3-O-acetyl-1,2-O-isopropylidene-5,6-di-O-methanesulfonyl-α-D-galactofuranose | 848310-50-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-O-acetyl-1,2-O-isopropylidene-5,6-di-O-methanesulfonyl-α-D-galactofuranose
• 英文别名: [(3aR,5R,6S,6aR)-5-[(1R)-1,2-bis(methylsulfonyloxy)ethyl]-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-yl] acetate
• CAS: 848310-50-9
• 化学式: C₁₃H₂₂O₁₁S₂
• 分子量: 418.443
• InChiKey: KNBOOXVFXHURCQ-YBXAARCKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.88
• 重原子数：
  26.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  140.73
• 氢给体数：
  0.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  3-O-acetyl-1,2-O-isopropylidene-5,6-di-O-methanesulfonyl-α-D-galactofuranose 在 硫酸 、 sodium acetate 、 对甲苯磺酸 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 3.0h， 生成 (4-nitro)phenyl 2,3,5,6-tetra-O-acetyl-α-L-altrofuranoside
  参考文献：
  名称：

  Non-natural aldofuranosides as substrates of a β-glucosidase

  摘要：

  Based on glycosidase inhibitory activities of some known 1,4-iminoalditols, four aldofuranosides, (4-nitro)phenyl beta-D-glucofuranoside, -beta-D-galactofuranoside, -alpha-L-idofuranoside and -alpha-L-altrofuranoside, were identified as possible substrates of glucosidases and galactosidases. Three of them were found to be accepted by the beta-glucosidase from Agrobacterium sp. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.11.027
• 作为产物：
  描述：

  3-O-acetyl-1,2:5,6-di-O-isopropylidene-α-D-galactofuranose 在 吡啶 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 20.0h， 生成 3-O-acetyl-1,2-O-isopropylidene-5,6-di-O-methanesulfonyl-α-D-galactofuranose
  参考文献：
  名称：

  Non-natural aldofuranosides as substrates of a β-glucosidase

  摘要：

  Based on glycosidase inhibitory activities of some known 1,4-iminoalditols, four aldofuranosides, (4-nitro)phenyl beta-D-glucofuranoside, -beta-D-galactofuranoside, -alpha-L-idofuranoside and -alpha-L-altrofuranoside, were identified as possible substrates of glucosidases and galactosidases. Three of them were found to be accepted by the beta-glucosidase from Agrobacterium sp. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.11.027

文献信息

• LEE, CHEANG KUAN, CARBOHYDR. RES., 177,(1988) 247-252
  作者：LEE, CHEANG KUAN

  DOI：——

  日期：——