4-羟基苯硫醇钠 | 35204-48-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 中文名称: 4-羟基苯硫醇钠
• 英文名称: Sodium;4-sulfanylphenolate
• CAS: 35204-48-9
• 化学式: C₆H₅OS*Na
• 分子量: 148.161
• InChiKey: SDXSUJCQXKCRAH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.95
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  六氯苯 、 4-羟基苯硫醇钠 以 various solvent(s) 为溶剂， 反应 5.0h， 以90%的产率得到hexakis(4-hydroxyphenylthio)benzene
  参考文献：
  名称：

  Subsite-differentiated analogs of biological [4Fe-4S]2+ clusters: synthesis, solution and solid-state structures, and subsite-specific reactions

  摘要：

  DOI：

  10.1021/ja00216a023
• 作为产物：
  描述：

  4-羟基苯硫酚 在 sodium hydride 作用下， 以 乙腈 为溶剂， 反应 0.08h， 生成 4-羟基苯硫醇钠
  参考文献：
  名称：

  [EN] USE OF alpha-PHENYLTHIOCARBOXYLIC AND alpha-PHENYLOXYCARBOXYLIC ACIDS WITH SERUM-GLUCOSE-LOWERING AND SERUM-LIPID-LOWERING ACTIVITY
  [FR] UTILISATION D'ACIDES 20040708WO03059875A2SIGMA TAU IND FARMACEUTI [IT], et al200307241,74-7,14,17,18,20-26PX1-7,10,15PXWINEGAR D A ET AL: "Role of peroxisome proliferator-activated receptors in atherosclerosis", CURRENT OPINION IN CARDIOVASCULAR, PULMONARY AND RENAL INVESTIGATIONAL DRUGS 2000 UNITED KINGDOM, vol. 2, no. 3, 2000, pages 233 - 243, XP008029337, ISSN: 1464-8482WINEGAR D A ET ALRole of peroxisome proliferator-activated receptors in atherosclerosisCURRENT OPINION IN CARDIOVASCULAR, PULMONARY AND RENAL INVESTIGATIONAL DRUGS 2000 UNITED KINGDOM2000231464-8482233243page 236, left-hand column, last paragraph237L1,21X1,2,7,8,10-12,15XBROOKS D A ET AL: "Design and synthesis of 2-methyl-2-{4-[2-(5-methyl-2- aryloxazol-4-yl)ethoxy]phenoxy}propionic acids: a new class of dual PPARalpha/gamma agonists", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 44, no. 13, 21 June 2001 (2001-06-21), pages 2061 - 2064, XP002184099, ISSN: 0022-2623BROOKS D A ET ALDesign and synthesis of 2-methyl-2-{4-[2-(5-methyl-2- aryloxazol-4-yl)ethoxy]phenoxy}propionic acids: a new class of dual PPARalpha/gamma agonistsJOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US2001062144130022-262320612064Chart 112063R1,2X1-3,7,10-12,15XLALEZARI I ET AL: "LR-16 A COMPOUND WITH POTENT EFFECTS ON THE OXYGEN AFFINITY OF HEMOGLOBIN ON BLOOD CHOLESTEROL AND ON LOW DENSITY LIPOPROTEIN", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 85, no. 16, 1988, 1988, pages 6117 - 6121, XP001161155, ISSN: 0027-8424LALEZARI I ET ALLR-16 A COMPOUND WITH POTENT EFFECTS ON THE OXYGEN AFFINITY OF HEMOGLOBIN ON BLOOD CHOLESTEROL AND ON LOW DENSITY LIPOPROTEINPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES1988198885160027-842461176121Scheme 1page 6117, abstractX1,2,10-12,15XUS3262850AMOSS JONES WILLIAM GLYNNE, et al19660726111719X1,2,10-12,15XGB1422679AFUNAI PHARMACEUTICAL IND LTD19760128112126X1,2,7,10-12,15XGRONOWITZ S ET AL: "POTENTIAL HYPOLIPIDEMIC AGENTS XIX. SYNTHESIS AND LIPID-LOWERING PROPERTIES OF THIOPHENE DERIVATIVES RELATED TO CLOFIBRATE", ACTA PHARMACEUTICA SUECICA, XX, XX, vol. 15, no. 5, 1978, pages 361 - 367, XP001053343, ISSN: 0001-6675GRONOWITZ S ET ALPOTENTIAL HYPOLIPIDEMIC AGENTS XIX. SYNTHESIS AND LIPID-LOWERING PROPERTIES OF THIOPHENE DERIVATIVES RELATED TO CLOFIBRATEACTA PHARMACEUTICA SUECICA, XX, XX19781550001-667536136713641X1,3,10-12,15XDURIEZ P ET AL: "POST-STATIN APPROACHES TO HYPERLIPIDAEMIA", EXPERT OPINION ON INVESTIGATIONAL DRUGS, ASHLEY PUBLICATIONS LTD., LONDON, GB, vol. 7, no. 12, December 1998 (1998-12-01), pages 1997 - 2009, XP000892408, ISSN: 1354-3784DURIEZ P ET ALPOST-STATIN APPROACHES TO HYPERLIPIDAEMIAEXPERT OPINION ON INVESTIGATIONAL DRUGS, ASHLEY PUBLICATIONS LTD., LONDON, GB1998127121354-37841997200920023.1Y1-15YBROWN P J ET AL: "A Ureido-Thiobutyric Acid (GW9578) is a subtype-Selective PPARalpha Agonist with Potent lipid-Lowering Activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 19, 9 April 1999 (1999-04-09), pages 3785 - 3788, XP002128791, ISSN: 0022-2623BROWN P J ET ALA Ureido-Thiobutyric Acid (GW9578) is a subtype-Selective PPARalpha Agonist with Potent lipid-Lowering ActivityJOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US1999040942190022-262337853788Chart 1page 3787, left-hand column, last paragraphY1-15YGUERRE-MILLO MICHELE ET AL: "Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 22, 2 June 2000 (2000-06-02), pages 16638 - 16642, XP002275720, ISSN: 0021-9258GUERRE-MILLO MICHELE ET ALPeroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposityJOURNAL OF BIOLOGICAL CHEMISTRY20000602275220021-9258166381664216641R3Y1-15YZHANG BEI B ET AL: "New approaches in the treatment of type 2 diabetes", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 4, no. 4, August 2000 (2000-08-01), pages 461 - 467, XP002275721, ISSN: 1367-5931ZHANG BEI B ET ALNew approaches in the treatment of type 2 diabetesCURRENT OPINION IN CHEMICAL BIOLOGY200008441367-5931461467463L31Y1-15YHAWKE ROY L ET AL: "Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity", JOURNAL OF LIPID RESEARCH, vol. 38, no. 6, 1997, pages 1189 - 1203, XP002275722, ISSN: 0022-2275HAWKE ROY L ET ALPotent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activityJOURNAL OF LIPID RESEARCH19973860022-227511891203entire documentAA

