7-(3-Aminopropoxy)-3-(4-methoxyphenyl)chromen-2-one | 1413983-14-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 7-(3-Aminopropoxy)-3-(4-methoxyphenyl)chromen-2-one
• 英文别名: 7-(3-aminopropoxy)-3-(4-methoxyphenyl)chromen-2-one
• CAS: 1413983-14-8
• 化学式: C₁₉H₁₉NO₄
• 分子量: 325.364
• InChiKey: YJQGQQKEBQATCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  70.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7-(3-Aminopropoxy)-3-(4-methoxyphenyl)chromen-2-one 在 monoamine oxidase type-A 作用下， 以 aq. phosphate buffer 为溶剂， 生成 7-hydroxy-3-(4-methoxyphenyl)-2H-chromen-2-one
  参考文献：
  名称：

  Rapid and sensitive fluorescent probes for monoamine oxidases B to A at low concentrations

  摘要：

  A new monoamine oxidase (MAO) fluorescent probe that displays response for both monoamine oxidase type-A (MAO-A) and monoamine oxidase type-B (MAO-B) is reported. This sensing platform does not require any additional enzymes or reagents. Furthermore, the probes have better sensitivity and shorter response time by comparison with similar probes, and have potentials in differentiation of MAO-A and MAO-B upon further optimization. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.074
• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以92%的产率得到7-(3-Aminopropoxy)-3-(4-methoxyphenyl)chromen-2-one
  参考文献：
  名称：

  Rapid and sensitive fluorescent probes for monoamine oxidases B to A at low concentrations

  摘要：

  A new monoamine oxidase (MAO) fluorescent probe that displays response for both monoamine oxidase type-A (MAO-A) and monoamine oxidase type-B (MAO-B) is reported. This sensing platform does not require any additional enzymes or reagents. Furthermore, the probes have better sensitivity and shorter response time by comparison with similar probes, and have potentials in differentiation of MAO-A and MAO-B upon further optimization. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.074

文献信息

• Rapid and sensitive fluorescent probes for monoamine oxidases B to A at low concentrations
  作者：Yexiang Zhang、Yufang Xu、Shaoying Tan、Lin Xu、Xuhong Qian

  DOI：10.1016/j.tetlet.2012.09.074

  日期：2012.12

  A new monoamine oxidase (MAO) fluorescent probe that displays response for both monoamine oxidase type-A (MAO-A) and monoamine oxidase type-B (MAO-B) is reported. This sensing platform does not require any additional enzymes or reagents. Furthermore, the probes have better sensitivity and shorter response time by comparison with similar probes, and have potentials in differentiation of MAO-A and MAO-B upon further optimization. (C) 2012 Elsevier Ltd. All rights reserved.