ethyl 4-tert-butyloxycarbonylamino-1-methylimidazole-2-carboxylate | 128293-63-0

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 4-tert-butyloxycarbonylamino-1-methylimidazole-2-carboxylate
• 英文别名: 4-[(tert-butoxycarbonyl)amino]-1-methylimidazole-2-carboxylic acid ethyl ester；Ethyl 4-((tert-butoxycarbonyl)amino)-1-methyl-1H-imidazole-2-carboxylate；ethyl 1-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]imidazole-2-carboxylate
• CAS: 128293-63-0
• 化学式: C₁₂H₁₉N₃O₄
• 分子量: 269.301
• InChiKey: VKDFVUFMCCONBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  82.4
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2933290090
• 危险性防范说明：
  P264,P280,P302+P352,P305+P351+P338,P332+P313,P337+P313,P362
• 危险性描述：
  H315,H319

反应信息

• 作为反应物：
  描述：

  ethyl 4-tert-butyloxycarbonylamino-1-methylimidazole-2-carboxylate 在 sodium hydroxide 作用下， 以94%的产率得到4-叔丁氧羰基氨基-1-甲基-1H-咪唑-2-甲酸
  参考文献：
  名称：

  Grehn, Leif; Ding, Lu; Ragnarsson, Ulf, Acta Chemica Scandinavica, 1990, vol. 44, # 1, p. 67 - 74

  摘要：

  DOI：
• 作为产物：
  描述：

  1-甲基-4-硝基咪唑-2-羧酸乙酯 在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 乙醚 、 乙醇 、 乙腈 为溶剂， 25.0~40.0 ℃ 、101.33 kPa 条件下， 反应 34.17h， 生成 ethyl 4-tert-butyloxycarbonylamino-1-methylimidazole-2-carboxylate
  参考文献：
  名称：

  Grehn, Leif; Ding, Lu; Ragnarsson, Ulf, Acta Chemica Scandinavica, 1990, vol. 44, # 1, p. 67 - 74

  摘要：

  DOI：

文献信息

• Vectors for dna delivery
  申请人：——

  公开号：US20030207400A1

  公开（公告）日：2003-11-06

  The present invention pertains to novel products suitable for use as gene delivery systems in which nucleic acid is linked to a ligand in order to facilitate delivery of the nucleic acid to a target cell or sub-cellular compartment via uptake of the ligand. More particularly, the present invention pertains to vectors comprising: (a) a double stranded DNA (dsDNA) having at least one target sequence; and, (b) a chimeric molecule comprising: (i) a sequence specific polyamide (SSP) moiety bound non-covalently to said target sequence; and, (ii) a ligand moiety linked covalently to said sequence specific polyamide. The present invention also pertains to compositions comprising such chimeric molecules and vectors; methods for making such chimeric molecules and vectors; and methods of using such chimeric molecules and vectors, e.g., to deliver nucleic acid vectors to cells or sub-cellular compartments.

  本发明涉及新型产品，适用于用作基因传递系统，其中核酸与配基连接，以便通过配基的摄取促进核酸传递到目标细胞或亚细胞区域。更具体地，本发明涉及包括：（a）至少具有一个目标序列的双链DNA（dsDNA）；以及（b）包括的嵌合分子：（i）与所述目标序列非共价结合的序列特异性聚酰胺（SSP）基团；以及（ii）与所述序列特异性聚酰胺共价连接的配基基团。本发明还涉及包含这种嵌合分子和向量的组合物；制备这种嵌合分子和向量的方法；以及使用这种嵌合分子和向量的方法，例如将核酸向量传递到细胞或亚细胞区域。
• METHOD FOR PRODUCING PYRROLE-IMIDAZOLE (POLY)AMIDE
  申请人：KANEKA CORPORATION

  公开号：US20220153727A1

  公开（公告）日：2022-05-19

  The purpose of the present invention is to provide a method for producing a pyrrole-imidazole (poly)amide compound with the rapidly improved conversion rates, high yield and high reproducibility in the reaction forming an amide bond between a carboxy group binding to a pyrrole and an amino group binding to an imidazole. A method for producing a pyrrole-imidazole (poly)amide by reacting an aminoimidazole carboxylic acid derivative with a pyrrolecarboxylic acid derivative in the presence of a heterocyclic aromatic compound as a solvent.

  本发明的目的是提供一种生产吡咯-咪唑(聚)酰胺化合物的方法，该方法在形成连接到吡咯的羧基和连接到咪唑的氨基之间的酰胺键反应中具有快速改善的转化率、高收率和高重现性。一种在杂环芳香化合物作为溶剂的情况下，通过将氨基咪唑羧酸衍生物与吡咯羧酸衍生物反应来制备吡咯-咪唑(聚)酰胺的方法。
• Solid Phase Synthesis of Polyamides Containing Imidazole and Pyrrole Amino Acids
  作者：Eldon E. Baird、Peter B. Dervan

  DOI：10.1021/ja960720z

  日期：1996.1.1

  The solid phase synthesis of sequence specific DNA binding polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids is described. Two monomer building blocks, Boc-Py-OBt ester and Boc-Im acid, are prepared on a 50 g scale without column chromatography. Using commercially available Boc-beta-alanine-Pam resin, cycling protocols were optimized to afford high stepwise coupling yields (>99%). Deprotection by aminolysis affords up to 100 mg quantities of polyamide. Solid phase methodology increases both the number and complexity of minor groove binding polyamides which can be synthesized and analyzed with regard to DNA binding affinity and sequence specificity. The solid phase synthesis of a representative eight-residue polyamide is reported.
• GREHN, LEIF;DING, LU;RAGNARSSON, ULF, ACTA CHEM. SCAND., 44,(1990) N, C. 67-74
  作者：GREHN, LEIF、DING, LU、RAGNARSSON, ULF

  DOI：——

  日期：——
• VECTORS FOR DNA DELIVERY
  申请人：ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.

  公开号：EP1290198A2

  公开（公告）日：2003-03-12