hexadecylmethylmalonyl chloride | 108269-94-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: hexadecylmethylmalonyl chloride
• 英文别名: hexadecylmethylmalonyl Dichloride；2-Hexadecyl-2-methylpropanedioyl dichloride
• CAS: 108269-94-9
• 化学式: C₂₀H₃₆Cl₂O₂
• 分子量: 379.411
• InChiKey: PRSHORQZWMIVJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.3
• 重原子数：
  24
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-羟甲基-12-冠-4 、 hexadecylmethylmalonyl chloride 在 吡啶 作用下， 以 苯 为溶剂， 反应 24.0h， 以62%的产率得到bis(1,4,7,10-tetraoxacyclododec-2-ylmethyl) 2-hexadecyl-2-methylpropanedioate
  参考文献：
  名称：

  Lithium-selective, lipophilic, small-ring bis(crown ethers)

  摘要：

  DOI：

  10.1021/jo00388a057
• 作为产物：
  描述：

  十六烷基丙二酸二乙酯 在 sodium hydroxide 、 草酰氯 、 四丁基氯化铵 作用下， 以 二氯甲烷 、 水 、 苯 为溶剂， 反应 25.0h， 生成 hexadecylmethylmalonyl chloride
  参考文献：
  名称：

  Lithium-selective, lipophilic, small-ring bis(crown ethers)

  摘要：

  DOI：

  10.1021/jo00388a057

文献信息

• Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
  申请人：The Clorox Company

  公开号：US06384279B1

  公开（公告）日：2002-05-07

  A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15H30N2O4 and is prepared by reacting a first quantity of 2-amino-2-methyl-1-propanol with a second quantity of a di-substituted malonyl dichloride (i.e., diethylmalonyl dichloride), preferably in ethyl acetate as solvent. A tetraamido macrocycle is prepared from the diamidodiol in two steps by oxidizing the diamidodiol to form a diacid followed by coupling using a known procedure of the diacid with an aryl diamine (e.g., 1,2-diaminobenzene) to yield the tetraamido macrocycle.

  一种新的二酰胺二醇物质及其制备方法。示例的二酰胺二醇的化学式为C15H30N2O4，通过将一定量的2-氨基-2-甲基-1-丙醇与二取代马来酰二氯化物（即二乙基马来酰二氯化物）在乙酸乙酯溶剂中反应制备而成。通过氧化二酰胺二醇形成二酸，然后使用已知的程序将二酸与芳香族二胺（例如1,2-二氨基苯）偶联，制备四酰胺大环。
• SYNTHESIS OF A TETRAAMIDO MACROCYCLE LIGAND FROM A NOVEL DIAMIDODIOL
  申请人：THE CLOROX COMPANY

  公开号：US20020028970A1

  公开（公告）日：2002-03-07

  A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C 15 H 30 N 2 O 4 and is prepared by reacting a first quantity of 2-amino-2-methyl-1-propanol with a second quantity of a di-substituted malonyl dichloride (i.e., diethylmalonyl dichloride), preferably in ethyl acetate as solvent. A tetraamido macrocycle is prepared from the diamidodiol in two steps by oxidizing the diamidodiol to form a diacid followed by coupling using a known procedure of the diacid with an aryl diamine (e.g., 1 ,2-diaminobenzene)to yield the tetraamido macrocycle.

  一种新的二酰胺二醇物质组合及其制备方法。示例的二酰胺二醇的化学式为C15H30N2O4，通过将第一量的2-氨基-2-甲基-1-丙醇与第二量的二取代马隆酰二氯化物（即二乙酰马隆酰二氯化物）在乙酸乙酯溶剂中反应制备而成。通过将二酰胺二醇氧化形成二酸，然后使用已知的方法将二酸与芳基二胺（例如1,2-二氨基苯）偶联，制备出四酰胺大环。
• PUGIA M. J.; KNUDSEN B. E.; BARTSCH R. A., J. ORG. CHEM., 52,(1987) N 12, 2617-2619
  作者：PUGIA M. J.、 KNUDSEN B. E.、 BARTSCH R. A.

  DOI：——

  日期：——
• [EN] IMPROVED SYNTHESIS OF A TETRAAMIDO MACROCYCLE LIGAND FROM A NOVEL DIAMIDODIOL<br/>[FR] SYNTHESE AMELIOREE D'UN LIGAND TETRA-AMIDO MACROCYCLIQUE A PARTIR D'UN NOUVEAU DIAMIDODIOL
  申请人：CLOROX CO

  公开号：WO2001002343A1

  公开（公告）日：2001-01-11

  A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15H30N2O4 and is prepared reacting a first quantity of 2-amino-2-methyl-1-propanol with a second quantity of a disubstituted malonyl dichloride (i.e., diethylmalonyl dichloride), preferably in ethyl acetate as solvent. A tetraamido macrocylce is prepared from the diamidodiol in two steps by oxidizing the diamidodiol to form a diacid followed by coupling using a known procedure of the diacid with an aryl diamine (e.g., 1,2-diaminobenzene) to yield the tetraamido macrocylcle.