tricyclo[3 .2.1 .0^2,4]octane-3-carboxylic acid N-ethylamide | 1020401-14-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: tricyclo[3 .2.1 .0^2,4]octane-3-carboxylic acid N-ethylamide
• 英文别名: N-ethyltricyclo[3.2.1.02,4]octane-3-carboxamide
• CAS: 1020401-14-2
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: LQOTZLJVUHJVTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-(ethoxycarbonyl)tricyclo[3.2.1.0^2,4]octane 在 草酰氯 、 N,N-二甲基甲酰胺 、 sodium hydroxide 作用下， 以 乙醚 、 乙醇 、 水 为溶剂， 反应 23.5h， 生成 tricyclo[3 .2.1 .0^2,4]octane-3-carboxylic acid N-ethylamide
  参考文献：
  名称：

  Substituted bicyclo [4.1.0] heptane-7-carboxylic acid amides and derivatives thereof as food flavor substances

  摘要：

  本发明涉及使用式（I）的化合物，其中：R1、R2、R3、R4、R5、R6、R7和R8在每种情况下独立地表示氢、具有1至6个C原子的烷基基团或具有2至6个C原子的烯基基团，但至少其中之一的基团R1、R2、R7和R8以及至少另外一个基团R1、R2、R3、R4、R5、R6、R7和R8不是氢，其中独立地两个基团R1、R2、R3、R4、R5、R6、R7和R8也可以一起表示具有一个或多个桥接碳原子的桥；Y1和Y2独立地表示氢、甲基或乙基；以及Ra和Rb独立地表示氢、具有1至6个C原子的烷基基团、具有2至6个C原子的烯基基团或具有3至6个C原子的环烷基团作为一种食品香味物质。

  公开号：

  US08487133B2

文献信息

• SUBSTITUTED BICYCLO [4.1.0] HEPTANE-7-CARBOXYLIC ACID AMIDES AND DERIVATIVES THEREOF AS FOOD FLAVOR SUBSTANCES
  申请人：Looft Jan

  公开号：US20100189863A1

  公开（公告）日：2010-07-29

  The present invention relates to the use of a compound of the Formula (I) wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 denote in each case independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, or an alkenyl radical with 2 to 6 C atoms, with the proviso that at least one of the radicals R 1 , R 2 , R 7 and R 8 and at least one further of the radicals R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are not hydrogen, wherein independently of one another also two of the radicals R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 can together denote a bridge with one or more bridge C atoms; Y 1 and Y 2 denote independently of one another hydrogen, methyl or ethyl; and R a and R b denote independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, an alkenyl radical with 2 to 6 C atoms or a cycloalkyl radical with 3 to 6 C atoms as a food flavor substance.

  本发明涉及使用式（I）化合物，其中：R1、R2、R3、R4、R5、R6、R7和R8各自独立地表示氢、具有1至6个碳原子的烷基基团或具有2至6个碳原子的烯基基团，但至少其中一个基团R1、R2、R7和R8以及至少另一个基团R1、R2、R3、R4、R5、R6、R7和R8不是氢，其中R1、R2、R3、R4、R5、R6、R7和R8的两个基团也可以独立地共同表示具有一个或多个桥接碳原子的桥；Y1和Y2各自独立地表示氢、甲基或乙基；以及Ra和Rb各自独立地表示氢、具有1至6个碳原子的烷基基团、具有2至6个碳原子的烯基基团或具有3至6个碳原子的环烷基团，作为食品香味物质。
• SUBSTITUTED BICYCLOÝ4.1.0¨HEPTANE-7-CARBOXYLIC ACID AMIDES AND DERIVATIVES THEREOF AS FOOD FLAVOR SUBSTANCES
  申请人：Symrise GmbH & Co. KG

