8β-pimaran-18-oic acid | 7715-72-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 8β-pimaran-18-oic acid
• 英文别名: Pimaran-18-oic acid；pimarenic acid；(13R)-pimaran-18-oic acid；(13R)-Pimaran-18-saeure；(13R)-Pimaransaeure-(18)；1.7.12-Trimethyl-7-aethyl-tetradekahydrophenanthren-carbonsaeure-(1)；(1R,4aR,4bS,7R,8aS,10aR)-7-ethyl-1,4a,7-trimethyl-3,4,4b,5,6,8,8a,9,10,10a-decahydro-2H-phenanthrene-1-carboxylic acid
• CAS: 7715-72-2
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.489
• InChiKey: UPTDGYZWMBPKCL-MYOQPVCSSA-N

物化性质

• 熔点：
  236-237 °C
• 沸点：
  414.3±13.0 °C(Predicted)
• 密度：
  0.982±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8β-pimaran-18-oic acid 在 sodium acetate 、 二氧化氮 作用下， 以 二氯甲烷 为溶剂， 生成 N-Nitroso-N-methyl-8β-pimaran-18-amid
  参考文献：
  名称：

  Photolysis of a medium-ring nitrosamide

  摘要：

  DOI：

  10.1139/v67-209
• 作为产物：
  描述：

  8-pimarenic acid 在 溶剂黄146 、 铂 作用下， 生成 8β-pimaran-18-oic acid
  参考文献：
  名称：

  Clinico-pathological profile of pediatric lymphadenopathy

  摘要：

  Objective: To study the clinico-pathological profile of significant pediatric peripheral lymphadenopathy and to arrrive at an etiological diagnosis. Methods: Prospective study in a tertiary care hospital setting. One hundred consecutive children reporting to pediatric OPD from 1 January 1995 to 31 December 1998, aged 1 month to 12 years were studied. Results: The commonest aetiology diagnosed was tubercular lymphadenitis in 35% cases, followed by chronic tonsillopharyngitis in 15% cases. Lymphomas, AIDS and infectious mononucleosis constituted 3, 2 and 1 cases each. Aetiology could not be ascertained in 44 (44%) children even after detailed haematological, microbiological, radiological and serological investigations. FNAC's sensitivity and specificity as compared to 'gold standard of excision lymph node biopsy was 94% and 100% respectively. Conclusion: Tubercular lymphadenitis was the commonest treatable entity of significant pediatric peripheral lymphadenopathy. A majority of the cases even after thorough evaluation, remained undiagnosed. FNAC as a diagnostic modality is almost as sensitive and as specific as excision lymph node biopsy when an adequate aspirate is examined by expert eyes.

  DOI：

  10.1007/bf02724385

文献信息

• Ruzicka; Huyser; Seidel, Recueil des Travaux Chimiques des Pays-Bas, 1928, vol. 47, p. 366
  作者：Ruzicka、Huyser、Seidel

  DOI：——

  日期：——
• US5248696A
  申请人：——

  公开号：US5248696A

  公开（公告）日：1993-09-28
• [EN] COMPOSITION AND METHOD FOR TREATING TUMORS
  申请人：WORLD RESEARCH INSTITUTE FOR SCIENCE AND TECHNOLOGY, INC.

  公开号：WO1992018119A1

  公开（公告）日：1992-10-29

  (EN) A composition and method for treating tumors with resin acids and derivatives thereof are provided.(FR) Composition et méthode de traitement de tumeurs à l'aide d'acides résiniques et de dérivés desdits acides.
• Clinico-pathological profile of pediatric lymphadenopathy
  作者：M. Pradeep Reddy、Nekhil Moorchung、Arun Chaudhary

  DOI：10.1007/bf02724385

  日期：2002.12

  Objective: To study the clinico-pathological profile of significant pediatric peripheral lymphadenopathy and to arrrive at an etiological diagnosis. Methods: Prospective study in a tertiary care hospital setting. One hundred consecutive children reporting to pediatric OPD from 1 January 1995 to 31 December 1998, aged 1 month to 12 years were studied. Results: The commonest aetiology diagnosed was tubercular lymphadenitis in 35% cases, followed by chronic tonsillopharyngitis in 15% cases. Lymphomas, AIDS and infectious mononucleosis constituted 3, 2 and 1 cases each. Aetiology could not be ascertained in 44 (44%) children even after detailed haematological, microbiological, radiological and serological investigations. FNAC's sensitivity and specificity as compared to 'gold standard of excision lymph node biopsy was 94% and 100% respectively. Conclusion: Tubercular lymphadenitis was the commonest treatable entity of significant pediatric peripheral lymphadenopathy. A majority of the cases even after thorough evaluation, remained undiagnosed. FNAC as a diagnostic modality is almost as sensitive and as specific as excision lymph node biopsy when an adequate aspirate is examined by expert eyes.
• Photolysis of a medium-ring nitrosamide
  作者：O. E. Edwards、R. S. Rosich

  DOI：10.1139/v67-209

  日期：1967.6.1