of the corresponding 2 ' -hydroxyisoflavones with DDQ. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01234-5

文献信息

• Facile synthesis of polyhydroxycoumaronochromones with quinones: synthesis of alkylpolyhydroxy- and alkoxycoumaronochromones from 2′-hydroxyisoflavones
  作者：Masao Tsukayama、Akihiro Oda、Yasuhiko Kawamura、Masaki Nishiuchi、Kazuyo Yamashita

  DOI：10.1016/s0040-4039(01)01234-5

  日期：2001.8

  4 ' ,5,7-Trihydroxy- or 8-alkyl-4 ' .5,7-trihvclroxycoumaronochromones were synthesized by oxidative cyclization of the corresponding 2 ' -hydroxyisoflavones with o-chloranil under mild conditions. By contrast, alkoxycoumaronochromones were synthesized by oxidative cyclization of the corresponding 2 ' -hydroxyisoflavones with DDQ. (C) 2001 Elsevier Science Ltd. All rights reserved.