2,5-Dibromthiophenol | 38441-47-3

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物 - 芳香烃
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 英文名称: 2,5-Dibromthiophenol
• 英文别名: 2,5-Dibromobenzenethiol
• CAS: 38441-47-3
• 化学式: C₆H₄Br₂S
• 分子量: 267.972
• InChiKey: ZUAMDMWZDFEYFG-UHFFFAOYSA-N

物化性质

• 熔点：
  39-40 °C
• 沸点：
  287.2±30.0 °C(Predicted)
• 密度：
  1.993±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,5-Dibromthiophenol 在 双氧水 、 potassium carbonate 、 sodium iodide 作用下， 以 溶剂黄146 、 丙酮 为溶剂， 反应 145.0h， 生成 2,5-dibromo-(3,7-dimethyloctylsulfonyl)benzene
  参考文献：
  名称：

  Detert, Heiner; Sugiono, Erli, Advanced Synthesis and Catalysis, 1999, vol. 341, # 4, p. 358 - 362

  摘要：

  DOI：
• 作为产物：
  描述：

  2,5-二溴苯磺酰氯 在 硫酸 、 锌 作用下， 生成 2,5-Dibromthiophenol
  参考文献：
  名称：

  The Condensation of Thiophenols with Secondary Amines and Formaldehyde

  摘要：

  DOI：

  10.1021/ja01644a030

文献信息

• [EN] METHYLAMINE DERIVATIVES AS LYSYSL OXIDASE INHIBITORS FOR THE TREATMENT OF CANCER<br/>[FR] DÉRIVÉS DE LA MÉTHYLAMINE COMME INHIBITEURS DE LA LYSYL OXIDASE POUR LE TRAITEMENT DU CANCER
  申请人：THE INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL

  公开号：WO2017141049A1

  公开（公告）日：2017-08-24

  Provided are compounds of the Formula (I), or a pharmaceutically acceptable salt thereof, wherein W, X, Y, Z, x, R1, R2, R3, x and n are defined in the specification. The compounds are inhibitors of lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family members (LOXL1, LOXL2, LOXL3, LOXL4) and are useful in therapy, particularly in the treatment of cancer. Also disclosed are LOX inhibitors for use in the treatment of a cancer associated with EGFR and biomarkers that predict responsiveness to a LOX inhibitor.

  提供的是Formula (I)的化合物，或其药用可接受的盐，其中W、X、Y、Z、x、R1、R2、R3、x和n在规范中有定义。这些化合物是赖氨酸氧化酶（LOX）和赖氨酸氧化酶样（LOXL）家族成员（LOXL1、LOXL2、LOXL3、LOXL4）的抑制剂，并且在治疗中很有用，特别是在癌症治疗中。还披露了用于治疗与EGFR相关的癌症的LOX抑制剂，以及预测对LOX抑制剂响应性的生物标志物。
• Cardiotonic and antithrombotic sulfur-containing derivatives of
  申请人：Boehringer Ingelheim GmbH

  公开号：US04329347A1

  公开（公告）日：1982-05-11

  Compounds of the formula ##STR1## wherein W is vinylene, methyl-vinylene, methylene or ethylene; m is 0, 1 or 2; D is straight or branched alkylene of 2 to 6 carbon atoms, straight or branched hydroxy-alkylene of 3 to 6 carbon atoms, or xylylene; R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is cycloalkyl of 3 to 6 carbon atoms, aryl of 6 to 10 carbon atoms, aralkyl of 7 to 11 carbon atoms, heteroaryl, heteroarlkyl, 1,2,4-triazolyl, triphenylmethyl, 4,5-bis-(p-chlorophenyl)-oxazol-2-yl, N-methyl-cyclohexylamino-carbonylmethyl,-amino-iminomethyl or, when m is 1 or D is hydroxyalkylene or xylylene, also alkyl of 1 to 6 carbon atoms; and R.sub.3 and R.sub.4 are each hydrogen, halogen, alkyl of 1 to 4 carbon atoms, amino, acetylamino or nitro. The compounds of the invention are useful as cardiotonics and as antithrombotics.