  公开号：EP2079322A1

  公开（公告）日：2009-07-22
• US8487133B2
  申请人：——

  公开号：US8487133B2

  公开（公告）日：2013-07-16
• [EN] SUBSTITUTED BICYCLO[4.1.0]HEPTANE-7-CARBOXYLIC ACID AMIDES AND DERIVATIVES THEREOF AS FOOD FLAVOR SUBSTANCES<br/>[FR] Amides d'acide bicyclo[4.1.0]heptane-7-carboxylique substitués et dérivés de ces derniers en tant que substances aromatisantes pour les aliments
  申请人：SYMRISE GMBH & CO KG

  公开号：WO2008046895A1

  公开（公告）日：2008-04-24

  [EN] The present invention relates to the use of a compound of the Formula (I) wherein: R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ denote in each case independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, or an alkenyl radical with 2 to 6 C atoms, with the proviso that at least one of the radicals R¹, R², R⁷ and R⁸ and at least one further of the radicals R¹, R², R³, R⁴, R⁵, R⁶, R⁷ a nd R⁸ are not hydrogen, wherein independently of one another also two of the radicals R¹, R², R³, R⁴, R⁵, R⁶, R⁷ a nd R⁸can together denote a bridge with one or more bridge C atoms; Y¹ and Y² denote independently of one another hydrogen, methyl or ethyl; and R^a and R^b denote independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, an alkenyl radical with 2 to 6 C atoms or a cycloalkyl radical with 3 to 6 C atoms as a food flavor substance.
  [FR] La présente invention concerne l'utilisation d'un composé de la formule (I) dans laquelle : R¹, R², R³, R⁴, R⁵, R⁶, R⁷ et R⁸ représentent dans chaque cas, indépendamment les uns des autres, de l'hydrogène, un radical alkyle comprenant 1 à 6 atomes de carbone, ou un radical alcényle comprenant 2 à 6 atomes de carbone, à condition qu'au moins un des radicaux R¹, R², R⁷ et R⁸ et au moins un autre des radicaux R¹, R², R³, R⁴, R⁵, R⁶, R⁷ et R⁸ ne soient pas de l'hydrogène. Deux des radicaux R¹, R², R³, R⁴, R⁵, R⁶, R⁷ et R⁸ _,
• Substituted bicyclo [4.1.0] heptane-7-carboxylic acid amides and derivatives thereof as food flavor substances
  申请人：Looft Jan

  公开号：US08487133B2

  公开（公告）日：2013-07-16

  The present invention relates to the use of a compound of the Formula (I) wherein: R1, R2, R3, R4, R5, R6, R7 and R8 denote in each case independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, or an alkenyl radical with 2 to 6 C atoms, with the proviso that at least one of the radicals R1, R2, R7 and R8 and at least one further of the radicals R1, R2, R3, R4, R5, R6, R7 and R8 are not hydrogen, wherein independently of one another also two of the radicals R1, R2, R3, R4, R5, R6, R7 and R8 can together denote a bridge with one or more bridge C atoms; Y1 and Y2 denote independently of one another hydrogen, methyl or ethyl; and Ra and Rb denote independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, an alkenyl radical with 2 to 6 C atoms or a cycloalkyl radical with 3 to 6 C atoms as a food flavor substance.

  本发明涉及使用式（I）的化合物，其中：R1、R2、R3、R4、R5、R6、R7和R8在每种情况下独立地表示氢、具有1至6个C原子的烷基基团或具有2至6个C原子的烯基基团，但至少其中之一的基团R1、R2、R7和R8以及至少另外一个基团R1、R2、R3、R4、R5、R6、R7和R8不是氢，其中独立地两个基团R1、R2、R3、R4、R5、R6、R7和R8也可以一起表示具有一个或多个桥接碳原子的桥；Y1和Y2独立地表示氢、甲基或乙基；以及Ra和Rb独立地表示氢、具有1至6个C原子的烷基基团、具有2至6个C原子的烯基基团或具有3至6个C原子的环烷基团作为一种食品香味物质。