3,4-二氢-2-甲基-2-(4,8,12-三甲基三癸)-2H-1-苯丙吡喃-6-醇 | 58166-19-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 3,4-二氢-2-甲基-2-(4,8,12-三甲基三癸)-2H-1-苯丙吡喃-6-醇
• 英文名称: (2R)-2-methyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
• 英文别名: α-tocopherol；Tocol；Tocol, (2R)-；(2R)-2-methyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
• CAS: 58166-19-1
• 化学式: C₂₆H₄₄O₂
• 分子量: 388.634
• InChiKey: DFUSDJMZWQVQSF-XLGIIRLISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,4-二氢-2-甲基-2-(4,8,12-三甲基三癸)-2H-1-苯丙吡喃-6-醇 、 以 水 为溶剂， 反应 1008.0h， 生成 d,l-tocotrienol
  参考文献：
  名称：

  Method of improving animal tissue quality by supplementing the animal diet with oleic acid and selected tocols

  摘要：

  本发明提供了一种改善动物肉质的新方法。该方法包括给动物饲喂含有油酸和选择的生育酚的饲料，以有效提高肉质。该方法可用于反刍动物和非反刍动物。

  公开号：

  US20060004100A1
• 作为产物：
  描述：

  Phytyl quinol 在 tocopherol cyclase from spheroplasts of Anabaena variabilis 作用下， 以 丙酮 为溶剂， 生成 3,4-二氢-2-甲基-2-(4,8,12-三甲基三癸)-2H-1-苯丙吡喃-6-醇
  参考文献：
  名称：

  The substrate specificity of tocopherol cyclase

  摘要：

  The substrate specificity of the enzyme tocopherol cyclase from the blue-green algae Anabaena variabilis (Cyanobacteria) was investigated with 11 substrate analogues revealing the significance of three major recognition sites: (i) the OH group at C(1) of the hydroquinone, (ii) the (E) configuration of the double bond, and (iii) the length of the lipophilic side chain. Experiments with two affinity matrices suggest that substrates approach the enzyme's active site with the hydrophobic tail. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0968-0896(96)00125-3

文献信息

• Nucleic acid sequences to proteins involved in tocopherol synthesis
  申请人：——

  公开号：US20030170833A1

  公开（公告）日：2003-09-11

  Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.

  提供核酸序列和方法，用于生产具有改变生育酚含量和组成的植物和种子。该方法特别适用于增加植物中的生育酚水平，并在宿主植物细胞中提供理想的生育酚组成。
• Substrates coated with antioxidant compositions and method for
  申请人：PPG Industries, Inc.

  公开号：US05747162A1

  公开（公告）日：1998-05-05

  The present invention includes curable compositions adapted to coat substrates. In one embodiment, the composition includes an antioxidant selected from terpene materials; vitamin materials different from the terpene materials; and combinations thereof in an amount of about 0.00001 weight percent to about 5 weight percent based upon the weight of the substrate. In another embodiment, the composition includes (a) an antioxidant selected from terpene materials; vitamin materials different from the terpene materials; and combinations thereof in an amount effective to inhibit oxidation of the composition; and (b) a film-forming material capable of forming a substantially uniform continuous coating on the substrate. Also included are substrates and sized glass fibers coated with such compositions and fabrics woven from such coated fibers. Other aspects of the present invention include methods for inhibiting the oxidation of a coating composition adapted to coat substrates.

  本发明包括适用于涂覆基材的可固化组合物。在一个实施例中，该组合物包括从萜类材料中选取的抗氧化剂；与萜类材料不同的维生素材料；以及二者的组合物，其重量百分比约为基材重量的0.00001％至5％。在另一个实施例中，该组合物包括(a)从萜类材料中选取的抗氧化剂；与萜类材料不同的维生素材料；以及二者的组合物，其含量有效地抑制组合物的氧化；以及(b)能够在基材上形成基本均匀连续涂层的成膜材料。还包括涂有这种组合物的基材和尺寸合适的玻璃纤维以及由涂有这种涂层纤维编织的织物。本发明的其他方面还包括用于抑制适用于涂覆基材的涂层组合物氧化的方法。
• TOCOPHEROL-MODIFIED THERAPEUTIC DRUG COMPOUNDS
  申请人：Zhang Yuehua

  公开号：US20080045559A1

  公开（公告）日：2008-02-21

  Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.

  维生素E改性治疗药物化合物；包括该化合物的乳液、微乳液和胶束制剂；制备该化合物和制剂的方法；给予该化合物和制剂的方法；以及使用该化合物和制剂治疗疾病的方法。
• Nucleic acid sequences to proteins involved in isoprenoid synthesis
  申请人：Calgene LLC

  公开号：US06541259B1

  公开（公告）日：2003-04-01

  Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.

  提供了核酸序列和方法，用于生产具有改变生育酚含量和组成的植物和种子。该方法特别适用于增加植物中的生育酚水平，并在宿主植物细胞中提供理想的生育酚组成。
• NUCLEIC ACID SEQUENCES TO PROTEINS INVOLVED IN TOCOPHEROL SYNTHESIS
  申请人：Subramaniam Sai S.

  公开号：US20100216204A1

  公开（公告）日：2010-08-26

  Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.

  提供了核酸序列和方法，用于产生具有改变的生育酚含量和组成的植物和种子。该方法特别适用于增加植物中的生育酚水平，并在宿主植物细胞中提供理想的生育酚组成。