  式为##STR1##的化合物，其中W为乙烯基、甲基乙烯基、亚甲基或乙烯基；m为0、1或2；D为2至6个碳原子的直链或支链烷基、3至6个碳原子的直链或支链羟基烷基，或二甲苯基；R.sub.1为氢或1至3个碳原子的烷基；R.sub.2为3至6个碳原子的环烷基、6至10个碳原子的芳基、7至11个碳原子的芳基烷基、杂环芳基、杂环芳基烷基、1,2,4-三唑基、三苯甲基、4,5-双-(对氯苯基)-噁唑-2-基、N-甲基环己基氨基甲酰甲基、氨基亚甲基或当m为1或D为羟基烷基或二甲苯基时，也为1至6个碳原子的烷基；以及R.sub.3和R.sub.4分别为氢、卤素、1至4个碳原子的烷基、氨基、乙酰氨基或硝基。本发明的化合物可用作心力衰竭药和抗血栓药。
• Process for producing bishalophenyl disulfide
  申请人：——

  公开号：US20030060665A1

  公开（公告）日：2003-03-27

  This invention is directed to a process for producing a bishalophenyl disulfide, chracterized by reacting a halothiophenol with an alkali metal hydroxide to obtain an alkali metal halothiophenolate and subsequently converting the halothiophenolate into a disulfide with an oxidizing agent in the presence of a mineral acid. By the process, a bishalophenyl disulfide having a high purity can be industrially produced in high yield.

  这项发明涉及一种制备双硫代二苯酚的方法，其特点是通过将卤代硫代酚与碱金属氢氧化物反应，得到碱金属卤代硫代苯酚，然后在矿酸存在下，将卤代硫代苯酚转化为二硫化物，通过这种方法，可以在高产率下工业生产高纯度的双硫代二苯酚。
• 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치
  申请人：DUK SAN NEOLUX CO., LTD. 덕산네오룩스 주식회사(120150011099) Corp. No ▼ 161511-0176036BRN ▼312-86-74729

  公开号：KR20180032347A

  公开（公告）日：2018-03-30

  화학식 1로 표시되는 화합물과, 제1전극, 제2전극 및 제1전극과 제2전극 사이의 유기물층을 포함하는 유기전기소자 및 이를 포함하는 전자장치가 개시되며, 유기물층에 화학식 1로 표시되는 화합물을 포함됨으로써, 유기전기소자의 구동전압을 낮출 수 있고, 발광효율 및 수명을 향상시킬 수 있다.

  这是一段专利描述的内容，翻译成中文如下：包括标有化学式1的化合物、第1电极、第2电极以及包含有机物层的有机电子器件和包含该有机物层的电子装置被提出，通过在有机物层中包含标有化学式1的化合物，可以降低有机电子器件的驱动电压，并且可以提高发光效率和寿命。
• GOLF BALL
  申请人：Tarao Toshiyuki

  公开号：US20130053182A1

  公开（公告）日：2013-02-28

  The present invention provides a golf ball comprising a spherical core and at least one cover layer covering the spherical core, wherein the cover is formed from a polyurethane composition containing a polyurethane elastomer as a resin component, the polyurethane composition satisfying properties of rebound resilience of 54% or more and a shear loss modulus G″ of 5.03×10 6 Pa or less when measured in a shear mode using a dynamic viscoelasticity measuring apparatus at the conditions of the temperature of 0° C., and the oscillation frequency of 10 Hz, and the spherical core has a hardness distribution that R 2 of a linear approximate curve determined by a least-squares method is 0.95 or more, when plotting JIS-C hardness measured at a center, a surface and at intervals of 2.5 mm from the center of the spherical core, versus distances from the center of the spherical core.

  本发明提供了一种高尔夫球，包括一个球形的核心和至少一个覆盖在球形核心上的覆盖层，其中覆盖层由聚氨酯弹性体作为树脂组分形成的聚氨酯组合物制成，该聚氨酯组合物在0℃的温度、10 Hz的振荡频率下使用动态粘弹性测量仪以剪切模式测量时，反弹弹性性能为54%或更高，剪切损失模量G″为5.03×106Pa或更低，并且球形核心具有硬度分布，当在球形核心的中心、表面和距离球形核心中心2.5毫米的间隔处测量JIS-C硬度，并将距离从球形核心中心绘制成最小二乘法确定的线性近似曲线的R2为0.95或更高。