2,2'-[(4-氟-3-硝基苯基)亚氨基]双乙醇 | 29705-38-2

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,2'-[(4-氟-3-硝基苯基)亚氨基]双乙醇
• 英文名称: 4-Fluor-3-nitro-N,N-bis-β-hydroxyethylanilin
• 英文别名: 4-Fluor-N,N-bis-(2-hydroxy-ethyl)-3-nitro-anilin；2,2'-[(4-fluoro-3-nitrophenyl)imino]bisethanol；2-fluoro-5-bis(β-hydroxyethyl)amino-1-nitrobenzene；N,N-bis(2-hydroxyethyl)-4fluoro-3-nitroaniline；2-((4-fluoro-3-nitrophenyl)(2-hydroxyethyl)amino)ethanol；4-fluoro-3-nitro-N,N,-bis(2-hydroxyethyl)-aminobenzene；4-fluoro-3-nitro-N,N-di-(2-hydroxyethyl)-aniline；Ethanol, 2,2'-[(4-fluoro-3-nitrophenyl)imino]bis-；2-[4-fluoro-N-(2-hydroxyethyl)-3-nitroanilino]ethanol
• CAS: 29705-38-2
• 化学式: C₁₀H₁₃FN₂O₄
• 分子量: 244.223
• InChiKey: ZZJIOLHDWAXCSE-UHFFFAOYSA-N

物化性质

• 沸点：
  454.6±45.0 °C(Predicted)
• 密度：
  1.424±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  89.5
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 海关编码：
  2922199090
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

反应信息

• 作为反应物：
  描述：

  2,2'-[(4-氟-3-硝基苯基)亚氨基]双乙醇 在 氢气 作用下， 以 乙醇 、 水 为溶剂， 23.0~70.0 ℃ 、413.7 kPa 条件下， 反应 11.5h， 生成 4-[6-[bis(2-hydroxyethyl)amino]-2-hydroxy-3-methyl-1H-benzimidazol-2-yl]butanoic acid
  参考文献：
  名称：

  [EN] PROCESS FOR MAKING BENDAMUSTINE
  [FR] PROCÉDÉ DE FABRICATION DE BENDAMUSTINE

  摘要：

  本发明涉及一种新的工艺和中间体，用于制备药用产品苯达莫司汀（Bendamustine）的公式（1）或其药用可接受盐，其中该工艺基于使用公式（13）化合物作为起始物质。

  公开号：

  WO2013150020A1

文献信息

• Hair dye preparations containing nitrodiphenylamine derivative
  申请人：Henkel Kommanditgesellschaft auf Aktien

  公开号：US04859206A1

  公开（公告）日：1989-08-22

  This invention encompasses compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 independently are hydrogen, C.sub.1-4 alkyl, or C.sub.2-4 hydroxyalkyl; one of R.sup.3 to R.sup.7 is --SO.sub.3 H or --COOH; and the remaining of R.sup.3 to R.sup.7 independently are hydrogen, chlorine, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, or --NR.sup.8 R.sup.9, where R.sup.8 and R.sup.9 independently are hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkoxy, or where --NR.sup.8 R.sup.9 is piperidine, morpholine, piperazine, or pyrrolidone; or a water soluble salt thereof; hair dye preparation containing these compounds, and methods for dyeing hair using such preparation.

  这项发明涵盖了以下结构的化合物 ##STR1## 其中 R.sup.1 和 R.sup.2 独立地是氢、C.sub.1-4 烷基或 C.sub.2-4 羟基烷基；R.sup.3 到 R.sup.7 中的一个是 --SO.sub.3 H 或 --COOH；而剩余的 R.sup.3 到 R.sup.7 独立地是氢、氯、C.sub.1-4 烷基、C.sub.1-4 烷氧基，或 --NR.sup.8 R.sup.9，其中 R.sup.8 和 R.sup.9 独立地是氢、C.sub.1-4 烷基、C.sub.2-4 烷氧基，或者 --NR.sup.8 R.sup.9 是哌啶、吗啉、哌嗪或吡咯烷；或其水溶性盐；含有这些化合物的染发制剂；以及使用该制剂染发的方法。
• Cationic monobenzene nitrophenylenediamines, their use in dyeing keratinous fibers, dyeing compositions comprising them and dyeing processes
  申请人：L'Oreal S.A.

  公开号：US06464731B1

  公开（公告）日：2002-10-15

  The subject of the invention is cationic monobenzene nitrophenylenediamines having at least one cationic charge delocalized over an unsaturated 5-membered polynitrogenous heterocycle, to their use as direct dye in dyeing compositions for keratinous substances, in particular for human keratinous fibers, such as the hair, to the dyeing compositions comprising them and to the dyeing processes employing these compositions.

  本发明的主题是具有至少一个阳离子电荷的对苯二胺类单阳离子硝基苯胺，其电荷在不饱和的5元杂氮杂环上离域，以及它们在染料组合物中作为直接染料用于染色角蛋白物质，特别是用于人类角蛋白纤维，如头发，以及包含它们的染色组合物和使用这些组合物的染色过程。
• OXIDATION DYES
  申请人：Andreas J. Bittner

