13β-Abieten-(8,14)-saeure-(18)-methylester | 33892-17-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 13β-Abieten-(8,14)-saeure-(18)-methylester
• 英文别名: 13β-isopropyl-podocarpen-(8(14))-oic acid-(15)-methyl ester；13β-Isopropyl-podocarpen-(8(14))-saeure-(15)-methylester；methyl (1R,4aR,4bS,7S,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,7,9,10,10a-decahydrophenanthrene-1-carboxylate
• CAS: 33892-17-0
• 化学式: C₂₁H₃₄O₂
• 分子量: 318.5
• InChiKey: QKIYXILRDUTSOO-BMOGTECYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  13β-Abieten-(8,14)-saeure-(18)-methylester 在 吡啶 、 四氧化锇 作用下， 生成 8α.14α-Dihydroxy-13β-abietan-18-saeuremethylester
  参考文献：
  名称：

  Structure and stereochemistry of reduction products of abietictype resin acids

  摘要：

  DOI：

  10.1021/jo01258a005
• 作为产物：
  描述：

  新松脂酸 在 氨 、 lithium 作用下， 生成 13β-Abieten-(8,14)-saeure-(18)-methylester
  参考文献：
  名称：

  Structure and stereochemistry of reduction products of abietictype resin acids

  摘要：

  DOI：

  10.1021/jo01258a005

文献信息

• Synthesis of fichtelite and related derivatives of abietane
  作者：Albert W. Burgstahler、John N. Marx

  DOI：10.1021/jo01258a006

  日期：1969.6
• Lombard; Ebelin, Bulletin de la Societe Chimique de France, 1953, p. 930,933
  作者：Lombard、Ebelin

  DOI：——

  日期：——
• Thyroid function is more strongly associated with body impedance than anthropometry in healthy subjects
  作者：A. Sartorio、S. Ferrero、L. Trecate、G. Bedogni

  DOI：10.1007/bf03345086

  日期：2002.7

  Since fat-free tissues are responsible for 95% of basal energy expenditure, fat-free mass is expected to be a better determinant of thyroid size and function than anthropometry. We tested the hypothesis that fat-free tissues as qualitatively determined by body resistance (R) at 50 kHz are more strongly associated with TSH than anthropometric indicators in healthy subjects. A number of 78 euthyroid adults of both sexes were consecutively studied. R was the best single predictor of TSH (R-adj(2)=0.65, p<0.0001). It explained 36% more variance than bw (R-adj(2)=0.29, p<0.0001), the most accurate anthropometric predictor. Sex had no effect on the relationship between TSH, bioelectrical impedance analysis and anthropometry. After the contribution of R to TSH was taken into account, anthropometric indicators were not able to explain any additional part of TSH variance. We conclude that in healthy subjects, bioelectrical resistance is a better indicator of thyroid function than anthropometry, probably because of its more direct relationship with fat-free tissues. Further studies are needed to test whether this relationship holds in under- and over-weight subjects. (C) 2002, Editrice Kurtis.
• Structure and stereochemistry of reduction products of abietictype resin acids
  作者：Albert W. Burgstahler、John N. Marx、Duane F. Zinkel

  DOI：10.1021/jo01258a005

  日期：1969.6