2-ketobicyclo<2.2.1>heptane-1-carboxylic acid | 2534-70-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-ketobicyclo<2.2.1>heptane-1-carboxylic acid
• 英文别名: 2-Oxonorbornan-1-carbonsaeure；2-Oxobicyclo[2.2.1]heptane-1-carboxylic acid
• CAS: 2534-70-5
• 化学式: C₈H₁₀O₃
• 分子量: 154.166
• InChiKey: ZKMOOBXRINLMKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-ketobicyclo<2.2.1>heptane-1-carboxylic acid 在 草酰氯 、 bis(triphenylphosphine)copper(I) tetrahydroborate 、 N,N-二甲基甲酰胺 、 三苯基膦 作用下， 以 乙醚 、 正己烷 、 丙酮 、 苯 为溶剂， 反应 4.5h， 生成 (+/-)-1-vinyl-2-norbornanone
  参考文献：
  名称：

  Paquette, Leo A.; Teleha, Christopher A.; Taylor, Richard T., Journal of the American Chemical Society, 1990, vol. 112, # 1, p. 265 - 277

  摘要：

  DOI：
• 作为产物：
  描述：

  exo,endo-2-bromobicyclo<2.2.1>heptane-1-carboxylic acid 在 jones reagent 、 碳酸氢钠 作用下， 以 乙醚 、 水 为溶剂， 反应 2.0h， 生成 2-ketobicyclo<2.2.1>heptane-1-carboxylic acid
  参考文献：
  名称：

  Bicyclo[3.2.2]non-1-ene: matrix isolation and spectroscopic characterization of a moderately strained bridgehead olefin

  摘要：

  Bicyclo[3.2.2]non-1-ene was generated in low-temperature matrices and in fluid solutions by photodecomposition of bicyclo[2.2.2]oct-1-yldiazomethane and its photorearrangement product, 3-(bicyclo[2.2.2]oct-1-yl)diazirine. It was characterized by IR and UV absorption and by H-1 and C-13 NMR spectroscopy. Further evidence for the proposed structure was provided by self-trapping and by the spectral effects of deuteration on the olefinic carbon. Observed IR spectra and isotopic shifts agree well with the results of semiempirical (MNDO) and ab initio (SCF/6-31G*) calculations.

  DOI：

  10.1021/jo00066a018

文献信息

• [EN] CONVENIENT PROCESS FOR THE PREPARATION OF STATINS<br/>[FR] PROCÉDÉ PRATIQUE POUR LA PRÉPARATION DE STATINES
  申请人：ITALIANA SINT SPA

  公开号：WO2014128022A1

  公开（公告）日：2014-08-28

  Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.

  本发明的对象是一种改进的过程，用于制备合成他汀的关键中间体。
• Convenient Process for the Preparation of Statins
  申请人：F.IS.- FABBRICA ITALIANA SINTETICI S.P.A.

  公开号：US20150344439A1

  公开（公告）日：2015-12-03

  Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.

  本发明的目的是提供一种改进的方法，用于合成他汀类药物的关键中间体的制备。
• Polyurethane (meth)acrylates and processes for preparing same
  申请人：UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION

  公开号：EP0542219A2

  公开（公告）日：1993-05-19

  This invention relates to polyurethane (meth)acrylates that are prepared from certain liquid hydrocarbon diols and/or derivatives of said liquid hydrocarbon diols, polyfunctional isocyanates, and hydroxyalkyl acrylates and methacrylates. The polyurethane (meth)acrylates are useful as decorative and functional coatings, inks, adhesives, sealants, and formed parts.

  本发明涉及由某些液态烃二醇和/或上述液态烃二醇的衍生物、多官能异氰酸酯、羟烷基丙烯酸酯和甲基丙烯酸酯制备的聚氨酯（甲基）丙烯酸酯。聚氨酯（甲基）丙烯酸酯可用作装饰性和功能性涂料、油墨、粘合剂、密封剂和成型部件。
• Polyesters for coating compositions which are sprayed with compressed fluids as viscosity reducing diluents
  申请人：UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION

  公开号：EP0545110A1

  公开（公告）日：1993-06-09

  The present invention relates to polyesters of branched aliphatic diols with 8 or more carbon atoms which are particularly suitable in coating compositions which are sprayed with compressed fluids which act as viscosity reducing diluents.

  本发明涉及具有 8 个或更多碳原子的支链脂肪族二元醇的聚酯，这种聚酯特别适用于使用作为降粘稀释剂的压缩流体进行喷涂的涂料组合物。
• Conformal coating compositions
  申请人：UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION

  公开号：EP0542218A1

  公开（公告）日：1993-05-19

  This invention relates to curable conformal coating compositions prepared from certain liquid hydrocarbon diols and/or derivatives of said liquid hydrocarbon diols, cycloaliphatic epoxides, and optionally other epoxides, polyols, vinyl esters, onium salt photoinitiators and other ingredients. The conformal coating compositions are curable with actinic or thermal energy and are useful as protective coatings for electrical and electronic devices.

  本发明涉及可固化的保形涂料组合物，由某些液态烃二醇和/或上述液态烃二醇的衍生物、环脂族环氧化物以及可选的其它环氧化物、多元醇、乙烯基酯、鎓盐光引发剂和其它成分制备而成。保形涂料组合物可以用放电或热能固化，可用作电气和电子设备的保护涂层。