  公开号：US20010005914A1

  公开（公告）日：2001-07-05

  The invention relates to oxidation colorants which are particularly suitable for coloring keratin fiber and to a method of coloring such fiber. The colorants contain as the preliminary oxidation dye at least one diamino aniline of the general formula (I), in which R 1 to R 6 independently of each other are hydrogen, a (C 1- C 4 )-alkyl group, a hydroxy-(C 2- C 3 )-alkyl group, a (C 1- C 4 )-alkoxy-(C 2- C 3 )-alkyl group, an amino-(C 2- C 3 )-alkyl group in which the amino group can also have one or two (C 1- C 4 )-alkyl radicals, or a 2,3-dihydroxypropyl group provided that not all substituents R 1 to R 6 are simultaneously hydrogen, and R 1 and R 2 and/or R 3 and R 4 and/or R 5 and R 6 along with the nitrogen atom to which they are attached are also an aziridine ring, an azetidine ring, a pyrrolidine ring, a piperidine ring, an azepane ring, an azocine ring or a morpholino group, thiomorpholino group or piperazino group which has another substituent R 7 on the nitrogen atom which is selected from hydrogen, a (C 1- C 4 )-alkyl group, a hydroxy-(C 2- C 3 )-alkyl group, a (C 1- C 4 )-alkoxy-(C 2- C 3 )-alkyl group, an amino-(C 2- C 3 )-alkyl group, or a 2,3-dihydroxypropyl group, and the three remaining hydrogen atoms on the benzol ring can also be replaced independently of each other by a halogen atom or a (C 1- C 4 )-alkyl group, or the physiologically tolerable salts thereof with inorganic and organic acids. Shades of color are obtained which have a high level of brilliancy and color fastness.

  该发明涉及氧化着色剂，特别适用于着色角蛋白纤维，并提供了一种着色这种纤维的方法。这些着色剂包含至少一种二氨基苯胺的初级氧化染料，其通式为（I），其中R1到R6独立地是氢，（C1-C4）烷基，羟基（C2-C3）烷基，（C1-C4）烷氧基（C2-C3）烷基，氨基（C2-C3）烷基，其中氨基团也可以有一个或两个（C1-C4）烷基基团，或2,3-二羟基丙基基团，前提是R1到R6的所有取代基不同时是氢，且R1和R2和/或R3和R4和/或R5和R6连同它们连接的氮原子也是氮杂环丙烷环，氮杂环丁烷环，吡咯烷环，哌啶环，氮杂庚烷环，氮杂环庚烷环或吗啉基，硫代吗啉基或哌嗪基，其在氮原子上还有另一个取代基R7，选自氢，（C1-C4）烷基，羟基（C2-C3）烷基，（C1-C4）烷氧基（C2-C3）烷基，氨基（C2-C3）烷基，或2,3-二羟基丙基基团，苯环上的其余三个氢原子也可以独立地被卤原子或（C1-C4）烷基取代，或其与无机和有机酸的生理耐受盐。获得的色彩具有高度的光泽度和色牢度。
• [EN] NOVEL THERAPEUTIC AGENTS<br/>[FR] NOUVEAUX AGENTS THÉRAPEUTIQUES
  申请人：EURO CELTIQUE

  公开号：WO2013113838A1

  公开（公告）日：2013-08-08

  The present invention relates to a class of hydroxamic acid compounds of Formula (I), which act as alkylating agents and/or inhibitors of the HDAC pathway, having potential utility in the treatment of a neoplastic disease and immune diseases.

  本发明涉及一类具有式(I)的羟肟酸化合物，它们作为烷基化剂和/或HDAC途径抑制剂，具有在治疗肿瘤性疾病和免疫性疾病方面的潜在用途。
• Aromatic allylaminonitro compounds, hair dye compositions containing
  申请人：Henkel Kommanditgesellschaft auf Aktien

  公开号：US05685881A1

  公开（公告）日：1997-11-11

  Aromatic allylaminonitro compounds corresponding to formula (I): ##STR1## in which R.sup.1 is hydrogen or an alkyl group containing 1 to 4 carbon atoms, R.sup.2 is hydrogen, an alkyl group containing 1 to 4 carbon atoms or an allyl group CH.sub.2 C(R.sup.5)=CH.sub.2, where R.sup.5 is hydrogen or an alkyl group containing 1 to 4 carbon atoms, R.sup.3 is carboxyl, hydroxy, nitro, halogen or a group NR.sup.6 R.sup.7, where R.sup.6 and R.sup.7 independently of one another represent hydrogen, an alkyl group containing 1 to 4 carbon atoms, a hydroxyalkyl or dihydroxyalkyl group containing 2 to 4 carbon atoms or an allyl group CH.sub.2 C(R.sup.8)=CH.sub.2, where R.sup.8 is hydrogen or an alkyl group containing 1 to 4 carbon atoms, and R.sup.4 is hydrogen or nitro, with the proviso that R.sup.3 and R.sup.4 are not both nitro. The compounds are useful for dyeing fibers, particularly human hair.

  化合物对应于公式（I）的芳香族烯丙基氨基硝基化合物：##STR1## 其中R.sup.1是氢或含有1至4个碳原子的烷基基团，R.sup.2是氢，含有1至4个碳原子的烷基基团或烯丙基基团CH.sub.2 C(R.sup.5)=CH.sub.2，其中R.sup.5是氢或含有1至4个碳原子的烷基基团，R.sup.3是羧基，羟基，硝基，卤素或基团NR.sup.6 R.sup.7，其中R.sup.6和R.sup.7独立地表示氢，含有1至4个碳原子的烷基基团，含有2至4个碳原子的羟基烷基或二羟基烷基基团或烯丙基基团CH.sub.2 C(R.sup.8)=CH.sub.2，其中R.sup.8是氢或含有1至4个碳原子的烷基基团，R.sup.4是氢或硝基，但R.sup.3和R.sup.4不能同时为硝基。这些化合物可用于染色纤维，尤其是人类头发。