  摘要：

  本文描述了使用具有以下公式（I）的α-苯基硫代羧酸和α-苯基氧羧酸的衍生物进行制备药物，用于预防和治疗糖尿病，特别是2型糖尿病、其并发症、各种形式的胰岛素抵抗和高脂血症。其中，取代基的含义在文本中有描述。

  公开号：

  WO2004056355A1

文献信息

• Compositions for repelling crawling insects
  申请人：——

  公开号：US20020094993A1

  公开（公告）日：2002-07-18

  The present invention relates to novel compositions, comprising a repellent and an additive, where the additive is selected from the group consisting of phenol, benzaldehyde, benzoic acid or derivatives thereof and is present in a ratio of from 10:100 to 200:100% by weight to the repellent, and to their use for repelling crawling harmful insects, in particular ants or cockroaches.

  本发明涉及新型组合物，包括一种驱虫剂和一种添加剂，其中所述添加剂选自苯酚、苯甲醛、苯甲酸或其衍生物组成的群体，并以10:100至200:100％重量的比例存在于驱虫剂中，以及其用于驱赶爬行有害昆虫，特别是蚂蚁或蟑螂。
• Partially cyclized polyacrylonitrile polymer, polyacrylonitrile flame-resistant polymer, polyacrylonitrile flame-resistant fiber, carbon fiber, and preparation methods thereof
  申请人：Mitsubishi Chemical Corporation

  公开号：US10087075B2

  公开（公告）日：2018-10-02

  A high-quality flame-resistant fiber and carbon fiber at low costs in preparing a flame-resistant fiber and a carbon fiber by efficiently performing a flame retardation process in a short time as compared with a conventional technology are described. [1] If a polyacrylonitrile (PAN) polymer is degenerated with an oxidizing agent containing a thiolate compound and a nitrogen atom in a polymer, and the degenerated polymer is formed into threads so as to prepare a flame-resistant PAN fiber. [2] A flame-resistant PAN fiber is prepared by degenerating a PAN precursor fiber in a solution including a thiolate compound and an oxidizing agent containing a nitrogen atom. The flame-resistant PAN fiber obtained by the preparation method is heated at 300° C. or more to 3000° C. or less, and, thus, a carbon fiber having an excellent mechanical strength can be obtained.

  与传统技术相比，本发明通过在短时间内高效地进行阻燃处理，以较低的成本制备出高质量的阻燃纤维和碳纤维。[1] 如果在聚合物中使用含有硫代化合物和氮原子的氧化剂使聚丙烯腈（PAN）聚合物变性，并将变性聚合物制成丝状，从而制备阻燃 PAN 纤维。[2] 阻燃 PAN 纤维的制备方法是将 PAN 原丝在含有硫代化合物和氮原子的氧化剂的溶液中变性。将通过该制备方法获得的阻燃 PAN 纤维在 300° C 或更高温度下加热至 3000° C 或更低温度，可获得机械强度极佳的碳纤维。
• Kniess, Torsten; Mayer, Roland, Phosphorus, Sulfur and Silicon and the Related Elements, 1994, vol. 97, # 1-4, p. 223 - 231
  作者：Kniess, Torsten、Mayer, Roland

  DOI：——

  日期：——
• PARTIALLY CYCLIZED POLYACRYLONITRILE POLYMER, POLYACRYLONITRILE FLAME-RESISTANT POLYMER, POLYACRYLONITRILE FLAME-RESISTANT FIBER, CARBON FIBER, AND PREPARATION METHODS THEREOF
  申请人：MITSUBISHI RAYON CO., LTD.

  公开号：US20160376151A1

  公开（公告）日：2016-12-29

  A high-quality flame-resistant fiber and carbon fiber at low costs in preparing a flame-resistant fiber and a carbon fiber by efficiently performing a flame retardation process in a short time as compared with a conventional technology are described. [1] If a polyacrylonitrile (PAN) polymer is degenerated with an oxidizing agent containing a thiolate compound and a nitrogen atom in a polymer, and the degenerated polymer is formed into threads so as to prepare a flame-resistant PAN fiber. [2] A flame-resistant PAN fiber is prepared by degenerating a PAN precursor fiber in a solution including a thiolate compound and an oxidizing agent containing a nitrogen atom. The flame-resistant PAN fiber obtained by the preparation method is heated at 300° C. or more to 3000° C. or less, and, thus, a carbon fiber having an excellent mechanical strength can be obtained.
• US5268482A
  申请人：——

  公开号：US5268482A

  公开（公告）日：1993-12-07