(1aR,1bS,4aR,7aS,7bR,9R,9aR)-4a,7b,9-Trihydroxy-3-hydroxymethyl-1,1,6-trimethyl-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-cyclopropa[3,4]benzo[1,2-e]azulen-5-one | 175521-09-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1aR,1bS,4aR,7aS,7bR,9R,9aR)-4a,7b,9-Trihydroxy-3-hydroxymethyl-1,1,6-trimethyl-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-cyclopropa[3,4]benzo[1,2-e]azulen-5-one
• CAS: 175521-09-2
• 化学式: C₁₉H₂₆O₅
• 分子量: 334.412
• InChiKey: DQOMASSUYCWHHK-KVBTVOGJSA-N

反应信息

• 作为反应物：
  描述：

  (1aR,1bS,4aR,7aS,7bR,9R,9aR)-4a,7b,9-Trihydroxy-3-hydroxymethyl-1,1,6-trimethyl-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-cyclopropa[3,4]benzo[1,2-e]azulen-5-one 在 N-[(2,4-二氯苯氧基)-甲氧基硫代膦酰]丙-2-胺 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 吡啶 为溶剂， 反应 90.0h， 生成
  参考文献：
  名称：

  Stereocontrolled syntheses of phorbol analogs and evaluation of their binding affinity to PKC

  摘要：

  Stereocontrolled syntheses of a series of phorbol analogs, and evaluation of their potential to bind to the signal transduction enzyme protein kinase C (PKC) are described. The relationship between the structures of these analogs and their PKC binding affinity is also discussed.

  DOI：

  10.1016/0040-4039(94)02455-k
• 作为产物：
  描述：

  (1R,2S,3S,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-nitro-but-1-enyl]-7,7-dimethyl-3-(2-trimethylsilanyl-ethoxymethoxy)-3-vinyl-bicyclo[4.1.0]heptane 在 镍 氢气 、 硼酸 、 对氯苯异氰酸酯 、 三乙胺 作用下， 反应 11.0h， 生成 (1aR,1bS,4aR,7aS,7bR,9R,9aR)-4a,7b,9-Trihydroxy-3-hydroxymethyl-1,1,6-trimethyl-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-cyclopropa[3,4]benzo[1,2-e]azulen-5-one
  参考文献：
  名称：

  Stereocontrolled syntheses of phorbol analogs and evaluation of their binding affinity to PKC

  摘要：

  Stereocontrolled syntheses of a series of phorbol analogs, and evaluation of their potential to bind to the signal transduction enzyme protein kinase C (PKC) are described. The relationship between the structures of these analogs and their PKC binding affinity is also discussed.

  DOI：

  10.1016/0040-4039(94)02455-k