氨三乙酰胺 | 4862-18-4

• 物质功能分类: 有机原料 - 氨基化合物 - 酰胺类化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 氨三乙酰胺
• 英文名称: nitrilotriacetic acid triamide
• 英文别名: nitrilotriacetamide；tris-acetamide；nitrilotri-acetic acid triamide；ntam；Nitrilotri-essigsaeure-triamid；Triglykolamidsaeure-triamid；2-[bis(2-amino-2-oxoethyl)amino]acetamide
• CAS: 4862-18-4
• 化学式: C₆H₁₂N₄O₃
• 分子量: 188.186
• InChiKey: CVTGEDNIBVTKBJ-UHFFFAOYSA-N

物化性质

• 熔点：
  206-209 °C (decomp)
• 沸点：
  577.3±45.0 °C(Predicted)
• 密度：
  1.371±0.06 g/cm3(Predicted)
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  133
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  氨三乙酰胺 在 硫酸 作用下， 以 水 为溶剂， 反应 12.0h， 生成 N-methylnitrilotriacetamide
  参考文献：
  名称：

  Facile synthesis of substituted nitrilotriacetamides

  摘要：

  Ligands which contain multiple amide groups represent interesting possibilities as chelating agents. We report here a facile synthesis and crystal structure of nitrilotriacetamide, 2, a neutral tetradentate ligand which we have been studying for metal complexation. Also described herein is a divergent synthesis of the mono, di- and trimethylated and dimethyl-monoalkyl derivatives of 2.

  DOI：

  10.1016/0040-4039(93)88040-p
• 作为产物：
  描述：

  氯乙酰胺 在 乙醇 、 氨 作用下， 生成 氨三乙酰胺
  参考文献：
  名称：

  Ueber einige Guanidinderivate

  摘要：

  DOI：

  10.1002/ardp.19092470328

文献信息

• Characterization of [Pb(NO3)(ntam)2]NO3, the first metal complex of the neutral tetradentate ligand nitrilotriacetamide (ntam)
  作者：Douglas A. Smith、Steven Sucheck、A. Alan Pinkerton

  DOI：10.1039/c39920000367

  日期：——

  The first isolable, crystalline complex of nitrilotriacetamide with a metal and the first example of both a completely acyclic ligand and a 2 : 1 ligand: metal ratio in a ten-coordinate lead complex is reported.

  本研究首次报道了硝基三乙酰胺与金属的可分离结晶络合物，也首次报道了十配位铅络合物中完全无环配体和配体与金属比例为 2 : 1 的实例。
• The amide oxygen donor. Metal ion coordinating properties of the ligand nitrilotriacetamide. A thermodynamic and crystallographic study
  作者：Laura A. Clapp、Chynthia J. Siddons、Donald G. VanDerveer、Joseph H. Reibenspies、S. Bart Jones、Robert D. Hancock

  DOI：10.1039/b512017a

  日期：——

  of [Pb(ntam)(NO3)2]2 (1) and [Ca2(ntam)3(H2O)2](ClO4)4·3H2O (2) are reported. For 1: triclinic, space group P, a = 7.4411(16), b = 9.0455(19), c = 11.625(3) Å, α = 69.976(4), β = 79.591(4), γ = 67.045(3)°, Z = 2, R = 0.0275. For 2: monoclinic, space group P21/c, a = 10.485(2), b = 11.414(2), c = 38.059(8) Å, β = 92.05(3)°, Z = 4, R = 0.0634. Structure 1 is dimeric with two Pb atoms linked by bridging

  ntam（次氮基三乙酰胺）的报告。在25°C下于0.1 M NaClO 4中，ntam的质子化常数（p K）为2.6 。在25°C下于0.1 M NaClO 4中的形成常数（log K 1）由下式确定：1 H NMR 和 紫外可见 光谱学分别为：Ca（II），1.28；镁（II），0.4；La（III），2.30；铅（II），3.69。Cd（II），3.78； m / z。Ni（II），2.38； N，2。铜（II），3.16。讨论了ntam配合物的实测log K 1值，如p K所证明的那样，是因为N供体的碱度较低，以及金属离子尺寸对配合物稳定性的影响。这酰胺相对于NH 3络合物的log K 1，ntam的O供体导致大型金属离子（Pb（II），Cd（II），La（III），Ca（II））的络合物的稳定化，而对于较小的金属离子金属离子（Ni（II），Cu（II））酰胺O型供体会导致不稳定。就
• Process for producing glycine
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP1770169A1

