(1S)-2,10-N-[4-methyl-2-phenylthiazoline-4-carbonyl]camphorsultam | 725728-39-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1S)-2,10-N-[4-methyl-2-phenylthiazoline-4-carbonyl]camphorsultam
• 英文别名: [(1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.01,5]decan-4-yl]-[(4R)-4-methyl-2-phenyl-5H-1,3-thiazol-4-yl]methanone；[(1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-azatricyclo[5.2.1.01,5]decan-4-yl]-[(4R)-4-methyl-2-phenyl-5H-1,3-thiazol-4-yl]methanone
• CAS: 725728-39-2
• 化学式: C₂₁H₂₆N₂O₃S₂
• 分子量: 418.581
• InChiKey: UDKNLJAWDJHQMB-WWEWDKITSA-N

物化性质

• 熔点：
  138-140 °C
• 沸点：
  567.9±60.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (1S)-2,10-N-[4-methyl-2-phenylthiazoline-4-carbonyl]camphorsultam 在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以89%的产率得到(2R)-bornane-10,2-sultam
  参考文献：
  名称：

  A Facile, Inexpensive and Scalable Route to Thiol-Protected α-Methyl Cysteine

  摘要：

  A facile, scalable synthesis of alpha-methyl cysteine with three alternate thiol protecting groups (trityl, allyl and tert-butyl) is described. The thiol-protected amino acids are obtained in six steps from L-cysteine ethyl ester and are ideally suited for a range of natural product and solid-phase peptide synthesis applications.

  DOI：

  10.1055/s-0032-1318316
• 作为产物：
  描述：

  苯甲亚胺酸乙酯盐酸盐 在 四丁基溴化铵 、 三甲基铝 、 三乙胺 作用下， 以 甲醇 、 正庚烷 、 二氯甲烷 、 甲苯 为溶剂， 反应 25.85h， 生成 (1S)-2,10-N-[4-methyl-2-phenylthiazoline-4-carbonyl]camphorsultam
  参考文献：
  名称：

  A Facile, Inexpensive and Scalable Route to Thiol-Protected α-Methyl Cysteine

  摘要：

  A facile, scalable synthesis of alpha-methyl cysteine with three alternate thiol protecting groups (trityl, allyl and tert-butyl) is described. The thiol-protected amino acids are obtained in six steps from L-cysteine ethyl ester and are ideally suited for a range of natural product and solid-phase peptide synthesis applications.

  DOI：

  10.1055/s-0032-1318316

文献信息

• A Facile, Inexpensive and Scalable Route to Thiol-Protected α-Methyl Cysteine
  作者：Alison Hulme、Heather Johnston

  DOI：10.1055/s-0032-1318316

  日期：——

  A facile, scalable synthesis of alpha-methyl cysteine with three alternate thiol protecting groups (trityl, allyl and tert-butyl) is described. The thiol-protected amino acids are obtained in six steps from L-cysteine ethyl ester and are ideally suited for a range of natural product and solid-phase peptide synthesis applications.