(+/-)-Verbenon-epoxid | 24411-98-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (+/-)-Verbenon-epoxid
• 英文别名: Verbenonoxid；verbenone epoxide；2,3-epoxy-pinan-4-one；2,7,7-Trimethyl-3-oxatricyclo[4.1.1.0,2,4]octan-5-one；2,7,7-trimethyl-3-oxatricyclo[4.1.1.02,4]octan-5-one
• CAS: 24411-98-1；32578-99-7；33967-70-3
• 化学式: C₁₀H₁₄O₂
• 分子量: 166.22
• InChiKey: FAZVMCOEZIXWMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  29.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+/-)-Verbenon-epoxid 以 二氧化碳 、 水 、 异丙醇 为溶剂， 239.84 ℃ 、14.19 MPa 条件下， 以7.15%的产率得到2-hydroxy-6-isopropenyl-3-methylcyclohex-3-enone
  参考文献：
  名称：

  The thermolysis of α-pinene and verbenone epoxides in supercritical solvents

  摘要：

  Thermal transformations of alpha-pinene and verbenone epoxides were studied in supercritical solvents with complex compositions, including CO2, lower alcohols (ethanol and isopropanol), and water, over the temperature and pressure ranges 387-575 K and 135-215 atm. The main product from alpha-pinene epoxide in a supercritical solvent containing water was campholenic aldehyde and pinocamphone; the total content of these products in the reaction mixture was 80%. Suggestions concerning the mechanism of the thermal isomerization of alpha-pinene epoxide depending on the acidity of supercritical solvents were made. The direction of verbenone epoxide transformations was independent of the presence of water in the mixture. The main identified products were ketoalcohols with para-menthane and camphane frameworks.

  DOI：

  10.1134/s0036024410070058
• 作为产物：
  描述：

  马苄烯酮 在 双氧水 、 sodium hydroxide 作用下， 生成 (+/-)-Verbenon-epoxid
  参考文献：
  名称：

  The thermolysis of α-pinene and verbenone epoxides in supercritical solvents

  摘要：

  Thermal transformations of alpha-pinene and verbenone epoxides were studied in supercritical solvents with complex compositions, including CO2, lower alcohols (ethanol and isopropanol), and water, over the temperature and pressure ranges 387-575 K and 135-215 atm. The main product from alpha-pinene epoxide in a supercritical solvent containing water was campholenic aldehyde and pinocamphone; the total content of these products in the reaction mixture was 80%. Suggestions concerning the mechanism of the thermal isomerization of alpha-pinene epoxide depending on the acidity of supercritical solvents were made. The direction of verbenone epoxide transformations was independent of the presence of water in the mixture. The main identified products were ketoalcohols with para-menthane and camphane frameworks.

  DOI：

  10.1134/s0036024410070058

文献信息

• Agent for Treating Parkinson's Disease
  申请人：Salahutdinov Nariman Faridovich

  公开号：US20130116319A1

  公开（公告）日：2013-05-09

  The present invention relates to the use of 3-methyl-6-(1-methylethenyl)cyclohex-3-ene-1,2-diol, its isomers and derivatives, as a compound for Parkinson disease treatment, that can be used in medicine. The compound is highly active, low toxic and can be synthesized from available natural compound α-pinene.

  本发明涉及使用3-甲基-6-（1-甲基乙烯基）环己-3-烯-1,2-二醇及其异构体和衍生物作为帕金森病治疗的化合物，该化合物可以用于医学。该化合物活性高，毒性低，并可从可获得的天然化合物α-蒎烯合成。
• AGENT FOR TREATING PARKINSON'S DISEASE
  申请人：Obschestvo S Ogranichennoy Otvetstvennostyu "Tomskaya Farmatsevticheskaya Fabrika" (OOO "TFF")

  公开号：EP2517698B1

  公开（公告）日：2017-03-15
• Synthesis, catalytic oxidation and oxidative bromination reaction of a reusable polymer anchored oxovanadium(IV) complex
  作者：Sk. Manirul Islam、Anupam Singha Roy、Paramita Mondal、Noor Salam

  DOI：10.1016/j.molcata.2012.02.009

  日期：2012.6

  Polymer anchored oxovanadium catalyst was synthesized and characterized. The solid catalyst was characterized by Fourier transform infrared spectroscopy (FT-IR), UV-vis diffuse reflectance spectroscopy (DRS), thermogravimetric analysis (TGA) and scanning electron microscope (SEM). Its catalytic activity was evaluated for the oxidation of various alkenes, sulfides and aromatic alcohols with 30% H2O2 under mild reaction conditions. This catalyst was also effective for the oxidative bromination reaction of organic substrates with 80-100% selectivity of mono substituted products with H2O2/KBr at room temperature. The above reactions require minimum amount of H2O2, short time period and most importantly all the above reactions occur in aqueous medium. The developed catalyst can be facilely recovered and reused six times without significant decrease in activity and selectivity. This result confirms that the polymer anchored complex was not leached during the reaction, suggesting the true heterogeneous nature of the catalyst. (C) 2012 Elsevier B.V. All rights reserved.
• Fokin, A. A.; Butova, E. D.; Gulevich, A. V., Russian Journal of Organic Chemistry, 1993, vol. 29, # 5.2, p. 891 - 892
  作者：Fokin, A. A.、Butova, E. D.、Gulevich, A. V.、Yurchenko, A. G.、Krasutskii, P. A.

  DOI：——

  日期：——
• US8809391B2
  申请人：——

  公开号：US8809391B2

  公开（公告）日：2014-08-19