(-)-chiracamphox | 165038-32-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (-)-chiracamphox
• 英文别名: (1'R,4R,4'S)-2',2'-dimethylspiro[1,3-oxazolidine-4,3'-bicyclo[2.2.1]heptane]-2-one
• CAS: 165038-32-4
• 化学式: C₁₁H₁₇NO₂
• 分子量: 195.261
• InChiKey: IIRXFQFVVUAFGC-VHSKPIJISA-N

物化性质

• 熔点：
  227-231 °C
• 沸点：
  331.93°C (rough estimate)
• 密度：
  1.0654 (rough estimate)
• 稳定性/保质期：

  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3
• 海关编码：
  2934999090

SDS

Name:	(-)-Chiracamphox Material Safety Data Sheet
Synonym:	(5R)-6,6-Dimethyl-7,10-methylen-3-oxa-1-azaspiro[4.5]decan-2-one
CAS:	165038-32-4

Section 1 - Chemical Product MSDS Name:(-)-Chiracamphox Material Safety Data Sheet
Synonym:(5R)-6,6-Dimethyl-7,10-methylen-3-oxa-1-azaspiro[4.5]decan-2-one

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
165038-32-4	(-)-Chiracamphox	100	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid breathing dust.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 165038-32-4: Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear a chemical apron.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Needles
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 227 - 229 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C11H17NO2
Molecular Weight: 195.26

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 165038-32-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
(-)-Chiracamphox - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 165038-32-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 165038-32-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 165038-32-4 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  (-)-chiracamphox 在 sodium hydroxide 、 乙醇 、 对甲苯磺酸 、 间氯过氧苯甲酸 作用下， 以 乙醚 、 丙酮 为溶剂， 反应 108.0h， 生成 (-)-camphoxyl radical
  参考文献：
  名称：

  几种新型旋光活性硝酰基自由基的合成

  摘要：

  由对映体纯的双环萜类化合物制备旋光的硝酰基自由基。可以容易地制备衍生自市售恶唑烷酮（（-）-1）的（-）-樟脑基自由基（-）-4和衍生自（-）-hen烯的（+）-樟脑氧基自由基（+）-4，构象刚性，对映异构体硝氧基自由基。（-）-樟脑磺酸用于制备两个另外的光学活性硝酰基自由基9和12。

  DOI：

  10.1016/0040-4039(96)01800-x

文献信息

• A concise synthesis of (−)-Dihydroprotolichesterinic acid via consecutive stereocontrolled 1,4-conjugate addition and syn-aldol condensation reactions
  作者：Malcolm R. Banks、Ian M. Dawson、Ian Gosney、Philip K.G. Hodgson、Paul Thorburn

  DOI：10.1016/0040-4039(95)00560-y

  日期：1995.5

  synthesised in 6 steps and 57% overall yield by a strategy employing the camphene-derived chiral auxiliary 2 to construct the three contiguous stereogenic centres in consecutive stereocontrolled 1,4-conjugate addition and syn-aldol reactions.

  （-）-Dihydroprotolichesterinic acid 1a是通过6个步骤合成的，总产率为57％，该策略采用了由camp烯衍生的手性助剂2在连续的立体控制的1,4-共轭加成和顺式-羟醛反应中构建三个连续的立体发生中心。