[3-O-benzyl-4-O-(4-methoxybenzyl)-α-L-idopyranosyluronic acid]-(1->3)-(2-acetamido-6-O-benzyl-2-deoxy-4-O-pivaloyl-β-D-galactopyranosyl)-(1->4)-methyl 3-O-benzyl-α-L-idopyranosiduronic acid | 445397-74-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [3-O-benzyl-4-O-(4-methoxybenzyl)-α-L-idopyranosyluronic acid]-(1->3)-(2-acetamido-6-O-benzyl-2-deoxy-4-O-pivaloyl-β-D-galactopyranosyl)-(1->4)-methyl 3-O-benzyl-α-L-idopyranosiduronic acid
• CAS: 445397-74-0
• 化学式: C₅₅H₆₇NO₂₀
• 分子量: 1062.13
• InChiKey: SZHGNDVAPXTBBW-OXCFPTETSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.91
• 重原子数：
  76.0
• 可旋转键数：
  23.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  271.99
• 氢给体数：
  5.0
• 氢受体数：
  18.0

反应信息

• 作为反应物：
  描述：

  [3-O-benzyl-4-O-(4-methoxybenzyl)-α-L-idopyranosyluronic acid]-(1->3)-(2-acetamido-6-O-benzyl-2-deoxy-4-O-pivaloyl-β-D-galactopyranosyl)-(1->4)-methyl 3-O-benzyl-α-L-idopyranosiduronic acid 在 三甲基氨基磺酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 以63%的产率得到sodium O-[sodium 3-O-benzyl-4-O-(4-methoxybenzyl)-2-O-sodium sulfonato-α-L-idopyranosyluronate]-(1->3)-(2-acetamido-6-O-benzyl-2-deoxy-4-O-pivaloyl-β-D-galactopyranosyl)-(1->4)-(methyl 3-O-benzyl-2-O-sodium sulfonato-α-L-idopyranosid)uronate
  参考文献：
  名称：

  An access to various sulfation patterns in dermatan sulfate: chemical syntheses of sulfoforms of trisaccharide methyl glycosides

  摘要：

  The syntheses are reported for the first time of alpha-L-IdopA(2)SO(3)-(1-->3)-beta-D-GalpNAc4SO(3)-(1-->4)-alpha-L-IdopA2SO(3)-(1-->OMe), its disulfated analogue alpha-L-IdopA2SO(3)-(1-->3)-beta-D-GalpNAc4SO(3)-(1-->4)-alpha-L-IdopA2SO(3)-(1-->OMe), and of beta-D-GalpNAc4SO(3)-(1-->4)-alpha-L-IdopA2SO(3)-(1-->3)-beta-D-GalpNAc4SO(3)-(1-->OMe), which represent structural fragments of dermatan sulfate, unavailable directly by chemical or enzymatic degradation of the glycosaminoglycan polymer. These molecules were readily obtained from a pair of key disaccharide intermediates, in which the relative difference of stability of the D-GalNAc 4-hydroxy protecting groups (acetate or pivalate) toward saponification conditions allowed access to various sulfoforms from a common precursor. For the preparation of these blocks, the 4-O-pivaloyl-D-galacto moiety was readily obtained through a one-pot stereospecific intramolecular nucleophilic displacement on an easily available 3-O-pivaloyl-D-gluco precursor,and the L-IdoA moiety through selective radical oxidation at C-6 of a L-ido 4,6-diol derivative with oxoammonium salts. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(02)00060-5
• 作为产物：
  描述：

  4-methoxyphenyl 4,6-O-benzylidene-2-deoxy-2-trochloroacetamido-β-D-glucopyranoside 在 potassium bromide 吡啶 、 三乙基硅烷 、 4-二甲氨基吡啶 、 2,2,6,6-tetramethyl-piperidine-N-oxyl 、 lithium hydroxide 、 sodium hydroxide 、 calcium hypochlorite 、 ammonium cerium(IV) nitrate 、 偶氮二异丁腈 、 三氟甲磺酸酐 、 三氟甲磺酸三甲基硅酯 、 双氧水 、 三正丁基氢锡 、 碳酸氢钠 、 溶剂黄146 、 硫脲 、 三氟乙酸 作用下， 以 四氢呋喃 、 吡啶 、 甲醇 、 乙醇 、 二氯甲烷 、 水 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 、 甲苯 、 乙腈 、 苯 为溶剂， 反应 34.5h， 生成 [3-O-benzyl-4-O-(4-methoxybenzyl)-α-L-idopyranosyluronic acid]-(1->3)-(2-acetamido-6-O-benzyl-2-deoxy-4-O-pivaloyl-β-D-galactopyranosyl)-(1->4)-methyl 3-O-benzyl-α-L-idopyranosiduronic acid
  参考文献：
  名称：

  An access to various sulfation patterns in dermatan sulfate: chemical syntheses of sulfoforms of trisaccharide methyl glycosides

  摘要：

  The syntheses are reported for the first time of alpha-L-IdopA(2)SO(3)-(1-->3)-beta-D-GalpNAc4SO(3)-(1-->4)-alpha-L-IdopA2SO(3)-(1-->OMe), its disulfated analogue alpha-L-IdopA2SO(3)-(1-->3)-beta-D-GalpNAc4SO(3)-(1-->4)-alpha-L-IdopA2SO(3)-(1-->OMe), and of beta-D-GalpNAc4SO(3)-(1-->4)-alpha-L-IdopA2SO(3)-(1-->3)-beta-D-GalpNAc4SO(3)-(1-->OMe), which represent structural fragments of dermatan sulfate, unavailable directly by chemical or enzymatic degradation of the glycosaminoglycan polymer. These molecules were readily obtained from a pair of key disaccharide intermediates, in which the relative difference of stability of the D-GalNAc 4-hydroxy protecting groups (acetate or pivalate) toward saponification conditions allowed access to various sulfoforms from a common precursor. For the preparation of these blocks, the 4-O-pivaloyl-D-galacto moiety was readily obtained through a one-pot stereospecific intramolecular nucleophilic displacement on an easily available 3-O-pivaloyl-D-gluco precursor,and the L-IdoA moiety through selective radical oxidation at C-6 of a L-ido 4,6-diol derivative with oxoammonium salts. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(02)00060-5