allyl 3-O-benzoyl-4,6-O-p-methoxybenzylidene-β-D-galactopyranosyl-(1-> 3)-2-acetamido-2-deoxy-4,6-di-O-pivaloyl-α-D-galactopyranoside | 527687-48-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: allyl 3-O-benzoyl-4,6-O-p-methoxybenzylidene-β-D-galactopyranosyl-(1-> 3)-2-acetamido-2-deoxy-4,6-di-O-pivaloyl-α-D-galactopyranoside
• CAS: 527687-48-5
• 化学式: C₄₂H₅₅NO₁₅
• 分子量: 813.896
• InChiKey: CXBRSVQUGKZNHD-KYSRSINHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.79
• 重原子数：
  58.0
• 可旋转键数：
  13.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  192.84
• 氢给体数：
  2.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  S-ethyl 3,4-di-O-acetyl-2-O-methyl-1-thio-β-L-fucopyranoside 、 allyl 3-O-benzoyl-4,6-O-p-methoxybenzylidene-β-D-galactopyranosyl-(1-> 3)-2-acetamido-2-deoxy-4,6-di-O-pivaloyl-α-D-galactopyranoside 在 N-碘代丁二酰亚胺 、 三氟甲磺酸 、 MS 4 Angstroem 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 以48%的产率得到allyl 3,4-di-O-acetyl-2-O-methyl-α-L-fucopyranosyl-(1-> 2)-3-O-benzoyl-4,6-O-p-methoxybenzylidene-β-D-galactopyranosyl-(1-> 3)-2-acetamido-2-deoxy-4,6-di-O-pivaloyl-α-D-galactopyranoside
  参考文献：
  名称：

  Synthesis of neoglycoproteins containing O-methylated trisaccharides related to excretory/secretory antigens of Toxocara larvae

  摘要：

  The disaccharides allyl beta-D-galactopyranosyl-(1 --> 3)-2-acetamido-2-deoxy-beta- and alpha-D-galactopyranoside 10a and 10b and the trisaccharides allyl 2-O-methyl-alpha-L-fucopyranosyl-(1 --> 2)-beta-D-galactopyranosyl-(1--> 3)-2-acetamido-2-deoxy-beta- and alpha-D-galactopyranoside 18a and 18b have been prepared using stepwise assembly of the sugar units. The glycosidic linkages were formed employing the trichloroacetimidate procedure for the attachment of the galactopyranosyl residue and N-iodosuccinimide/triflic acid activation of an ethyl 1-thiofucopyranoside donor for fucosylation. Deprotection furnished the allyl glycosides which were converted into cysteamine-spacered ligands, activated with thiophosgene and subsequently linked to bovine serum albumin. The neoglycoproteins serve as immunoreagents to determine epitope specificities of monoclonal antibodies directed against highly immunogenic O-glycans located at the surface of Toxocara larvae. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(02)00355-5
• 作为产物：
  描述：

  烯丙基 2-乙酰氨基-2-脱氧-alpha-D-吡喃葡萄糖苷 在 吡啶 、 三氟甲磺酸酐 、 4 A molecular sieve 、 三氟化硼乙醚 、 sodium methylate 、 对甲苯磺酸 作用下， 以 甲醇 、 二氯甲烷 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 71.0h， 生成 allyl 3-O-benzoyl-4,6-O-p-methoxybenzylidene-β-D-galactopyranosyl-(1-> 3)-2-acetamido-2-deoxy-4,6-di-O-pivaloyl-α-D-galactopyranoside
  参考文献：
  名称：

  Synthesis of neoglycoproteins containing O-methylated trisaccharides related to excretory/secretory antigens of Toxocara larvae

  摘要：

  The disaccharides allyl beta-D-galactopyranosyl-(1 --> 3)-2-acetamido-2-deoxy-beta- and alpha-D-galactopyranoside 10a and 10b and the trisaccharides allyl 2-O-methyl-alpha-L-fucopyranosyl-(1 --> 2)-beta-D-galactopyranosyl-(1--> 3)-2-acetamido-2-deoxy-beta- and alpha-D-galactopyranoside 18a and 18b have been prepared using stepwise assembly of the sugar units. The glycosidic linkages were formed employing the trichloroacetimidate procedure for the attachment of the galactopyranosyl residue and N-iodosuccinimide/triflic acid activation of an ethyl 1-thiofucopyranoside donor for fucosylation. Deprotection furnished the allyl glycosides which were converted into cysteamine-spacered ligands, activated with thiophosgene and subsequently linked to bovine serum albumin. The neoglycoproteins serve as immunoreagents to determine epitope specificities of monoclonal antibodies directed against highly immunogenic O-glycans located at the surface of Toxocara larvae. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(02)00355-5