  公开（公告）日：2007-04-04

  A method for producing glycine in which an aqueous solution of glycinonitrile is subjected to a hydrolysis reaction in a hydrolysis reaction system in which the oxygen dissolved therein is maintained in an amount of 5 ppm by weight or less, under the action of a microbial enzyme having the activity to hydrolyze a nitrile group. The glycinonitrile is converted to glycine with by-production of ammonia. The hydrolysis of glycinonitrile is conducted either in the presence of the ammonia or while recovering the by-produced ammonia separately from the recovery of glycine in the absence of a base and an acid.

  一种生产甘氨酸的方法，在该方法中，在具有水解腈基活性的微生物酶的作用下，将甘腈水溶液在水解反应系统中进行水解反应，在该系统中，溶解在其中的氧气量按重量计保持在百万分之五或更低。甘氨腈转化为甘氨酸，同时产生氨。甘氨腈的水解可以在有氨存在的情况下进行，也可以在没有碱和酸的情况下将副产的氨与甘氨酸的回收分开进行。
• Method of monitoring fluid flow from a reservoir using well treatment agents
  申请人：Baker Hughes Incorporated

  公开号：US10641083B2

  公开（公告）日：2020-05-05

  A method of treating a multi-zoned subterranean formation with composites having well treatment agents is disclosed. The well treatment agent treated in each zone is distinguishable. At least a portion of the well treatment agent is released from one of the composites into the well or formation. The formation of undesirable contaminants may be inhibited or prevented in the well or in the formation by the release of the well treatment agent from one or more of the composites. The well treatment agent also serves as a tracer. When fluid transported from the formation or well is collected, the source of the transported fluid may be determined by comparing a chemical or physical parameter of the well treatment agent with a working set of known taggants.

  本发明公开了一种用含有油井处理剂的复合材料处理多分区地下地层的方法。在每个区域处理的井处理剂是可区分的。至少有一部分油井处理剂从其中一种复合材料中释放到油井或地层中。通过从一种或多种复合材料中释放油井处理剂，可抑制或防止油井或地层中形成不良污染物。油井处理剂还可用作示踪剂。当收集到从地层或油井中运出的流体时，可通过比较油井处理剂的化学或物理参数与已知标记物的工作集来确定运出流体的来源。
• Detection of trace chemicals in oil and gas applications
  申请人：Murugesan Sankaran

  公开号：US10739269B2

  公开（公告）日：2020-08-11

  A method of analyzing a well sample for a well treatment additive includes contacting the sample with functionalized metallic nanoparticles that contain metallic nanoparticles functionalized with a functional group including a cyano group, a thiol group, a carboxyl group, an amino group, a boronic acid group, an aza group, an ether group, a hydroxyl group, or a combination including at least one of the foregoing; irradiating the sample contacted with the functionalized metallic nanoparticles with electromagnetic radiation at a selected energy level; measuring a Raman spectrum emitted from the sample; and determining presence, type or concentration of the well treatment additive in the sample from the Raman spectrum.

  一种分析油井样品中油井处理添加剂的方法包括：将样品与功能化金属纳米粒子接触，该纳米粒子含有被官能团官能化的金属纳米粒子，官能团包括氰基、硫醇基、羧基、氨基、硼酸基、氮基、醚基、羟基或包括上述至少一种官能团的组合；用选定能级的电磁辐射照射与官能化金属纳米颗粒接触的样品；测量样品发射的拉曼光谱；以及根据拉曼光谱确定样品中是否存在井处理添加剂、添加剂的类型或浓度。