8(14)-二氢松香酸 | 19407-37-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 8(14)-二氢松香酸
• 英文名称: 13β-Abieten-(8,14)-saeure-(18)
• 英文别名: 13αH-abiet-8(14)-en-18-oic acid；13αH-Abiet-8(14)-en-18-saeure；13αH-Abieten-(8(14))-saeure-(18)；8(14)-Abietenic acid；(1R,4aR,4bS,7S,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,7,9,10,10a-decahydrophenanthrene-1-carboxylic acid
• CAS: 19407-37-5
• 化学式: C₂₀H₃₂O₂
• 分子量: 304.473
• InChiKey: BTAURFWABMSODR-NZODBCNPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8(14)-二氢松香酸 在 对甲苯磺酸 作用下， 生成 (+)-13β-abiet-8-en-18-oic acid
  参考文献：
  名称：

  Structure and stereochemistry of reduction products of abietictype resin acids

  摘要：

  DOI：

  10.1021/jo01258a005
• 作为产物：
  描述：

  abietic acid dipentylammonium salt 在 氨 、 lithium 作用下， 生成 8(14)-二氢松香酸
  参考文献：
  名称：

  Structure and stereochemistry of reduction products of abietictype resin acids

  摘要：

  DOI：

  10.1021/jo01258a005

文献信息

• Calcium-sensing receptor gene polymorphisms in primary hyperparathyroidism
  作者：F. Cetani、S. Borsari、E. Vignali、E. Pardi、A. Picone、L. Cianferotti、G. Rossi、P. Miccoli、A. Pinchera、C. Marcocci

  DOI：10.1007/bf03345085

  日期：2002.7

  The calcium-sensing receptor (CaR) polymorphism A986S has been found to be associated with higher serum calcium levels in normal subjects, suggesting that this amino acid change might decrease the inhibitory activity of the mutated receptor, render the parathyroid cells more prone to proliferate, and eventually increase the risk of developing primary hyperparathyroidism (PHPT). The aim of the present

  已经发现钙敏感受体（CaR）多态性A986S与正常受试者的较高血清钙水平有关，这表明这种氨基酸变化可能会降低突变受体的抑制活性，使甲状旁腺细胞更易于增殖，并最终增加患原发性甲状旁腺功能亢进症（PHPT）的风险。本研究的目的是研究PHPT患者中该基因和其他2种已知的CaR多态性（R990G和Q1011 E）的频率及其对其表型的影响。我们研究了103名患有PHPT的意大利患者和148名健康的意大利受试者，并比较了50对配对的性别，年龄和地理来源的结果。CaR基因第7外显子的片段，包含3个感兴趣的多态性基因座（A986S，R990G和Q1011E），通过PCR扩增并测序。评估血清钙和PTH水平，BMD以及其他生化和临床参数。103名PHPT患者中A9865，R990G和Q1011 E多态性的频率分布分别为39.8％，5.8％和2.0％。在50对匹配的患者和对照中，3个CaR多态性的频率没有差异。
• Clinico-pathological profile of pediatric lymphadenopathy
  作者：M. Pradeep Reddy、Nekhil Moorchung、Arun Chaudhary

  DOI：10.1007/bf02724385

  日期：2002.12

  Objective: To study the clinico-pathological profile of significant pediatric peripheral lymphadenopathy and to arrrive at an etiological diagnosis. Methods: Prospective study in a tertiary care hospital setting. One hundred consecutive children reporting to pediatric OPD from 1 January 1995 to 31 December 1998, aged 1 month to 12 years were studied. Results: The commonest aetiology diagnosed was tubercular lymphadenitis in 35% cases, followed by chronic tonsillopharyngitis in 15% cases. Lymphomas, AIDS and infectious mononucleosis constituted 3, 2 and 1 cases each. Aetiology could not be ascertained in 44 (44%) children even after detailed haematological, microbiological, radiological and serological investigations. FNAC's sensitivity and specificity as compared to 'gold standard of excision lymph node biopsy was 94% and 100% respectively. Conclusion: Tubercular lymphadenitis was the commonest treatable entity of significant pediatric peripheral lymphadenopathy. A majority of the cases even after thorough evaluation, remained undiagnosed. FNAC as a diagnostic modality is almost as sensitive and as specific as excision lymph node biopsy when an adequate aspirate is examined by expert eyes.
• Velluz et al., Bulletin de la Societe Chimique de France, 1954, p. 401,406
  作者：Velluz et al.

  DOI：——

  日期：——
• Zur Kenntnis der Diterpene. (52. Mitteilung). Über das Chinonaddukt und die Permanganatoxydation der Lävo-pimarsäure
  作者：L. Ruzicka、St. Kaufmann

  DOI：10.1002/hlca.194102401169

  日期：——
• Polyterpene und Polyterpenoide CXIX. Über die Anzahl und die gegenseitige Lage der Doppelbindungen bei der Laevo-pimarsäure
  作者：L. Ruzicka、R. G. R. Bacon

  DOI：10.1002/hlca.193702001205

  日期：——