8-[(2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolan-2-yl]-2,4-dimethoxyquinazoline | 1262431-79-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8-[(2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolan-2-yl]-2,4-dimethoxyquinazoline
• 英文别名: 8-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-2,4-dimethoxyquinazoline；8-[(2S,3S,4R,5R)-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolan-2-yl]-2,4-dimethoxyquinazoline
• CAS: 1262431-79-7
• 化学式: C₃₆H₃₆N₂O₆
• 分子量: 592.692
• InChiKey: OTQFDURHCIDODY-SCXNRCNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  44
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  81.2
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  8-[(2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolan-2-yl]-2,4-dimethoxyquinazoline 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以79%的产率得到8-(β-D-ribofuranosyl)-2,4-dimethoxyquinazoline
  参考文献：
  名称：

  The Components of xRNA: Synthesis and Fluorescence of a Full Genetic Set of Size-Expanded Ribonucleosides

  摘要：

  The synthesis and properties of a full set of four benzo-expanded ribonucleosides (xRNA), analogous to A, G, C, and U RNA monomers, are described. The nucleosides are efficient fluorophores with emission maxima of 369-411 nm. The compounds are expected to be useful as RNA pathway probes and as components of an unnatural ribopolymer.

  DOI：

  10.1021/ol102915f
• 作为产物：
  描述：

  2,6-二溴苯胺 在 叔丁基锂 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 N,N-二乙基苯胺 、 三氯氧磷 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 、 甲醇 、 N,N-二甲基甲酰胺 、 正戊烷 为溶剂， 反应 44.33h， 生成 8-[(2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolan-2-yl]-2,4-dimethoxyquinazoline
  参考文献：
  名称：

  The Components of xRNA: Synthesis and Fluorescence of a Full Genetic Set of Size-Expanded Ribonucleosides

  摘要：

  The synthesis and properties of a full set of four benzo-expanded ribonucleosides (xRNA), analogous to A, G, C, and U RNA monomers, are described. The nucleosides are efficient fluorophores with emission maxima of 369-411 nm. The compounds are expected to be useful as RNA pathway probes and as components of an unnatural ribopolymer.

  DOI：

  10.1021/ol102915f

文献信息

• [EN] CD73 INHIBITORS<br/>[FR] INHIBITEURS DE CD73
  申请人：BIOARDIS LLC

  公开号：WO2020211668A1

  公开（公告）日：2020-10-22

  Disclosed are compounds that are inhibitors of CD73 and are useful in treating CD73-associated diseases or conditions, and compositions containing the compounds.

  本文披露了一种抑制CD73的化合物，可用于治疗与CD73相关的疾病或症状，以及含有这些化合物的组合物。
• CD73 INHIBITORS
  申请人：BioArdis LLC

  公开号：US20220185832A1

  公开（公告）日：2022-06-16

  Disclosed are compounds that arc inhibitors of CD73 and arc useful in treating CD73-associated diseases or conditions, and compositions containing the compounds.
• [EN] QUINAZOLINE DERIVATIVES AS CD73 INHIBITORS<br/>[FR] DÉRIVÉS DE QUINAZOLINE EN TANT QU'INHIBITEURS DE CD73
  申请人：BIOARDIS LLC

  公开号：WO2020210938A1

  公开（公告）日：2020-10-22

  Provided are quinazoline derivatives that are inhibitors of CD73 and are useful in treating CD73-associated diseases or conditions. Provided are also compositions containing the compounds.
• The Components of xRNA: Synthesis and Fluorescence of a Full Genetic Set of Size-Expanded Ribonucleosides
  作者：Armando R. Hernández、Eric T. Kool

  DOI：10.1021/ol102915f

  日期：2011.2.18

  The synthesis and properties of a full set of four benzo-expanded ribonucleosides (xRNA), analogous to A, G, C, and U RNA monomers, are described. The nucleosides are efficient fluorophores with emission maxima of 369-411 nm. The compounds are expected to be useful as RNA pathway probes and as components of an unnatural ribopolymer.