Cedeodarin;6-甲基二氢槲皮素 | 31076-39-8

• 物质功能分类: 天然产物 - 黄酮类化合物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: Cedeodarin;6-甲基二氢槲皮素
• 英文名称: Cedeodarin
• 英文别名: (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methyl-2,3-dihydrochromen-4-one
• CAS: 31076-39-8
• 化学式: C₁₆H₁₄O₇
• 分子量: 318.28
• InChiKey: KPCWWZLBHGSXPW-JKSUJKDBSA-N

物化性质

• 沸点：
  692.9±55.0 °C(Predicted)
• 密度：
  1.632±0.06 g/cm3(Predicted)
• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• PREPARATIONS WITH C-METHYL FLAVONOIDS
  申请人：Analyticon Discovery GmbH

  公开号：EP3643183A1

  公开（公告）日：2020-04-29

  Suggested are preparations, comprising or consisting of (a) C-methyl flavonoids, a salt of C-methyl flavonoids and/or an extract containing C-methyl flavonoids, and (b) at least one inorganic salt or mineral substance.

  建议的制剂包括或由以下物质组成 (a) C-甲基类黄酮、C-甲基类黄酮的盐和/或含有 C-甲基类黄酮的提取物，以及 (b) 至少一种无机盐或矿物质。
• METHODS OF PREVENTING TUMOR METASTASIS, TREATING AND PROGNOSING CANCER AND IDENTIFYING AGENTS WHICH ARE PUTATIVE METASTASIS INHIBITORS
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US20150290233A1

  公开（公告）日：2015-10-15

  A method of preventing tumor metastasis with the proviso that the tumor is not glioma is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2), thereby preventing tumor metastasis. Also, provided is a method of treating cancer. The method comprising, administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2) and an inhibitor of a cell surface receptor associated with an onset or progression of cancer, thereby treating cancer.
• SYNAPTOJANIN-2 INHIBITORS FOR USE IN THE TREATMENT OF CANCER
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20170042857A1

  公开（公告）日：2017-02-16

  Disclosed herein are synaptojanin-2 inhibitors, and novel methods and uses utilizing same for preventing tumor metastasis, treating cancer or inhibiting synaptojanin-2. Compounds disclosed herein include chlorhexidine and pyrvinium, the compound having the formula: and compounds characterized by the general formula: X-L-[(Y)i-(Z)j]-(L-X)k and/or by the general formula: wherein L, X, Y, Z, D, E, i, j and k are as defined herein.