烯丙基-喹啉-4-基-胺 | 14164-96-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 烯丙基-喹啉-4-基-胺
• 英文名称: allyl-quinolin-4-yl-amine
• 英文别名: N-prop-2-enylquinolin-4-amine
• CAS: 14164-96-6
• 化学式: C₁₂H₁₂N₂
• 分子量: 184.241
• InChiKey: UEVDMTQQOIQCEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  烯丙基-喹啉-4-基-胺 在 palladium on activated charcoal 甲烷磺酸 作用下， 以 乙醇 为溶剂， 以94%的产率得到4-氨基喹啉
  参考文献：
  名称：

  Allyl amines as ammonia equivalents in the preparation of anilines and heteroarylamines

  摘要：

  A series of anilines and heteroarylamines were synthesized in moderate to excellent yields by palladium catalyzed cross coupling reaction of aryl or heteroaryl halides with allyl-or N,N-diallylamine followed by deallylation. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10877-2
• 作为产物：
  描述：

  4-氯喹啉 、 丙烯胺 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 1,1'-双(二苯基膦)二茂铁 、 sodium t-butanolate 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以45%的产率得到烯丙基-喹啉-4-基-胺
  参考文献：
  名称：

  Allyl amines as ammonia equivalents in the preparation of anilines and heteroarylamines

  摘要：

  A series of anilines and heteroarylamines were synthesized in moderate to excellent yields by palladium catalyzed cross coupling reaction of aryl or heteroaryl halides with allyl-or N,N-diallylamine followed by deallylation. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10877-2

文献信息

• Process for the production of quinoline containing heterocycles, intermediates, and process for the production of the intermediates
  申请人：FISONS plc

  公开号：EP0077090A1

  公开（公告）日：1983-04-20

  There is described a process for the production of a compound of formula 1, in which R is hydrogen or alkyl CI to 6, and R5 and R10, which may be the same or different, are each hydrogen or alkyl CI to 6, or a pharmaceutically acceptable derivative thereof, which comprises removal of an activating group from a compound of formula II, or a suitable derivative thereof, in which R, R5 and R,o are as defined above, and X represents an activating group, and if desired or necessary converting the resulting compound of formula I to a pharmaceutically acceptable derivative thereof, or vice versa. There is also described a process for the production of a compound of formula II in which R is hydrogen, or a suitable derivative thereof, which comprises reaction of a compound of formula III, or a suitable derivative thereof, in which R5 and R10 are as defined above, with a compound of formula IV, in which X is as defined above.

  这里介绍一种生产式 1 化合物的工艺、 其中 R 是氢或 CI-6 烷基，R5 和 R10（可以相同或不同）各自是氢或 CI-6 烷基，或其药学上可接受的衍生物，该工艺包括从式 II.或其适当衍生物中去除活化基团，其中 R、R5 和 R,o 如上文所定义，X 代表活化基团、 或其适当的衍生物，其中 R、R5 和 R,o 如上文所定义，X 代表活化基团，如果需要或必要，将得到的式 I 化合物转化为其药学上可接受的衍生物，反之亦然。 还描述了一种生产式 II 化合物（其中 R 为氢）或其适当衍生物的工艺，该工艺包括式 III、 或其适当衍生物（其中 R5 和 R10 如上文所定义）与式 IV 的化合物反应、 其中 X 如上所定义。
• Small molecule immunopotentiators and assays for their detection
  申请人：Novartis Vaccines and Diagnostics, Inc.

  公开号：EP2583678A2

  公开（公告）日：2013-04-24

  The invention provides immunostimulatory compositions comprising a small molecule immuno-potentiator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma. In a further aspect, the invention relates generally to methods of screening for small molecule immuno-modulatory compositions.

  本发明提供了包含小分子免疫促进剂（SMIP）化合物的免疫刺激组合物及其施用方法。还提供了施用有效量的 SMIP 化合物以增强受试者对抗原的免疫应答的方法。本发明还提供了单独施用 SMIP 化合物或与另一种制剂联合施用 SMIP 化合物以治疗癌症、传染性疾病和/或过敏/哮喘的新型组合物和方法。在另一方面，本发明一般涉及筛选小分子免疫调节组合物的方法。
• ELECTROCONDUCTIVE COMPOSITION, ELECTRICAL CONDUCTOR, LAMINATE AND METHOD FOR PRODUCING SAME, ELECTROCONDUCTIVE FILM, AND SOLID ELECTROLYTE CONDENSER
  申请人：MITSUBISHI RAYON CO., LTD.

  公开号：US20160093413A1

  公开（公告）日：2016-03-31

  The electroconductive composition of the present invention contains an electroconductive polymer (A) having a sulfonic acid group and/or carboxylic acid group, and a basic compound (B) having two or more nitrogen atoms. The electrical conductor of the present invention consists of the electroconductive composition. In the laminate of the present invention, the electrical conductor is laminated on at least one surface of a substrate. The method for producing a laminate of the present invention includes applying the electroconductive composition to at least one surface of a substrate, heating and drying the composition, and forming an electrical conductor. The electroconductive film of the present invention is provided with the electrical conductor. The solid electrolyte condenser of the present invention is provided with a positive electrode consisting of a porous body of a valve metal, a dielectric layer formed by oxidizing the positive electrode surface, and one or more solid electrolyte layers formed on the dielectric layer surface side, and at least one of the solid electrolyte layers is formed of the electroconductive composition.
• US4471119A
  申请人：——

  公开号：US4471119A

  公开（公告）日：1984-09-11
• US4614802A
  申请人：——

  公开号：US4614802A

  公开（公告）日：1986-09-30