7-O-methylluteone | 122290-50-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 7-O-methylluteone
• 英文别名: 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-enyl)chromen-4-one
• CAS: 122290-50-0
• 化学式: C₂₁H₂₀O₆
• 分子量: 368.386
• InChiKey: AZPLXDBZIQMMMT-UHFFFAOYSA-N

物化性质

• 沸点：
  621.5±55.0 °C(Predicted)
• 密度：
  1.342±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-O-methylluteone 在 氨 、 氧气 、 还原型辅酶II(NADPH)四钠盐 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 0.5h， 生成 8-(2,4-Dihydroxy-phenyl)-2-(1-hydroxy-1-methyl-ethyl)-4-methoxy-2,3-dihydro-furo[2,3-f]chromen-9-one
  参考文献：
  名称：

  Cyclization of a Prenylated IsoflavoneviaEnzymatic Epoxidation

  摘要：

  A cell-free system of Botrytis cinerea, which can metabolize prenylated isoflavones into the corresponding dihydropyrano- and dihydrofurano-isoflavones, revealed the transformation to be initially catalyzed by a microsomal monooxygenase to yield an epoxy intermediate. The enzyme activity was markedly enhanced by pretreating the mycelia with 6-prenylnaringenin, and was dependent on NADPH and O2.

  DOI：

  10.1271/bbb.60.171

文献信息

• PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR LIGANDS AND PROCESS FOR PRODUCING THE SAME
  申请人：KANEKA CORPORATION

  公开号：EP1440688A1

  公开（公告）日：2004-07-28

  The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

  本发明简便高效地提供了一种过氧化物酶体增殖体激活受体配体，以及一种用于改善胰岛素抵抗或预防和/或改善胰岛素抵抗综合征的组合物，其中含有该配体作为活性成分。 本发明涉及一种过氧化物酶体增殖体激活受体配体，它包括一种前黄酮类化合物、一种不包括前黄酮类化合物的查尔酮衍生物、一种不包括前黄酮类化合物的黄酮醇衍生物，以及可作为药物制剂或食品或饮料的盐、苷和/或酯化物质；一种含有上述配体的组合物；一种含有上述配体的植物提取物；以及一种生产上述提取物的工艺。
• METHOD OF PRODUCTION OF STEVIOL GLYCOSIDE SWEETENERS WITH IMPROVED FLAVOR PROFILES
  申请人：The Coca-Cola Company

  公开号：EP3766362A1

  公开（公告）日：2021-01-20

  Steviol glycoside compositions comprising certain proportions of rebaudioside D, rebaudioside M, rebaudioside A, rebaudioside N, rebaudioside O, and rebaudioside E are provided. Sweetener compositions comprising the steviol glycoside compositions and additional substances are also provided. Consumables, particularly beverages and beverage products containing said steviol glycoside compositions, and sweetener compositions comprising the same, are also provided. Methods of preparing the sweetener compositions and consumables are also detailed herein.

  提供了由一定比例的甜菊糖甙 D、甜菊糖甙 M、甜菊糖甙 A、甜菊糖甙 N、甜菊糖甙 O 和甜菊糖甙 E 组成的甜菊糖甙组合物。此外，还提供了由甜菊醇糖苷组合物和其他物质组成的甜味剂组合物。还提供了消费品，特别是含有所述甜菊醇糖苷组合物和甜味剂组合物的饮料和饮料产品。本文还详细介绍了甜味剂组合物和消费品的制备方法。
• Hair cosmetic composition
  申请人：KAO CORPORATION

  公开号：US10959925B2

  公开（公告）日：2021-03-30

  The hair cosmetic composition of the present invention, which is a one-agent type or a multi-agent type hair cosmetic composition, contains, the following components (A) to (D), the component (C) content, relative to the total composition of the hair cosmetic composition, being 0.1 mass % or higher and lower than 20 mass %: (A): a compound selected from the group consisting of glyoxylic acid, a glyoxylic acid hydrate, a glyoxylate salt, and a glyoxylamide; (B): a phenolic compound having an electron-donating group on at least one m-position and having a hydrogen atom on at least one of the o-positions and the p-position, wherein the electron-donating group on the m-position may form, together with an adjacent carbon atom, a benzene ring optionally substituted with hydroxyl group(s); (C): an organic solvent having a boiling point of 100° C. or higher; and (D): water.

  本发明的头发化妆品组合物是一种单药剂型或多药剂型头发化妆品组合物，含有以下成分（A）至（D），其中成分（C）的含量相对于头发化妆品组合物的总成分而言，大于或等于 0.1 质量%，小于 20 质量%： (A): 选自乙醛酸、乙醛酸水合物、乙醛酸盐和乙醛酰胺组成的化合物； (B) 一种酚类化合物，其至少一个 m 位上有一个电子供体，至少一个 o 位和 p 位上有一个氢原子，其中 m 位上的电子供体可与相邻的碳原子一起形成一个任选被羟基取代的苯环； (C) 沸点为 100 摄氏度或更高的有机溶剂；以及 (D) 水。
• Peroxisome proliferator activated receptor ligands and process for producing the same
  申请人：Mae Tatsumasa

  公开号：US20050014819A1

  公开（公告）日：2005-01-20

  The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenyl flavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

  本发明简便高效地提供了一种过氧化物酶体增殖体激活受体配体，以及一种用于改善胰岛素抵抗或预防和/或改善胰岛素抵抗综合征的组合物，其中含有该配体作为活性成分。本发明涉及一种过氧化物酶体增殖体激活受体配体，它包括一种前酰基类黄酮、一种不包括前酰基类黄酮的查尔酮衍生物、一种不包括前酰基类黄酮的黄酮醇衍生物，以及可作为药物制剂或食品或饮料的盐、苷和/或酯化物质；一种含有上述配体的组合物；一种含有上述配体的植物提取物；以及一种生产上述提取物的工艺。
• Fad-dependent epoxidase as a key enzyme in fungal metabolism of prenylated flavonoids
  作者：Mitsuharu Tanaka、Satoshi Tahara

  DOI：10.1016/s0031-9422(97)00322-1

  日期：1997.10

  Crude protein extracts from Botrytis cinerea preincubated with 6-prenylnaringenin (6-PN) for 20 hr catalysed the prenyl epoxidation of 7-O-methyl-luteone. The resulting epoxide was non-enzymatically and slowly converted into the corresponding dihydrofurano derivative in a buffer solution at pH 7.5. Preparation of cell-free extracts in the presence of 6-PN from the mycelia without preincubation with 6-PN hardly showed the epoxidizing activity. These facts revealed that the substrate analogue 6-PN has a role as an enzyme inducer rather than stabilizer. The enzyme reaction depends on molecular oxygen and NADPH. Low amounts of FAD were necessary for maximal enzyme activity. The enzymatic activity was not inhibited by various inhibitors of cytochrome P-450 tested, in addition to carbon monoxide and cytochrome c. The results indicated that this enzyme does not belong to the monooxygenases dependent on cytochrome P-450, but to those dependent on FAD. About half of. the total enzyme activity was found in the 125 000 g supernatant, but the specific activity for the epoxidation reaction in the 125 000 g pellet was 3.7-fold higher than in the soluble fraction. The enzyme showed high specificity to monoprenyl isoflavones. Finally, a preliminary experiment using a cell-free system from white lupin hypocotyls resulted in formation of small amounts of an epoxide corresponding to 7-O-methyl-luteone used as the substrate. (C) 1997 Elsevier Science Ltd.