O-(2,6-Dichlorbenzyl)tyrosin | 40298-69-9

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: O-(2,6-Dichlorbenzyl)tyrosin
• 英文别名: O4-(2,6-Dichlorobenzyl)-L-tyrosine；2-amino-3-[4-[(2,6-dichlorophenyl)methoxy]phenyl]propanoic acid
• CAS: 40298-69-9
• 化学式: C₁₆H₁₅Cl₂NO₃
• 分子量: 340.206
• InChiKey: FTZFICPDLOOUKO-UHFFFAOYSA-N

物化性质

• 熔点：
  215-216 °C
• 沸点：
  503.8±50.0 °C(Predicted)
• 密度：
  1.382±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2922509090

反应信息

• 作为反应物：
  描述：

  O-(2,6-Dichlorbenzyl)tyrosin 、 2-(3,4-methylenedioxy-6-nitrobenzo-1-yl)-acetic acid 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以46.15%的产率得到N-[(6-nitro-1,3-benzodioxol-5-yl)acetyl]-O⁴-(2,6-dichlorobenzyl)tyrosinamide
  参考文献：
  名称：

  Synthesis, antitumour and antimicrobial activities of new peptidyl derivatives containing the 1,3-benzodioxole system

  摘要：

  Two series of 5 and 6-substituted 1,3-benzodioxole peptidyl derivatives were synthesized and evaluated as antitumour and anti microbial agents. The compounds that could be conveniently prepared in a few steps processes from natural safrole have been characterised by IR and H-1-NMR spectroscopy. In vivo antitumor activity tests showed that some of the compounds were able to inhibit carcinoma S-180 tumour growth in mice. The in vitro antimicrobial activity of all compounds revealed that they are able to promote the growth of some organisms, including Bacillas subtilis. (C) 2004 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.09.007

文献信息

• [EN] INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES<br/>[FR] INHIBITEURS D'ENZYMES D'ACTIVATION DE FACTEUR DE CROISSANCE
  申请人：UNIV WASHINGTON

  公开号：WO2016144654A1

  公开（公告）日：2016-09-15

  The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.

  本发明通常涉及对抑制肝细胞生长因子激活剂、麦曲丝蛋白、赫普星、Xa因子或凝血酶等的化合物有用的化合物。本发明还涉及使用抑制剂化合物的各种方法，包括通过向需要的受试者施用有效量的抑制剂来治疗恶性肿瘤、癌前病变或癌症。
• [EN] COMPOUNDS AND METHODS FOR TREATING CANCER, VIRAL INFECTIONS, AND ALLERGIC CONDITIONS<br/>[FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT DU CANCER, D'INFECTIONS VIRALES ET D'AFFECTIONS ALLERGIQUES
  申请人：JANETKA JAMES

  公开号：WO2020264187A1

  公开（公告）日：2020-12-30

  The present invention generally relates to compounds that are useful for inhibiting one or more trypsin-like S1 serine proteases, HGFA, matriptase, hepsin, KLK5 and/or TMPRSS2 as well as cysteine proteases including trypsin-like cysteine proteases (e.g. Cathepsin B). The present invention also relates to various methods of using the inhibitor compounds to treat or prevent viral infections, including those caused by coronaviruses and influenza, conditions associated with KLK5, various malignancies, pre-malignant conditions, and cancer.

  本发明通常涉及一种用于抑制一个或多个类似胰蛋白酶的S1丝氨酸蛋白酶，HGFA、matriptase、hepsin、KLK5和/或TMPRSS2以及胱氨酸蛋白酶包括类似胰蛋白酶的胱氨酸蛋白酶（例如Cathepsin B）的化合物。本发明还涉及使用这些抑制剂化合物治疗或预防病毒感染的各种方法，包括由冠状病毒和流感病毒引起的感染，与KLK5相关的疾病、各种恶性肿瘤、癌前病变和癌症。
• [EN] ANTI-CANCER COMPOUNDS AND METHODS RELATED THERETO<br/>[FR] COMPOSES ANTICANCEREUX ET PROCEDES S'Y RAPPORTANT
  申请人：STEWART JOHN M

  公开号：WO2000011022A1

  公开（公告）日：2000-03-02

  The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula (I): [ACA]n-X wherein, X is a linker group having 2-5 functional groups or is absent, n = 1, and ACA is selected from the group consisting of Formula (II), Formula (III), Formula (IV), Formula (V), and Formula (VI), as described herein. Other compounds described herein are defined by the Formula (VII), as described herein.

  本发明提供了一种有用的化合物，可用于抑制肿瘤生长和诱导细胞凋亡。一般来说，抗癌药物（ACA）由公式（I）描述：[ACA]n-X其中，X是具有2-5个功能基团的连接基团或不存在，n = 1，而ACA选自本文所述的公式（II），公式（III），公式（IV），公式（V）和公式（VI）的群组。本文还描述了其他化合物，其由公式（VII）所定义，如本文所述。
• SILYLALKYLOXYARYL COMPOUNDS AND METHODS FOR TREATING CANCER
  申请人：THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

  公开号：US20160159832A1

  公开（公告）日：2016-06-09

  Silylalkyloxyaryl compounds useful as anti-cancer agents. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of melanoma, colon, neuroblastoma, bladder, breast, lung, pancreatic, melanoma, sarcoma, lymphoma or gastric cancer.

  Silylalkyloxyaryl化合物可用作抗癌剂。这些化合物和含有它们的制药组合物特别适用于黑色素瘤、结肠癌、神经母细胞瘤、膀胱癌、乳腺癌、肺癌、胰腺癌、黑色素瘤、肉瘤、淋巴瘤或胃癌的治疗。
• Inhibitors of growth factor activation enzymes
  申请人：Janetka James W.

  公开号：US11130780B2

  公开（公告）日：2021-09-28

  The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.

  本发明一般涉及可用于抑制一种或多种肝细胞生长因子激活剂、淀粉酶、肝素、Xa因子或凝血酶的化合物。 本发明还涉及使用抑制剂化合物的各种方法，包括通过向有需要的受试者施用有效量的抑制剂来治疗恶性肿瘤、恶性肿瘤前期病症或癌症。